公开(公告)号：US08299113B2

公开(公告)日：2012-10-30

申请号：US12226626

申请日：2007-04-30

Applicant: Miguel Angel Pericas-Brondo ,  Antonio Torrens-Jover ,  Susana Yenes-Minguez ,  Félix Cuevas Cordobes ,  Carmen Garcia Granda

Inventor： Miguel Angel Pericas-Brondo ,  Antonio Torrens-Jover ,  Susana Yenes-Minguez ,  Félix Cuevas Cordobes ,  Carmen Garcia Granda

IPC: A01N43/38 ,  A61K31/40 ,  C07D209/00

CPC classification number: C07D209/52 ,  C07D207/20

Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及通式（I）的取代的双环四氢吡咯化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。

公开(公告)号：US08232307B2

公开(公告)日：2012-07-31

申请号：US12667587

申请日：2008-07-04

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover

IPC: A61K31/415 ,  C07D231/00

CPC classification number: C07D231/12 ,  C07D211/42 ,  C07D261/08

Abstract: The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment of humans or animals.

Abstract translation: 本发明涉及通式（I）的茚满胺化合物及其组合物，其制备方法以及所述化合物用于治疗人或动物的用途。

公开(公告)号：US08207156B2

公开(公告)日：2012-06-26

申请号：US13036533

申请日：2011-02-28

Applicant: Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

Inventor： Antoni Torrens ,  Jordi Quintana ,  Helmut Buschmann ,  Albert Dordal ,  Josep Mas

IPC: A61K31/397 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/473 ,  A61K31/4725 ,  A61K31/454 ,  A61K31/4155

CPC classification number: C07D231/06 ,  C07D401/12 ,  C07D403/12 ,  C07D495/04

Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。

公开(公告)号：US08148397B2

公开(公告)日：2012-04-03

申请号：US11658923

申请日：2005-08-18

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

IPC: C07D217/18 ,  A61K31/47

CPC classification number: C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US08138186B2

公开(公告)日：2012-03-20

申请号：US12281246

申请日：2007-03-02

Applicant: Rosa Cuberes-Altisent ,  Joerg Holenz

Inventor： Rosa Cuberes-Altisent ,  Joerg Holenz

IPC: A61K31/5377 ,  C07D413/02

CPC classification number: C07D231/22 ,  C07D231/24 ,  C07D405/12

Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及式（I）化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。

公开(公告)号：US20120059006A1

公开(公告)日：2012-03-08

申请号：US13295315

申请日：2011-11-14

Applicant: Rosa CUBERES-ALTISENT ,  Joerg HOLENZ

Inventor： Rosa CUBERES-ALTISENT ,  Joerg HOLENZ

IPC: A61K31/415 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/496 ,  A61P37/06 ,  A61P25/22 ,  A61P29/00 ,  A61P3/06 ,  A61P3/04 ,  A61P25/06 ,  A61P3/10 ,  A61P25/18 ,  A61P25/24 ,  A61P25/08 ,  A61P9/12 ,  A61P9/10 ,  A61P9/06 ,  A61P25/30 ,  A61P25/28 ,  A61K31/5377

CPC classification number: C07D231/20 ,  C07D401/12

Abstract: The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

Abstract translation: 本发明涉及具有对σ受体的药理学活性的式I化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中涉及σ受体的疾病的用途 。

公开(公告)号：US20120004211A1

公开(公告)日：2012-01-05

申请号：US13229917

申请日：2011-09-12

Applicant: Nadine Jagerovic ,  Jose Maria Cumella-Montanchez ,  Maria Pilar Goya-Laza ,  Alberto Dordal Zueras ,  Maria Rosa Cuberes-Altisent

Inventor： Nadine Jagerovic ,  Jose Maria Cumella-Montanchez ,  Maria Pilar Goya-Laza ,  Alberto Dordal Zueras ,  Maria Rosa Cuberes-Altisent

IPC: A61K31/55 ,  A61K31/454 ,  A61K31/4196 ,  A61P37/06 ,  A61P25/22 ,  A61P1/12 ,  A61P3/06 ,  A61P3/10 ,  A61P3/04 ,  A61P25/28 ,  A61P25/06 ,  A61P19/02 ,  A61P9/12 ,  A61P25/30 ,  A61P25/08 ,  A61P29/00 ,  A61P35/00 ,  A61P25/18 ,  A61K31/5377

CPC classification number: C07D249/06

Abstract: The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula I to processes of preparation of such compounds and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及对σ受体具有药理活性的化合物的用途，更具体地说，涉及式I的1,2,4-三唑衍生物的制备方法以及包含它们的药物组合物。

公开(公告)号：US20110183991A1

公开(公告)日：2011-07-28

申请号：US13063947

申请日：2009-07-31

Applicant: Rosalia Pascual-Ramon ,  Helmut H. Buschmann

Inventor： Rosalia Pascual-Ramon ,  Helmut H. Buschmann

IPC: A61K31/496 ,  C07D403/06 ,  A61P13/00 ,  C07D401/06 ,  A61P1/00 ,  A61P9/12 ,  A61P25/28 ,  A61P25/18 ,  A61P25/00 ,  A61P25/24 ,  A61P25/06 ,  A61P25/22

CPC classification number: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/515

Abstract: The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT7受体具有药理活性的化合物，特别是作为通过使用药效团和描述符轮廓过滤器鉴定的激动剂以及包含它们的药物组合物。 这些化合物特别用于治疗和/或预防其中涉及5-HT7的疾病，例如CNS疾病。

公开(公告)号：US20110172270A1

公开(公告)日：2011-07-14

申请号：US12985646

申请日：2011-01-06

Applicant: Antoni Jover Torrens ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany ,  Helmut-Heinrich Buschmann

Inventor： Antoni Jover Torrens ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Angeles Fisas Escasany ,  Helmut-Heinrich Buschmann

IPC: A61K31/4709 ,  C07D401/12 ,  A61K31/454 ,  C07D211/58 ,  A61K31/4468 ,  A61P3/00 ,  A61P25/00 ,  A61P19/02 ,  A61P9/00

CPC classification number: C04B35/632 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12

Abstract: 1,4-disubstituted piperidine compounds of general formula (I) wherein the substituents are defined in claim 1 that are suitable in particular as active substances in medicaments, preferably in medicaments for the regulation of neuropeptide Y receptors, particularly preferably of neuropeptide Y5 (NPY5) receptor, for the regulation of food ingestion (food intake), preferably for the prophylaxis and/or treatment of disorders of food ingestion, such as obesity, anorexia, cachexia, bulimia or type II (non insulin dependent) diabetes, for the prophylaxis and/or treatment of disorders of the peripheral nervous system, disorders of the central nervous system, anxiety, depression, cognitive disorders, preferably memory disorders, cardiovascular diseases, pain, epilepsy, arthritis, hypertensive syndrome, inflammatory diseases, immune diseases and other NPY5 mediated disorders in animals and mammals, including man.

Abstract translation: 通式（I）的1,4-二取代哌啶化合物，其中取代基在权利要求1中定义，其特别适用于药物中的活性物质，优选用于调节神经肽Y受体的药物，特别优选神经肽Y5（NPY5 ）受体，用于调节食物摄入（食物摄入），优选用于预防和/或治疗食物摄取的疾病，例如肥胖症，厌食症，恶病质，贪食症或II型（非胰岛素依赖性）糖尿病，用于预防 和/或治疗周围神经系统疾病，中枢神经系统疾病，焦虑症，抑郁症，认知障碍，优选记忆障碍，心血管疾病，疼痛，癫痫，关节炎，高血压综合征，炎性疾病，免疫疾病和其他NPY5 包括人在内的动物和哺乳动物介导的疾病。

公开(公告)号：US20110092540A1

公开(公告)日：2011-04-21

申请号：US12991655

申请日：2009-05-08

Applicant: Josep Mas Prio ,  Antoni Torrens Jover

Inventor： Josep Mas Prio ,  Antoni Torrens Jover

IPC: A61K31/4725 ,  C07D401/14 ,  C07D513/04 ,  A61K31/429 ,  A61P3/04 ,  A61P3/10 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07D513/04 ,  C07D519/00

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT6; receptor, and more particularly to some N-phenyl-2,3-dihydroimidazol[2,1-b]thiazole-5-sulfonamide derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT6 is involved.

Abstract translation: 本发明涉及对5-HT6具有药理活性的化合物; 更具体地涉及一些N-苯基-2,3-二氢咪唑并[2,1-b]噻唑-5-磺酰胺衍生物，制备这些化合物的方法，包括它们的药物组合物及其用于 治疗和/或预防其中涉及5-HT6的疾病。