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公开(公告)号：US20210106693A1
公开(公告)日：2021-04-15
申请号：US17094196
申请日：2020-11-10
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20210070872A1
公开(公告)日：2021-03-11
申请号：US16999374
申请日：2020-08-21
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker SEIBERT , Olivier LÉGER , Marc VAN DIJK , Taha MERGHOUB , David SCHAER , Gerd RITTER , Takemasa TSUJI
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20210054074A1
公开(公告)日：2021-02-25
申请号：US17078602
申请日：2020-10-23
申请人： Agenus Inc.
发明人： Nicholas Stuart Wilson , David Adam Savitsky , Shawn Michael Jennings , Marc van Dijk , Cornelia Anne Mundt
摘要： The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10912831B1
公开(公告)日：2021-02-09
申请号：US17030650
申请日：2020-09-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10800849B2
公开(公告)日：2020-10-13
申请号：US15962752
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20200263133A1
公开(公告)日：2020-08-20
申请号：US15759007
申请日：2016-09-09
申请人： AGENUS INC.
IPC分类号： C12N5/0783 , C07K14/705 , C07K14/725 , C12N15/86 , G01N33/50 , C12N15/10
摘要： Provided herein are engineered host cells suitable for expression of functional T cell receptors (TCR) and methods of using these cells to identify TCRs that specifically bind to a desired peptide-major histocompatibility complex (MHC) complex.
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公开(公告)号：US10450373B2
公开(公告)日：2019-10-22
申请号：US16399262
申请日：2019-04-30
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Baek Holmgaard , David Schaer , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20190256601A1
公开(公告)日：2019-08-22
申请号：US16399262
申请日：2019-04-30
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： MARC VAN DIJK , CORNELIA ANNE MUNDT , GERD RITTER , JEDD DAVID WOLCHOK , TAHA MERGHOUB , ROBERTA ZAPPASODI , RIKKE BAEK HOLMGAARD , DAVID SCHAER , DAVID ADAM SAVITSKY , NICHOLAS STUART WILSON
IPC分类号： C07K16/28
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10323091B2
公开(公告)日：2019-06-18
申请号：US15254315
申请日：2016-09-01
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Nicholas Stuart Wilson , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Bæk Holmgaard , David Schaer , David Adam Savitsky
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10280226B2
公开(公告)日：2019-05-07
申请号：US16175453
申请日：2018-10-30
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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