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532 条记录 (耗时 0.057 秒)

    IDENTIFYING VIRAL CELL TROPISM
    52.
    发明申请
    IDENTIFYING VIRAL CELL TROPISM 有权
    鉴定病毒细胞

    公开(公告)号：US20130040832A1

    公开(公告)日：2013-02-14

    申请号：US13394002

    申请日：2010-09-01

    申请人： Charles-Henri Lecellier ,  Valerie Courgnaud ,  Manuella Bouttier ,  Diane Descamps ,  Gilles Collin

    发明人： Charles-Henri Lecellier ,  Valerie Courgnaud ,  Manuella Bouttier ,  Diane Descamps ,  Gilles Collin

    IPC分类号： C12Q1/70 ,  C40B30/04

    CPC分类号： C12Q1/6813

    摘要： The invention relates to an in vitro method for identifying microRNAs or the target mRNAs thereof, the expression of which during the infection of cells by a virus using a cell receptor and at least one cell co-receptor for entering the cell, is specifically modified on the basis of the cell co-receptor used by the virus for its entering the cells, comprising: i) determining the microRNA expression levels in a test cell expressing a receptor, a first co-receptor and at least one other co-receptor, after infection by a first virus using the first co-receptor and by at least one other virus using another co-receptor, respectively; ii) identifying the microRNAs, the expression level of which is modulated during the infection by each of the viruses in relation to the expression level in the uninfected cells; iii) comparing the thus-identified microRNAs; iv) selecting the microRNAs, the modification of the expression level of which is specific to the use of a co-receptor; v) optionally identifying the target mRNAs of the thus-selected microRNAs.

    摘要翻译： 本发明涉及用于鉴定微小RNA或其靶mRNA的体外方法，其在使用细胞受体和至少一种用于进入细胞的细胞共同受体的病毒感染细胞期间的表达被特异性修饰 由病毒用于进入细胞的细胞共受体的基础，包括：i）在表达受体，第一共受体和至少一种其它共 - 受体的测试细胞中测定microRNA表达水平，之后 使用第一共受体的第一病毒的感染和使用另一种辅助受体的至少一种其它病毒感染; ii）识别在每个病毒感染期间相对于未感染细胞中的表达水平调节其表达水平的微小RNA; iii）比较如此鉴定的微小RNA; iv）选择微小RNA，其表达水平的修饰对共受体的使用是特异性的; v）任选地鉴定如此选择的微小RNA的靶mRNA。

    Endoprosthesis, and method for producing an endoprosthesis
    55.
    发明授权
    Endoprosthesis, and method for producing an endoprosthesis 有权
    内假体，以及内置假体的制造方法

    公开(公告)号：US08187317B2

    公开(公告)日：2012-05-29

    申请号：US12439724

    申请日：2007-09-04

    申请人： Pascal Leprince ,  Mourad Karouia ,  Johan Mazeyrat ,  Olivier Romain ,  Pierre-Yves Lagree ,  Patrick Garda ,  Hamid Kokabi

    发明人： Pascal Leprince ,  Mourad Karouia ,  Johan Mazeyrat ,  Olivier Romain ,  Pierre-Yves Lagree ,  Patrick Garda ,  Hamid Kokabi

    IPC分类号： A61F2/06

    CPC分类号： A61B5/076 ,  A61B5/0215 ,  A61B5/6862 ,  A61B5/6876 ,  A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2250/0002

    摘要： The endoprosthesis is designed to be implanted in an aneurysm (12) of a patient, the aneurysm (12) resulting from deformation of a vessel wall, in particular the wall of an artery (14), the endoprosthesis including: a tubular envelope (22, 24) that extends in a direction (Y-Y′), and a plurality of pressure probes (26) fixed on the envelope (22, 24), each probe (26) including: a sensor (28) for measuring pressure, and elements (34, 36) for transmitting the pressure measurement to a monitoring apparatus located outside the patient. The elements (34, 36) for transmitting the pressure measurement from each probe (26) are designed to generate an electromagnetic pressure measurement transmission signal including at least one distinctive characteristic of the probe (26) of which these elements (34, 36) form part.

    摘要翻译： 内置假体被设计成植入患者的动脉瘤（12），动脉瘤（12）由血管壁变形，特别是动脉壁（14）引起，内假体包括：管状外壳（22） ，24），以及固定在所述外壳（22,24）上的多个压力探针（26），每个探针（26）包括：用于测量压力的传感器（28）和元件 （34,36），用于将压力测量传送到位于患者外部的监视装置。 用于从每个探针（26）传送压力测量的元件（34,36）被设计成产生电磁测压传输信号，其包括探头（26）的至少一个不同特征，这些元件（34,36）形成 部分。

    DUAL MOLECULES CONTAINING A PEROXIDE DERIVATIVE, THEIR SYNTHESIS AND THERAPEUTIC USES
    56.
    发明申请
    DUAL MOLECULES CONTAINING A PEROXIDE DERIVATIVE, THEIR SYNTHESIS AND THERAPEUTIC USES 审中-公开
    含有过氧化物衍生物的双分子，其合成和治疗用途

    公开(公告)号：US20120122923A1

    公开(公告)日：2012-05-17

    申请号：US12332633

    申请日：2008-12-11

    申请人： Frederic COSLEDAN ,  Bernard MEUNIER ,  Alain PELLET

    发明人： Frederic COSLEDAN ,  Bernard MEUNIER ,  Alain PELLET

    IPC分类号： A61K31/47 ,  A61P33/06 ,  C07D405/12

    CPC分类号： C07D405/12

    摘要： The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R5 represents a hydrogen atom, an alkyl, cycloalkyl or C1-3-alkylene-cycloakyl group; Z1 and Z2 represent an alkyl radical, the group Z1+Z2+Ci+Cj representing a mono- or polycyclic structure, with one of the Z1 or Z2 being able to represent a single bond; R1 and R2, identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; Rx and Ry forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R3 groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diasteroisomers and their mixtures. Preparation method and use as medications with antimalarial activity.

    摘要翻译： 本发明涉及对应于式（I）的双分子：其中：A表示具有式（IIa）或（IIIa）的抗疟活性的分子残基或促进生物利用度的残基; B表示可被取代的环烷基，或B表示可被取代的双环或三环基，或B表示通过单键或亚烷基链连接在一起的2个环烷基; m和n彼此独立地表示0,1或2; R5表示氢原子，烷基，环烷基或C1-3亚烷基 - 环烷基; Z 1和Z 2表示烷基，基团Z 1 + Z 2 + C 1 + C 1表示单环或多环结构，其中Z1或Z2之一能够表示单键; R1和R2相同或不同，表示氢原子或能够提高水溶性的官能团; Rx和Ry一起形成环状过氧化物，其包含4至8个连接并且在环状结构中包含1或2个另外的氧原子，可能被一个或多个R 3基团取代; 除了它们的非对映异构体及其混合物之外，还可以以外消旋体，异构体和它们的混合物作为水合物或溶剂合物加入到酸中的碱或盐。 制备方法和用作具有抗疟活性的药物。

    DIGITAL CONTROL DEVICE FOR A PARALLEL PMOS TRANSISTOR BOARD
    59.
    发明申请
    DIGITAL CONTROL DEVICE FOR A PARALLEL PMOS TRANSISTOR BOARD 有权
    用于并联PMOS晶体管板的数字控制器件

    公开(公告)号：US20110295441A1

    公开(公告)日：2011-12-01

    申请号：US13141466

    申请日：2009-12-17

    申请人： Carlos Canudas De Wit ,  Carolina Albea Sanchez

    发明人： Carlos Canudas De Wit ,  Carolina Albea Sanchez

    IPC分类号： G05D9/12

    CPC分类号： H03K19/0016 ,  H03K17/122

    摘要： A digital control device for a parallel PMOS transistor board, includes: an operative memory for digitally storing error data between a target voltage and a setpoint voltage as well as control data, each datum being provided with a time marker, a digital selected order filter (36) for computing setpoint incrementation data from error data in the operative memory selected based on input error data, and for storing the input error data with a corresponding time marker in the operative memory, and a control computer (38) for computing new control data from the control incrementation data and control data in the operative memory selected based on input error data and for storing the new control data in the operative memory.

    摘要翻译： 一种用于并联PMOS晶体管板的数字控制装置，包括：用于数字地存储目标电压和设定点电压之间的误差数据的操作存储器以及控制数据，每个数据被提供有时间标记，数字选择顺序滤波器 36），用于从基于输入错误数据选择的操作存储器中的错误数据计算设定值增量数据，以及用于将输入错误数据与对应的时间标记存储在操作存储器中;以及控制计算机（38），用于计算新的控制数据 来自基于输入错误数据选择的操作存储器中的控制增量数据和控制数据，以及用于将新的控制数据存储在操作存储器中。

    Method for powering a magnetic coupler and device for powering an electric dipole
    60.
    发明授权
    Method for powering a magnetic coupler and device for powering an electric dipole 有权
    为电耦合器供电的方法和用于为偶极子供电的装置

    公开(公告)号：US08009003B2

    公开(公告)日：2011-08-30

    申请号：US12446035

    申请日：2007-10-22

    申请人： Eric Laboure ,  Thierry Antoine Meynard ,  François Forest

    发明人： Eric Laboure ,  Thierry Antoine Meynard ,  François Forest

    IPC分类号： H01F30/12

    CPC分类号： H01F30/12 ,  H01F30/14 ,  H01F2038/006

    摘要： A method for powering a magnetic coupler, in which: a) each winding of a first magnetic elementary cell is powered such as to produce a magnetizing flux in a bar of the first cell which is joined with a second cell, the fundamental component of which has an angular offset xi; and b) powering each winding of the second cell such as to produce a magnetizing flux in the bar of the second cell which is joined with the first cell, the fundamental component of which has an angular offset xj. The absolute value of the difference between the angular offsets xi and xj is greater than or equal to (I) rad.

    摘要翻译： 一种用于为磁耦合器供电的方法，其中：a）第一磁性单元的每个绕组被供电，以便在第一单元的条中产生磁化通量，所述磁化通量与第二单元连接，第二单元的基本分量 具有角度偏移xi; 以及b）为所述第二单元的每个绕组供电，以便在所述第二单元的所述条中产生磁化通量，所述磁化通量与所述第一单元连接，所述第一单元的基本分量具有角度偏移xj。 角度偏移xi和xj之间的差的绝对值大于或等于（I）rad。