公开(公告)号：US20150299762A1

公开(公告)日：2015-10-22

申请号：US14417989

申请日：2013-07-31

申请人： ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON I ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Jens HASSERODT

IPC分类号： C12Q1/40 ,  C07H15/26

CPC分类号： C12Q1/40 ,  C07H15/26 ,  C12Q1/34 ,  G01N2333/924 ,  G01N2333/938 ,  G01N2400/00 ,  G01N2458/30

摘要： The invention concerns novel glycosidase substrates of formula (I): where R0, R1, R2, R3, and R4 are such as defined in claim 1; and a method for detecting the presence of a catalytically active glycosidase using one of these substrates.

摘要翻译： 本发明涉及式（I）的新型糖苷酶底物：其中R 0，R 1，R 2，R 3和R 4如权利要求1中所定义; 以及使用这些底物之一检测催化活性糖苷酶的存在的方法。

公开(公告)号：US20140298497A1

公开(公告)日：2014-10-02

申请号：US14355938

申请日：2012-11-02

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE DE CACHAN ,  MEDIZINISCHE UNIVERSITÄT WIEN

发明人： Michel Arock ,  Peter Valent ,  Rosine Saleh ,  Ghaith Wedeh ,  Christian Auclair

IPC分类号： A61K49/00 ,  G01N33/50

CPC分类号： A61K49/0008 ,  C12N5/0642 ,  G01N33/5008 ,  G01N33/5047

摘要： The present invention relates to a human mast cell line corresponding to deposit number CNCM I-4551 and also to the lines derived therefrom, in particular the derived lines corresponding respectively to deposit numbers CNCM I-4552 and CNCM I-4553, and to the uses thereof, in particular for screening for compounds of therapeutic interest.

摘要翻译： 本发明涉及对应于存款编号CNCM I-4551的人类肥大细胞系以及与其相关的线，特别是涉及分别对应于保藏号CNCM I-4552和CNCM I-4553的衍生线，以及用于 特别是用于筛选治疗感兴趣的化合物。

公开(公告)号：US20140186364A1

公开(公告)日：2014-07-03

申请号：US14134869

申请日：2013-12-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  ECOLE NORMALE SUPERIEURE DE LYON ,  CENTRE LEON BERARD

发明人： Patrick Etienne-Roger MEHLEN ,  Servane Marie-Séverine Tauszig-Delamasure ,  Céline Jacqueline-Andrée Delloye ,  Jimena Bouzas-Rodriguez

IPC分类号： C07K16/22 ,  C07K16/30 ,  A61K38/17

CPC分类号： C07K16/22 ,  A61K38/179 ,  C07K16/30 ,  C12N15/1137 ,  C12N2310/14 ,  G01N33/5011 ,  G01N33/57484 ,  G01N2333/48 ,  G01N2500/02

摘要： The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

摘要翻译： 本公开的主题涉及基于这些化合物与神经营养因子3（NT-3或NT3）相互作用到细胞外结构域或TrkC受体的能力的抗癌化合物的体外方法和/ 或抑制在肿瘤细胞中表达的TrkC受体的细胞内结构域的二聚，特别是在成神经细胞瘤中。 本公开还涉及用于预测转移性癌症或不良预后癌症的存在或基于测量神经营养因子3的表达水平来确定抗癌治疗效率的方法。本发明还包括试剂盒和化合物 作为用于治疗由肿瘤细胞过度表达神经营养因子3的神经母细胞瘤或癌症的药物。

公开(公告)号：US11649253B2

公开(公告)日：2023-05-16

申请号：US16628854

申请日：2018-07-05

申请人： ECOLE NORMALE SUPERIEURE DE LYON ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE CLAUDE BERNARD LYON 1

发明人： Amandine Roux ,  Anh-Thy Bui ,  Olivier Maury ,  Chantal Andraud

IPC分类号： C01F5/00 ,  C07F5/00 ,  G01N21/76

CPC分类号： C07F5/003 ,  G01N21/76

摘要： The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule.

公开(公告)号：US20230060715A1

公开(公告)日：2023-03-02

申请号：US17787956

申请日：2021-01-14

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ENYO PHARMA

发明人： RAPHAËL DARTEIL ,  JULIE LUCIFORA ,  DAVID DURANTEL ,  CHRISTOPHE RAMIERE ,  BENOÎT LACOMBE ,  VINCENT LOTTEAU ,  PATRICE ANDRE

IPC分类号： A61K31/42 ,  A61K38/21 ,  A61K31/575 ,  A61K31/4748 ,  A61K31/506 ,  A61K31/496

摘要： The present invention relates to the use of a farnesoid X receptor (FXR) agonist for the treatment of hepatitis D infection.

公开(公告)号：US11526980B2

公开(公告)日：2022-12-13

申请号：US16771415

申请日：2018-12-07

申请人： Electricite de France ,  Centre National de la Recherche Scientifique (CNRS) ,  Ecole Normale Superieure De Cachan

发明人： Félix Latourte ,  Qiwei Shi ,  François Hild ,  Stéphane Roux

IPC分类号： G06T5/00 ,  G06T7/00 ,  G01N23/203 ,  G01N23/2251 ,  G06T5/50

摘要： The invention relates to a method for processing images obtained by a diffraction detector, of a crystalline or polycrystalline material, in which a first image of the material is acquired in a state of reference as well as a second image of the material in a deformed state. The invention is characterised in that, in a calculator, during a first step (E6, E12), a current elastic deformation gradient tensor Fe is given a value determined by calculation, during a second step (E7), the current displacement field induced by the tensor Fe is calculated, during a third step (E8), third digital values of a deformed image {hacek over (g)}(x)=g(x+u(x)) corrected by the current displacement field are calculated, and during an iterative algorithm, iterations of the second and third steps (E12, E7, E8) are carried out on modified values of the tensor r Fe until a convergence criterion is met in relation to the correction to the current value of Fe.

公开(公告)号：US20220349920A1

公开(公告)日：2022-11-03

申请号：US17774182

申请日：2020-11-04

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE PARIS-SACLAY

发明人： Vincent LOYAU ,  Gérard CHAPLIER ,  Frédéric MAZALEYRAT

IPC分类号： G01R15/20

摘要： The invention concerns a current detector (10) suited to measure a current circulating in an electrical conductor (12), the current detector (10) including: a probe (14) including: a converter (18) suited to convert the magnetic field induced by the current to be measured in the conductor (12) into a voltage, wherein the converter (18) is a magnetostrictive, piezoelectric composite material, and a circuit (16) for detecting the voltage converted by the converter (18).

公开(公告)号：US11451722B2

公开(公告)日：2022-09-20

申请号：US17277462

申请日：2019-09-17

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  SORBONNE UNIVERSITE ,  ECOLE NORMALE SUPERIEURE ,  UNIVERSITE DE PARIS ,  UNIVERSITE DE BOURGOGNE ,  OBSERVATOIRE DE PARIS

发明人： David Darson ,  Julien Dubois ,  Francois Colas

IPC分类号： H04N5/345 ,  H04N5/232 ,  H04N5/357 ,  H04N5/374

摘要： The invention relates to a method for acquiring an image by an imager (20) comprising a matrix of pixels configured to generate an electric response when exposed to an incident light flux travelling through an optical path (21) in which is arranged a wavefront correction element (22), comprising the following steps: 1) initiating the exposure of the pixels to the incident light flux; 2) for a plurality of iterations during the exposure: 2.1) non-destructive reading of the electric responses of pixels of a region of interest; 2.2) determining an evolution of the spatial distribution of pixels in logarithmic mode previous iteration with respect to the previous iteration; 2.3) based on said evolution, establishing a command for the wavefront correction element (22) in order to correct the wavefront; 2.4) configuring the wavefront correction element, 3) reading the electric responses of the pixels resulting in an image.

公开(公告)号：US20220057261A1

公开(公告)日：2022-02-24

申请号：US17414588

申请日：2019-12-17

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITE ,  COLLEGE DE FRANCE ,  ECOLE NORMALE SUPERIEURE

发明人： Raphaël LESCANNE ,  Samuel DELEGLISE ,  Emmanuel FLURIN ,  Zaki LEGHTAS

IPC分类号： G01J1/44

摘要： A superconducting detection device for detecting a single microwave photon, including: —a quantum system with two energy levels of which the ground state and an excited state are controllable and detectable, the quantum system being designed to allow modulable three-wave interaction; —a buffer resonator arranged to receive an incident single microwave photon; —a highly dissipative auxiliary resonator arranged to discharge a photon; and—a reading device arranged to detect the state of the two-level quantum system; the buffer resonator and the auxiliary resonator are coupled to the quantum system; and the excited state of the quantum system and the photon of the auxiliary resonator are created in response to the reception of the incident photon in the buffer resonator and to the application of parametric pumping to the device. A method for detecting a single microwave photon implemented by a device according to the invention.

公开(公告)号：US20210352229A1

公开(公告)日：2021-11-11

申请号：US17277462

申请日：2019-09-17

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  SORBONNE UNIVERSITE ,  ECOLE NORMALE SUPERIEURE ,  UNIVERSITE DE PARIS ,  UNIVERSITE DE BOURGOGNE ,  OBSERVATOIRE DE PARIS

发明人： David DARSON ,  Julien DUBOIS ,  Francois COLAS

IPC分类号： H04N5/345 ,  H04N5/357 ,  H04N5/374 ,  H04N5/232

摘要： The invention relates to a method for acquiring an image by an imager (20) comprising a matrix of pixels configured to generate an electric response when exposed to an incident light flux travelling through an optical path (21) in which is arranged a wavefront correction element (22), comprising the following steps: 1) initiating the exposure of the pixels to the incident light flux; 2) for a plurality of iterations during the exposure: 2.1) non-destructive reading of the electric responses of pixels of a region of interest; 2.2) determining an evolution of the spatial distribution of pixels in logarithmic mode previous iteration with respect to the previous iteration; 2.3) based on said evolution, establishing a command for the wavefront correction element (22) in order to correct the wavefront; 2.4) configuring the wavefront correction element, 3) reading the electric responses of the pixels resulting in an image.