公开(公告)号：US20140155296A1

公开(公告)日：2014-06-05

申请号：US14040757

申请日：2013-09-30

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Hasan Khatib ,  Wen Huang

IPC分类号： C12Q1/68 ,  A61D19/02

CPC分类号： C12Q1/6888 ,  A61D19/02 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： A single nucleotide polymorphic site at position 10793 of the bovine POU1F1 gene is associated with improved longevity and milk product traits. Disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods.

摘要翻译： 牛POU1F1基因位置10793处的单核苷酸多态性位点与改善的寿命和乳制品性状相关。 公开了核酸分子，试剂盒，基因分型方法和标记辅助的牛育种方法。

公开(公告)号：US20130267771A1

公开(公告)日：2013-10-10

申请号：US13990987

申请日：2011-12-01

申请人： Kyoko Uchiyama ,  Yoshiaki Minato

发明人： Kyoko Uchiyama ,  Yoshiaki Minato

IPC分类号： A61D19/02

CPC分类号： A61D19/024

摘要： [Problem] To improve the conception chance of semen after cryopreservation by improving conventional straws for artificial insemination. [Solution] A straw for cryopreservation is produced by introducing a partitioning layer into a straw for artificial insemination to separate layers, thereby forming a semen storage layer comprising an aqueous solution containing semen and an anti-freeze agent on one side and a dilution layer containing no anti-freeze agent on the other side, wherein a dilution solution comprising an aqueous solution containing tris(hydroxymethyl aminomethane), citric acid, glucose and sodium chloride is used in the dilution layer.

摘要翻译： [问题]通过改进常规吸管人工授精，提高冷冻保存后精液的概念机会。 [解决方案]通过将分隔层引入用于人工授精以分离层的秸秆来制备用于冷冻保存的秸秆，从而形成包含含有精液和防冻剂在一侧的水溶液的精液储存层和含有 在另一侧没有防冻剂，其中在稀释层中使用包含含有三（羟甲基氨基甲烷），柠檬酸，葡萄糖和氯化钠的水溶液的稀释溶液。

公开(公告)号：US08202210B2

公开(公告)日：2012-06-19

申请号：US11829240

申请日：2007-07-27

申请人： Brad K. Stroud

发明人： Brad K. Stroud

IPC分类号： A61D19/02 ,  A61D7/00

CPC分类号： A61D19/027 ,  A61M31/00

摘要： In the preferred embodiment, bovine semen is mixed with a suitable solution to form an insemination medium which is injected into the reproductive organs of a female bovine to flood the uterine horns in a nonsurgical AI procedure. The invention includes an AI instrument having a disposable, single use pipette that may be used with this nonsurgical procedure. The AI instrument does not include a balloon and is referred to as “catheter free”. Preferably, the uterine horns are flooded concurrently, but in the alternative, they may be flooded sequentially.

摘要翻译： 在优选的实施方案中，将牛精液与合适的溶液混合以形成授精培养基，其被注入雌性牛的生殖器官中以在非手术AI程序中灌注子宫角。 本发明包括具有一次性一次性移液管的AI仪器，其可以与该非手术过程一起使用。 AI仪器不包括气球，被称为“无导尿管”。 优选地，子宫角同时淹没，但是在替代方案中，它们可以顺序淹没。

公开(公告)号：US20120046519A1

公开(公告)日：2012-02-23

申请号：US13265307

申请日：2010-04-23

申请人： Stephen Kent Webel ,  Mark E. Swanson

发明人： Stephen Kent Webel ,  Mark E. Swanson

IPC分类号： A61D19/02 ,  A61K38/08

CPC分类号： A61K38/09 ,  A61D7/00 ,  A61D19/00 ,  A61D19/02 ,  A61K9/0034 ,  A61K9/06 ,  A61K38/24 ,  A61K47/14 ,  A61K47/38

摘要： Methods and compositions for synchronizing the time of insemination in swine are described. More particularly, methods are described for synchronizing the time of insemination by administration of a composition comprising a hormone, wherein the swine is inseminated only one time after administration of the hormone, and wherein there is no heat detection.

摘要翻译： 描述了用于同步猪授精时间的方法和组合物。 更具体地，描述了通过施用包含激素的组合物来同步授精时间的方法，其中在给予激素后仅一次授精猪，并且其中没有热检测。

公开(公告)号：US20110078803A1

公开(公告)日：2011-03-31

申请号：US12806945

申请日：2010-08-24

申请人： John L. Schenk ,  George E. Seidel ,  Tae Kwang Suh

发明人： John L. Schenk ,  George E. Seidel ,  Tae Kwang Suh

IPC分类号： A61D19/02 ,  A01K67/027

CPC分类号： C12N5/0612 ,  A01K67/027 ,  A01K2227/10 ,  A01K2227/101 ,  A61D19/00 ,  C12N5/061 ,  C12N2517/10 ,  Y10T442/2115

摘要： A sex selected equine embryo production system for the production of sex selected equine embryos and offspring by fertilization of oocytes with sex selected sperm by intracytoplasmic sperm injection.

摘要翻译： 通过细胞质内精子注射，通过受性别选择的精子的卵母细胞受精，选择马选择马胚胎生产系统来生产性别选择的马胚胎和后代。

公开(公告)号：US20100305396A1

公开(公告)日：2010-12-02

申请号：US12628012

申请日：2009-11-30

申请人： MARK E. ANDERSON ,  Donald E. Anderson ,  Dolores Rita Anderson

发明人： MARK E. ANDERSON ,  Donald E. Anderson ,  Dolores Rita Anderson

IPC分类号： A61D19/02 ,  A61D1/00

CPC分类号： A61D19/027

摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.

摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。

公开(公告)号：US20100087702A1

公开(公告)日：2010-04-08

申请号：US12286887

申请日：2008-10-03

申请人： Timothy James Williams

发明人： Timothy James Williams

IPC分类号： A61D19/02 ,  A01N1/02 ,  A61D19/00

CPC分类号： A01N1/0226

摘要： A composition and method is provided to modify sperm fertility and sex ratio of mammalian offspring. The composition includes an amount of a class of compounds of phenoxazine or phenothiazine, having the structure (see FIG. 1) and ionic derivatives thereof, wherein R1 is H, a lower alkyl group or N(R3)2, R2 is N, S, O, and R3 is H or a lower alkyl group. A second component of the composition is an amount of an electron transfer agent capable of oxidizing a reduced cofactor (NADPH or NADH). A third component of the composition is an amount of a hexose sugar and/or the phosphorylated esters of such. When mixed with living sperm prior to or at the time of insemination, the composition results in modified rates of conception and an alteration of birth sex ratio in mammal species.

摘要翻译： 提供了一种组合物和方法来改变哺乳动物后代的精子生殖力和性别比例。 该组合物包含一定量的具有结构（参见图1）和其离子衍生物的吩恶嗪或吩噻嗪化合物，其中R 1是H，低级烷基或N（R 3）2，R 2是N，S ，O和R 3为H或低级烷基。 组合物的第二组分是能够氧化还原的辅因子（NADPH或NADH）的电子转移剂的量。 组合物的第三组分是己糖和/或其磷酸化酯的量。 在授精之前或在授精时与生精子混合时，组合物会导致哺乳动物物种的修养率和出生性别比例的变化。

公开(公告)号：US20090281371A1

公开(公告)日：2009-11-12

申请号：US12506723

申请日：2009-07-21

申请人： Brad K. Stroud

发明人： Brad K. Stroud

IPC分类号： A61D19/02

CPC分类号： A61D19/027 ,  A61M25/00 ,  A61M31/00

摘要： In the preferred embodiment, bovine semen is mixed with a “suitable solution” to form an insemination medium which is injected into the reproductive organs of a female bovine to flood the uterine horns in a nonsurgical AI procedure. The invention includes an AI instrument having a disposable, single use pipette that may be used with this nonsurgical procedure. The AI instrument does not include a balloon and is referred to as “catheter free”. Preferably, the uterine horns are flooded concurrently, but in the alternative, they may be flooded sequentially.

摘要翻译： 在优选的实施方案中，将牛精液与“合适的溶液”混合以形成授精培养基，其被注入雌性牛的生殖器官中以在非手术AI程序中灌注子宫角。 本发明包括具有一次性一次性移液管的AI仪器，其可以与该非手术过程一起使用。 AI仪器不包括气球，被称为“无导尿管”。 优选地，子宫角同时淹没，但是在替代方案中，它们可以顺序淹没。

公开(公告)号：US06860235B2

公开(公告)日：2005-03-01

申请号：US10693661

申请日：2003-10-24

申请人： Donald E. Anderson ,  Mark E. Anderson ,  Glenn M. Anderson ,  Kang S. Lim

发明人： Donald E. Anderson ,  Mark E. Anderson ,  Glenn M. Anderson ,  Kang S. Lim

IPC分类号： A61D19/02 ,  A01K29/00 ,  A61B17/43

CPC分类号： A61D19/027

摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. Deployment of the membrane is facilitated by tapering its wall thickness towards its tip. In addition to AI and embryo transplant, other applications for the pathway include therapeutic, diagnostic, or other procedures such as introducing fluoroscopic cameras, instruments, and drug delivery.

摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 通过使其壁厚朝其尖端逐渐变细来促进膜的部署。 除了AI和胚胎移植之外，该途径的其他应用包括治疗，诊断或其他手术，例如引入荧光镜照相机，仪器和药物递送。

公开(公告)号：US6090088A

公开(公告)日：2000-07-18

申请号：US243567

申请日：1999-02-03

申请人： Lew O. Nichols

发明人： Lew O. Nichols

IPC分类号： A61D19/02 ,  A61F5/44

CPC分类号： A61D19/021

摘要： A phantom mare includes a housing having inlet and outlet ends with a bore therebetween. A bladder surrounds the bore. Upon injection of a warmed fluid into the housing, the fluid is captured between the bladder and bore surface to distend and warm the bladder. Upon stallion penetration in the outlet end the discharged semen is directed to a collection container at the outlet end. A valve assembly regulates a user discharge of the fluid from the housing so that the distended bladder returns to a non-distended position to preclude irritation on the stallion upon withdrawal. The removal of heat of the discharged fluid from the housing reduces the possibility of damage to the deposited semen.

摘要翻译： 幻影母马包括具有入口端和出口端之间具有孔的壳体。 膀胱围绕孔。 在将温热的流体注入到壳体中之后，流体被捕获在囊和孔表面之间，以膨胀和温暖膀胱。 在出口端的种马穿透时，排出的精液在出口端被引导到收集容器。 阀门组件调节使用者从壳体排出流体，使得膨胀的气囊返回到不扩张的位置，以防止在撤出时对种马产生刺激。 将排出的流体从壳体中除去的热量降低了沉积的精液损伤的可能性。