公开(公告)号：US06464625B2

公开(公告)日：2002-10-15

申请号：US09338687

申请日：1999-06-23

Applicant: Robert A. Ganz

Inventor： Robert A. Ganz

IPC: A61N500

CPC classification number: A61N5/0601 ,  A61B18/24 ,  A61B2017/22051 ,  A61B2018/00982 ,  A61B2018/2261 ,  A61N5/1001 ,  A61N2005/0609 ,  A61N2005/0651 ,  A61N2005/0654 ,  A61N2005/0661 ,  H01J35/32 ,  H01J2235/164

Abstract: A treatment method and apparatus for debilitating or killing Helicobacter pylori or other microorganisms within the body of a patient is especially suited for treating stomach or duodenal ulcers. The present therapeutic method involves the use of ionizing radiation for eliminating pathogenic microorganisms within or supported upon the lining of a body cavity of a patient, e.g., the stomach. An elongated flexible shaft is provided for insertion into the body in any of various ways selected by the surgeon. It can be placed endoscopically, e.g., through the esophagus, placed surgically, placed laparoscopically or by CAT scan-guided percutaneous insertion. A radiant energy distribution head is provided at the end of the flexible shaft to transmit ionizing radiation for destroying microorganisms within the body. Radiant energy, e.g., x-ray, ultraviolet light, beta radiation, gamma radiation, radio waves, microwaves, or infrared energy, is then transferred from the head of the instrument to the epithelium around the head of the instrument in an amount sufficient to debilitate or kill the Helicobacter pylori or other microorganisms in the lining of the body cavity.

Abstract translation: 幽门螺杆菌或患者体内幽门螺杆菌或其他微生物衰弱或杀伤的治疗方法和装置特别适用于治疗胃或十二指肠溃疡。 本治疗方法包括使用电离辐射来消除病人微生物内部或支撑在患者体腔（例如胃）的衬里内。 提供细长的柔性轴以用外科医生选择的各种方式插入体内。 它可以内窥镜放置，例如通过食道放置，手术放置，腹腔镜放置或通过CAT扫描引导经皮插入。 辐射能量分布头设置在柔性轴的端部以传输用于破坏身体内的微生物的电离辐射。 然后将辐射能量，例如x射线，紫外线，β辐射，γ辐射，无线电波，微波或红外能量从仪器的头部转移到仪器头部周围的上皮，其量足以 使幽门螺杆菌或身体内衬中的其他微生物衰弱或死亡。

公开(公告)号：US20020054664A1

公开(公告)日：2002-05-09

申请号：US09792072

申请日：2001-02-26

Inventor： Jonas Tiren

IPC: H01J035/00

CPC classification number: A61N5/1001 ,  H01J35/32 ,  H01J2201/304 ,  H01J2235/164

Abstract: Miniature X-ray source comprising a support structure provided with a through-going hole, an anode is arranged at one end and a cathode (8,24) at the other end of the hole, thereby defining a cavity, the anode and cathode are adapted to be energised in order to generate X-ray radiation. The support structure has a cross-sectional shape that is determined such that a desired radiation distribution of the radiation generated by the X-ray source is achieved. Also a method of manufacturing miniature X-ray sources is disclosed.

Abstract translation: 包括具有通孔的支撑结构的微型X射线源，一端设置阳极，在该孔的另一端设有阴极（8,24），从而形成空腔，阳极和阴极 适于通电以产生X射线辐射。 支撑结构具有被确定为使得由X射线源产生的辐射的期望的辐射分布被实现的横截面形状。 还公开了一种制造微型X射线源的方法。

公开(公告)号：US20010049464A1

公开(公告)日：2001-12-06

申请号：US09338687

申请日：1999-06-23

Inventor： ROBERT A. GANZ

IPC: A61N005/00

CPC classification number: A61N5/0601 ,  A61B18/24 ,  A61B2017/22051 ,  A61B2018/00982 ,  A61B2018/2261 ,  A61N5/1001 ,  A61N2005/0609 ,  A61N2005/0651 ,  A61N2005/0654 ,  A61N2005/0661 ,  H01J35/32 ,  H01J2235/164

Abstract: A treatment method and apparatus for debilitating or killing Helicobacter pylori or other microorganisms within the body of a patient is especially suited for treating stomach or duodenal ulcers. The present therapeutic method involves the use of ionizing radiation for eliminating pathogenic microorganisms within or supported upon the lining of a body cavity of a patient, e.g., the stomach. An elongated flexible shaft is provided for insertion into the body in any of various ways selected by the surgeon. It can be placed endoscopically, e.g., through the esophagus, placed surgically, placed laparoscopically or by CAT scan-guided percutaneous insertion. A radiant energy distribution head is provided at the end of the flexible shaft to transmit ionizing radiation for destroying microorganisms within the body. Radiant energy, e.g., x-ray, ultraviolet light, beta radiation, gamma radiation, radio waves, microwaves, or infrared energy, is then transferred from the head of the instrument to the epithelium around the head of the instrument in an amount sufficient to debilitate or kill the Helicobacter pylori or other microorganisms in the lining of the body cavity.

Abstract translation: 幽门螺杆菌或患者体内幽门螺杆菌或其他微生物衰弱或杀伤的治疗方法和装置特别适用于治疗胃或十二指肠溃疡。 本治疗方法包括使用电离辐射来消除病人微生物内部或支撑在患者体腔（例如胃）的衬里内。 提供细长的柔性轴以用外科医生选择的各种方式插入体内。 可以内窥镜放置，例如通过食道放置，手术放置，腹腔镜放置或通过CAT扫描引导经皮插入。 辐射能量分布头设置在柔性轴的端部以传输用于破坏身体内的微生物的电离辐射。 然后将辐射能量，例如x射线，紫外线，β辐射，γ辐射，无线电波，微波或红外能量从仪器的头部转移到仪器头部周围的上皮，其量足以 使幽门螺杆菌或身体内衬中的其他微生物衰弱或死亡。

公开(公告)号：US06195411B1

公开(公告)日：2001-02-27

申请号：US09311792

申请日：1999-05-13

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: H01J3506

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/087 ,  H01J2235/164

Abstract: This invention is directed to a radiation source comprising a power supply, a flexible fiber optic cable assembly, a light source, and a target assembly. The power supply includes a first terminal and a second terminal, and elements for establishing an output voltage between the first terminal and the second terminal. The flexible fiber optical cable assembly has an originating end and a terminating end, and includes a fiber optical element extending from the originating end to the terminating end. The cable is adapted for transmitting light incident on the originating end to the terminating end. The light source includes elements for generating a beam of light at and directed to the originating end of the fiber optical cable assembly. The target assembly is affixed to the terminating end of the fiber optical cable assembly and is electrically coupled to the power supply by way of the first terminal and the second terminal. The target assembly includes elements for emitting radiation in a predetermined spectral range, in response to light transmitted to the terminating end.

Abstract translation: 本发明涉及一种包括电源，柔性光缆组件，光源和目标组件的辐射源。 电源包括第一端子和第二端子，以及用于在第一端子和第二端子之间建立输出电压的元件。 柔性光纤光缆组件具有起始端和终止端，并且包括从起始端延伸到终端的光纤元件。 电缆适用于将入射在起始端的光线发射到终端。 光源包括用于在光纤光缆组件的起始端处产生光束并被引导到光纤光缆组件的始端的元件。 目标组件固定到光纤光缆组件的终端，并通过第一终端和第二终端电耦合到电源。 目标组件包括响应于传输到终端的光而在预定光谱范围内发射辐射的元件。