公开(公告)号：US11280741B2

公开(公告)日：2022-03-22

申请号：US16616232

申请日：2018-07-17

申请人： HORIBA Advanced Techno, Co., Ltd.

发明人： Kazuya Nakagawa ,  Hideki Nakayama ,  Kimihiko Arimoto ,  Yoko Nakai

IPC分类号： G01N21/76 ,  G01N21/01 ,  G01N35/04 ,  G01N21/17 ,  G01N21/13 ,  G01N35/02 ,  B01L9/06

摘要： The present invention is one that intends to achieve improvements in both analysis efficiency and analysis accuracy without difficulty, and a biological substance analysis device that analyzes light derived from a biological substance in a sample, and the biological substance analysis device includes: a holder that holds multiple containers containing the sample; a photodetector that is fixed at a predetermined position; a holder driving mechanism that moves the holder to position each of the containers held in the holder at a detection position by the photodetector in sequence; and a light shielding mechanism that, while guiding light emitted from the sample in a container at the detection position to the photodetector, prevents light emitted from the sample in the other containers from being guided to the photodetector.

公开(公告)号：US11243209B2

公开(公告)日：2022-02-08

申请号：US16008891

申请日：2018-06-14

申请人： Alverix, Inc.

发明人： Bo U. Curry ,  Rene B. Helbing

IPC分类号： G01N33/58 ,  G01N35/00 ,  G01N21/00 ,  G01N21/76 ,  G01N33/558

摘要： A method to calibrate measurements of a test analyte in a test sample including measuring at least one test-light level responsive to reactions of at least one reagent group and at least one reactive test analyte in the test sample and measuring at least one control-light level responsive to reactions of at least one reagent group and at least one control analyte in a control sample. Each control analyte is a known amount of at least one reactive test analyte. The method further includes determining a presence of the reactive test analyte in the test sample based on the measured test-light levels and control-light levels. The reagent group and the reactive test analyte react by attaching to each other.

公开(公告)号：US11231373B2

公开(公告)日：2022-01-25

申请号：US16202255

申请日：2018-11-28

申请人： SYSMEX CORPORATION

发明人： Tomoyuki Nose ,  Yusuke Muda ,  Kanako Nagaoka ,  Noriyuki Narisada ,  Varun Nambigari

IPC分类号： G01N33/53 ,  G01N21/75 ,  G01N21/07 ,  G01N35/00 ,  B01L3/00 ,  G01N1/40 ,  G01N33/543 ,  G01N35/02 ,  G01N21/76 ,  G01N21/64 ,  B01L7/00

摘要： A method according to one or more aspects may be a method of measuring a detection material contained in a sample by using a cartridge including: chambers each capable of housing at least one of the detection material and a reagent; and a path through which the detection material is transferred between the chambers. The method may include: moving at least one of the chambers and the path to a measurement position and an image capturing range by rotating the cartridge about a rotational shaft; measuring the detection material in the measurement position; and capturing an image of a monitoring target comprising at least one of the chambers and the path in the image capturing range.

公开(公告)号：US20220018785A1

公开(公告)日：2022-01-20

申请号：US17363758

申请日：2021-06-30

申请人： Meso Scale Technologies, LLC.

发明人： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC分类号： G01N21/76 ,  G01N33/58 ,  G01N33/543

摘要： The invention relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldibutylethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein.

公开(公告)号：US20210363202A1

公开(公告)日：2021-11-25

申请号：US17281550

申请日：2019-09-26

申请人： Inter-University Research Institute Corporation Research Organization of Information and Systems

发明人： Kazuhide ASAKAWA ,  Koicbi KAWAKAMI

IPC分类号： C07K14/46 ,  A01K67/027 ,  G01N21/76 ,  G01N21/01

摘要： What is provided is a fusion protein including any one of proteins of (A) to (C) below; and a tag protein that dimerizes or multimerizes in response to a stimulus, (A) a protein that consists of an amino acid sequence represented by SEQ ID NO: 1; (B) a protein that consists of an amino acid sequence having 70% or more identity with the amino acid sequence represented by SEQ ID NO: 1 and has an aggregate-forming ability, and (C) a protein that consists of an amino acid sequence obtained by performing deletion, substitution, insertion, or addition of one or several amino acids with respect to the amino acid sequence represented by SEQ ID NO: 1 and has the aggregate-forming ability.

公开(公告)号：US11181481B2

公开(公告)日：2021-11-23

申请号：US16489420

申请日：2018-03-08

申请人： Optofluidic Bioassay, LLC

发明人： Maung Kyaw Khaing Oo ,  Xudong Fan

IPC分类号： G01N21/77 ,  B01L3/00 ,  G01N21/78 ,  G01N21/76 ,  G01N21/75

摘要： An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens.

公开(公告)号：US11162951B2

公开(公告)日：2021-11-02

申请号：US16612018

申请日：2018-05-18

申请人： PARIS SCIENCES ET LETTRES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  SORBONNE UNIVERSITE

发明人： Arnaud Gautier ,  Ludovic Jullien ,  Chenge Li ,  Franck Perez

IPC分类号： G01N33/68 ,  G01N21/76 ,  G01N33/52 ,  C07D277/36

摘要： Fluorescent labeling of proteins. In particular, membrane-impermeant fluorogenic chromophores being capable of binding reversibly a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labeling biological molecules of interest, preferably proteins of interest. Especially, 4-hydroxybenzylidene-rhodanine (HBR) analogs of formula (II) as membrane-impermeant fluorogenic chromophores.

公开(公告)号：US11162926B2

公开(公告)日：2021-11-02

申请号：US16404920

申请日：2019-05-07

申请人： SHIMADZU CORPORATION

发明人： Ryo Tanabe

IPC分类号： G01N21/76 ,  G01N21/01 ,  G01N33/00

摘要： In a chemiluminescence type nitrogen oxide concentration meter, a mixed gas of air with its moisture adsorbed by an adsorption apparatus and air that through a fifth flow path without the adsorption apparatus in between is flown into an ozone generator. Therefore, ozone can be generated using air of proper humidity in the ozone generator 7. As a result, ozone can be efficiently generated while suppressing occurrence of metal contamination in the ozone generator 7. Then, in the reaction unit 8, nitrogen oxides in the sample gas are made to appropriately show chemiluminescence using the ozone, and in the detector 9, the intensity of light generated in the reaction unit 8 is detected. Furthermore, in the control unit 10, the concentration of nitrogen oxides in the sample gas is measured, based on the intensity of light detected by the detector 9.

公开(公告)号：US11162147B2

公开(公告)日：2021-11-02

申请号：US16431678

申请日：2019-06-04

申请人： Shengxi Chen

发明人： Shengxi Chen

IPC分类号： C12Q1/70 ,  G01N21/76

摘要： The present disclosure provides a low cost, high sensitivity, high specificity and rapid diagnostic apparatus and method to detect nucleic acids in a sample at room temperature. As low as tens of copies of nucleic acids can be detected without any additional equipment.

公开(公告)号：US20210325390A1

公开(公告)日：2021-10-21

申请号：US17233479

申请日：2021-04-17

申请人： Michael L. Bell

发明人： Michael L. Bell

IPC分类号： G01N33/569 ,  G01N33/58 ,  G01N33/543 ,  G01N21/76 ,  G01N15/14

摘要： The invention includes methods and kits for the detection of a virus that may be in a sample. In embodiments, the invention includes a method of detecting a virus in a sample by forming a reaction mixture exposing an aliquot of the sample purportedly containing a virus to an immobilized receptor. A soluble receptor including a detectable label is added to the reaction mixture. A washing step washes the immobilized receptor, and the detectable label is detected.