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1.发明授权Methods of detecting oxidized calcium/calmodulin dependent protein kinase II 有权检测氧化钙/钙调蛋白依赖性蛋白激酶II的方法公开(公告)号：US09090701B2
公开(公告)日：2015-07-28
申请号：US13605341
申请日：2012-09-06
IPC分类号： C07K16/40 , C07K16/44 , G01N33/573 , A61P25/28 , G01N33/574
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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公开(公告)号：US08425576B2
公开(公告)日：2013-04-23
申请号：US13013669
申请日：2011-01-25
申请人： Mark E. Anderson , Janette L. Munoz
发明人： Mark E. Anderson , Paul A. Munoz
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/8052
摘要： A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.
摘要翻译： 提供骨稳定系统，其具有具有顶表面和底表面的平板和沿着纵向轴线延伸穿过的孔。 顶表面中的环形槽围绕轴线并且限定与板成一体的多个弹簧构件的面向外侧。 多个槽限定弹簧构件的侧面，弹簧构件的向内侧形成孔的上部，其包括第一球形部分。 在紧固件头部上具有球形部分的紧固件延伸到孔中，弹簧构件被推开以允许头部通过，但是限制去除，直到克服了由弹簧构件提供的阻力。
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3.发明申请Kits for Detecting Direct Oxidation of Calcium/Calmodulin Dependent Protein Kinase II and Associated Diagnostic and Therapeutic Methods 有权用于检测钙/钙调蛋白依赖性蛋白激酶II的直接氧化的试剂盒及相关诊断和治疗方法公开(公告)号：US20130012568A1
公开(公告)日：2013-01-10
申请号：US13605341
申请日：2012-09-06
IPC分类号： G01N33/573 , A61P35/00 , A61P25/28 , A61K31/7088 , A61P9/00
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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公开(公告)号：US20110251451A1
公开(公告)日：2011-10-13
申请号：US13165057
申请日：2011-06-21
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US07971553B2
公开(公告)日：2011-07-05
申请号：US12628012
申请日：2009-11-30
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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6.发明申请EARTH BORING TOOLS AND COMPONENTS THEREOF INCLUDING BLOCKAGE RESISTANT INTERNAL FLUID PASSAGEWAYS, AND METHODS OF FORMING SUCH TOOLS AND COMPONENTS 有权地面钻孔工具及其组件，其中包括阻塞内部流体通道，以及形成这些工具和组件的方法公开(公告)号：US20110073377A1
公开(公告)日：2011-03-31
申请号：US12570852
申请日：2009-09-30
CPC分类号： E21B10/602 , B22D19/14 , C22C1/1036 , C22C9/00
摘要： Earth-boring drill bits include a bit body including a blockage-resistant internal fluid passageway. The blockage-resistant internal fluid passageway includes at least one internal fluid passageway formed in the bit body and a cuttings filtering feature formed in the at least one internal fluid passageway configured to prevent at least some cuttings from flowing through the at least one internal fluid passageway. In one embodiment, the cuttings filtering feature includes at least one lateral member extending transversely across the at least one internal fluid passageway. In another embodiment, the cuttings filtering feature includes forming a central portion of the at least one internal fluid passageway with a width along a lateral axis thereof less than an average width of a fluid path extending through a nozzle disposed at least partially within the at least one internal fluid passageway. Methods of forming the blockage-resistant internal fluid passageway are also disclosed.
摘要翻译： 钻孔钻头包括具有阻塞内部流体通道的钻头体。 防堵塞的内部流体通道包括形成在钻头体中的至少一个内部流体通道和形成在至少一个内部流体通道中的切屑过滤特征，该内部流体通道构造成防止至少一些切屑流过至少一个内部流体通道 。 在一个实施例中，切屑过滤特征包括横向穿过至少一个内部流体通道延伸的至少一个横向构件。 在另一个实施例中，切屑过滤特征包括形成至少一个内部流体通道的中心部分，其宽度沿着其横向轴线小于延伸穿过喷嘴的平均宽度，喷嘴至少部分地至少设置在至少 一个内部流体通道。 还公开了形成耐阻塞内部流体通道的方法。
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公开(公告)号：US20110006182A1
公开(公告)日：2011-01-13
申请号：US12825663
申请日：2010-06-29
IPC分类号： F16M13/02
CPC分类号： G01D4/004 , H01Q1/00 , H01Q1/2233 , H01Q9/00 , Y02B90/242 , Y04S20/322
摘要： A meter pit lid plug and bracket assembly configured to suspend a transmitter plug inside a meter pit is provide. The meter pit lid plug and bracket assembly includes a plug and a bracket. The plug includes a head and a stem that extends from the head. The stem is also configured to extend through a hole in a meter pit having a top surface. The head is sized to rest on the top surface of the meter pit lid and is configured to hold the stem in the hole. The bracket is configured to hold the transmitter plug inside the meter pit. The stem is selectively engageable with the base so that when the stem is connected with the base, both the plug and bracket are configured to hold and suspend the transmitter plug inside the meter box.
摘要翻译： 提供了一种配置用于将发射器插头悬挂在米坑内的米坑盖塞和支架组件。 米坑盖插头和支架组件包括插头和支架。 插头包括从头部延伸的头部和杆部。 杆也构造成延伸穿过具有顶表面的米坑的孔。 头部的尺寸设置为搁置在仪表凹坑盖的顶表面上并且构造成将杆保持在孔中。 支架配置为将发射器插头固定在仪表坑内。 杆可选择性地与基座接合，使得当杆与基座连接时，插头和支架都构造成将变送器插头保持并悬挂在仪表箱内。
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公开(公告)号：US07647891B2
公开(公告)日：2010-01-19
申请号：US12045875
申请日：2008-03-11
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的尖端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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9.发明申请USE OF CALMODULIN KINASE II INHIBITORS TO TREAT OR PREVENT HEART MUSCLE INFLAMMATION 审中-公开使用钙调素激酶II抑制剂治疗或预防心脏肌肉炎症公开(公告)号：US20090275514A1
公开(公告)日：2009-11-05
申请号：US12433265
申请日：2009-04-30
申请人： Mark E. Anderson , Madhu V. Singh
发明人： Mark E. Anderson , Madhu V. Singh
IPC分类号： A61K38/16 , A61K31/185 , A61K31/496 , A61P9/00
CPC分类号： A61K38/16 , A61K31/185 , A61K31/496 , A61K38/04
摘要： Provided are compositions and methods of treating inflammation of the heart of a subject diagnosed with inflammation of the heart, comprising administering to the subject an effective amount of an inhibitor of Calmodulin Kinase II, whereby the administration of the inhibitor treats inflammation of the heart in the subject. Also provided are compositions and methods of preventing inflammation of the heart of a subject, comprising administering to the subject an effective amount of an inhibitor of Calmodulin Kinase II, whereby the administration of the inhibitor prevents inflammation of the heart in the subject.
摘要翻译： 提供了治疗被诊断患有心脏炎症的受试者的心脏的炎症的组合物和方法，包括向受试者施用有效量的钙调素激酶II的抑制剂，由此所述抑制剂的给药治疗所述心脏的炎症 学科。 还提供了预防受试者心脏炎症的组合物和方法，其包括向受试者施用有效量的钙调蛋白激酶II抑制剂，由此该抑制剂的施用可防止受试者心脏的炎症。
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公开(公告)号：US08136483B2
公开(公告)日：2012-03-20
申请号：US13165057
申请日：2011-06-21
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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