公开(公告)号：US20200296915A1

公开(公告)日：2020-09-24

申请号：US16359690

申请日：2019-03-20

申请人： University of Georgia Research Foundation, Inc.

发明人： Zenglu Li ,  Edwin D. Wood ,  H. Roger Boerma ,  James P. Noe ,  James W. Buck

IPC分类号： A01H6/54 ,  A01H5/10

摘要： Herein provided is a new soybean variety designated ‘G13LL-44’ as well as the seeds, plants and derivatives of the new soybean variety ‘G13LL-44’. Also provided are tissue cultures of the new soybean variety ‘G13LL-44’ and the plants regenerated therefrom. Methods for producing soybean plants by crossing the new soybean variety ‘G13LL-44’ with itself or another soybean variety and plants produced by such methods are also provided. ‘G13LL-44’ is a MG VII line with glufosinate tolerance technology, and with resistance to race 3 of the soybean cyst nematode and frogeye leaf spot, and moderate resistance to southern root-knot nematode. ‘G13LL-44’ yielded 1.4 bu/ac (2.3%) greater than its recurrent parent ‘G00-3213’, across 11 environments and 0.5 bu/ac more than the high-yielding check cultivar ‘AG738 RR’. ‘G13LL-44’ provides a high yielding glufosinate tolerant soybean cultivar with superior nematode resistance.

公开(公告)号：USPP32111P2

公开(公告)日：2020-08-25

申请号：US16602649

申请日：2019-11-14

申请人： University of Georgia Research Foundation, Inc.

发明人： Patrick J. Conner

IPC分类号： A01H6/88 ,  A01H5/08

摘要： A new and distinct muscadine grape plant, substantially as herein illustrated and described, characterized by dark red-colored berries; self-fertile flowers; berries that separate with a high percentage of dry stem scars; berries that are very large in size, and very productive vines with high total and usable yields.

公开(公告)号：US10676719B2

公开(公告)日：2020-06-09

申请号：US15223515

申请日：2016-07-29

申请人： University of Georgia Research Foundation, Inc. ,  Augusta University Research Institute, Inc.

发明人： Leidong Mao ,  Carsten Schroeder ,  Wujun Zhao

IPC分类号： B01L3/00 ,  C12N5/09 ,  C12N5/095

摘要： Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.

公开(公告)号：US10548993B2

公开(公告)日：2020-02-04

申请号：US15500691

申请日：2015-07-30

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： Jin Xie ,  Hongmin Chen ,  Geoffrey D. Wang

IPC分类号： A61B5/00 ,  A61K49/18 ,  A61B5/055 ,  G01R33/56

摘要： Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.

公开(公告)号：US10542932B2

公开(公告)日：2020-01-28

申请号：US15616318

申请日：2017-06-07

申请人： University of Georgia Research Foundation, Inc.

发明人： Kevin K. McCully ,  Terence E. Ryan

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  A61B17/135 ,  A61B5/02

摘要： In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements.

公开(公告)号：US10533008B2

公开(公告)日：2020-01-14

申请号：US16083128

申请日：2017-03-01

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, IONC.

发明人： Chung K. Chu ,  Varughese Alexander Mulamootttil ,  Ram C. Mishra ,  Uma Sharan Singh

IPC分类号： C07D473/34 ,  C07D317/44 ,  C07C41/26 ,  C07C41/30 ,  C07D473/18 ,  C07D473/26 ,  C07D473/40 ,  C07F9/6561 ,  C07C41/28 ,  A61P31/20 ,  C07C43/196

摘要： The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R,4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

公开(公告)号：US20190352603A1

公开(公告)日：2019-11-21

申请号：US16414576

申请日：2019-05-16

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  ARUNA BIOMEDICAL, INC.

发明人： Steven L. Stice ,  Robin Lynn Webb ,  Tracy A. Stice

IPC分类号： C12N5/0793 ,  A61K35/545 ,  A61K35/12 ,  C12N5/079

摘要： Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.

公开(公告)号：USPP31097P3

公开(公告)日：2019-11-19

申请号：US15932493

申请日：2018-03-06

申请人： University of Georgia Research Foundation, Inc.

发明人： Wayne W. Hanna ,  Brian M. Schwartz

IPC分类号： A01H5/12 ,  A01H6/46

摘要： A new variety of Pennisetum alopecuroides plant named ‘Tift PA18’ produces a reduced number of seeds, making it less invasive.

公开(公告)号：US20190281752P1

公开(公告)日：2019-09-12

申请号：US15932493

申请日：2018-03-06

申请人： University of Georgia Research Foundation, Inc.

发明人： Wayne W. Hanna ,  Brian M. Schwartz

IPC分类号： A01H6/46

摘要： A new variety of Pennisetum alopecuroides plant named ‘Tift PA18’ produces a reduced number of seeds, making it less invasive.

公开(公告)号：US20190269056P1

公开(公告)日：2019-08-29

申请号：US15932408

申请日：2018-02-26

申请人： University of Georgia Research Foundation, Inc.

发明人： John M. Ruter

IPC分类号： A01H6/60

摘要： A new Hibiscus plant named ‘RutHib1’ is characterized by a combination of good form, medium vigor, predominately purple foliage, white flowers with a red eye, and good tolerance to Alternaria, Cercospora, and Phytophthora pathogens.