公开(公告)号：US11608509B2

公开(公告)日：2023-03-21

申请号：US16094636

申请日：2017-04-20

申请人： Ecole Normale Superieure de Lyon ,  Centre National de la Recherche Scientifique (CNRS) ,  Université Claude Bernard Lyon 1 ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

发明人： Caroline Costa Fejoz ,  Els Verhoeyen ,  François-Loïc Cosset ,  Ruben Bender ,  Christian Buchholz ,  Qi Zhou

IPC分类号： C12N15/86 ,  A61P35/00 ,  C07K14/005 ,  C07K14/54 ,  C07K16/28 ,  C07K16/32 ,  A61K39/00

摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.

公开(公告)号：US20230045428A1

公开(公告)日：2023-02-09

申请号：US17790588

申请日：2020-12-20

申请人： Brochier Technologies ,  Centre National de la Recherche Scientifique ,  Universite Claude Bernard Lyon 1 ,  Institut National De La Sante Et De La Recherche Medicale ,  Ecole Normale Superieure De Lyon

发明人： Chantal GUILLARD ,  Christophe GILBERT ,  Cédric BROCHIER ,  Laure PERUCHON ,  Lina LAMAA ,  Davide LORITO

IPC分类号： A61L9/20 ,  A61L2/26 ,  A61L2/10 ,  A61L2/08 ,  A61L2/238 ,  C02F1/72 ,  C02F1/32 ,  B01D53/88 ,  B01D53/00

摘要： A system for the treatment of microorganisms includes: a textile web having optical fibers in warp and/or weft woven with binding threads in warp and/or weft, each of the optical fibers having invasive alterations along the fiber and allowing the emission of light propagating in the fiber at these alterations; a light source arranged opposite one or both free ends of the optical fibers. The textile web includes metallic warp and/or weft threads woven with the binding threads, the metallic threads being based on a metal having a negative effect on the growth of microorganisms. The light source generates a light beam having at least one wavelength in the visible or ultraviolet spectrum.

公开(公告)号：US20230013304A1

公开(公告)日：2023-01-19

申请号：US17780148

申请日：2020-11-30

申请人： UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE ,  INSERM ( INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE ROUEN-NORMANDIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (INSA) ,  ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1

发明人： Stéphane GERARD ,  Jean-Philippe BOUILLON ,  Abderrazzaq BENTAHER ,  Eric HENON ,  Jacky JACQUOT ,  Janos SAPI ,  Frédéric VELARD

IPC分类号： C07D237/14 ,  A61K31/501 ,  A61K45/06 ,  C07D409/06 ,  C07D401/04

摘要： The invention relates to compounds of Formula I: or pharmaceutically acceptable solvates thereof, as well as their use in the treatment and/or prevention of diseases or conditions associated with a dysfunction of CFTR channel activity, in particular cystic fibrosis.

公开(公告)号：US11497779B2

公开(公告)日：2022-11-15

申请号：US16639277

申请日：2018-08-17

申请人： Ecole Normale Superieure de Lyon ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite Claude Bernard Lyon 1

发明人： François Leulier ,  Maria Elena Martino

IPC分类号： A61K35/747 ,  C12N1/20 ,  A23L33/135 ,  A61K35/00

摘要： The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.

公开(公告)号：US20220334051A1

公开(公告)日：2022-10-20

申请号：US17642213

申请日：2020-07-31

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE DE PARIS ,  SORBONNE UNIVERSITE

发明人： Ludovic JULLIEN ,  Raja CHOUKET ,  Agathe ESPAGNE ,  Annie LEMARCHAND ,  Thomas LE SAUX ,  Agnès PELLISSIER-TANON

IPC分类号： G01N21/27 ,  G01N21/64

摘要： A method for detecting a photochemically active chemical species in a sample, comprising the steps of: a) illuminating the sample with light at a wavelength suitable to trigger a reaction affecting an optical property of the chemical species according to an illumination sequence, such that: in at least a first time window, the kinetics of the first reaction is limited by a photochemically-activated step of the reaction; and in at least a second time window, the kinetics of the first reaction is limited by a thermally-activated step; b) measuring the evolution of the optical property during the first and the second time windows; c) determining at least a first and a second time constant representing the kinetics of the first reaction in the first and the second time windows, respectively; and d) using the determined time constants for identifying the chemical species. An apparatus for carrying out such a method.

公开(公告)号：US11215446B2

公开(公告)日：2022-01-04

申请号：US16976425

申请日：2018-02-28

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NORMALE SUPERIEURE DE CACHAN

发明人： François Hild ,  Hugo Leclerc ,  Stéphane Roux

IPC分类号： G01B11/16 ,  G06T7/32 ,  G06T7/00 ,  G06F30/23 ,  G06F30/17 ,  G01B15/06 ,  G01M5/00 ,  G06F111/10

摘要： A computer-implemented method for identifying mechanical parameters of an object subjected to mechanical stress is provided. The method comprises a step of acquiring, by an imaging means, images of the object taken before and during the application of the mechanical stress, three steps of calculating the effects due to the stress carried out either on the basis of the modeling of the recorded images or on the basis of a theoretical mechanical modeling of the stress, a step of defining a functional equal to the difference between the two models and a last step of minimizing said functional so that the experimental model is as close as possible to the theoretical mechanical model. Additional measurements make it possible to refine the method.

公开(公告)号：US20210324394A1

公开(公告)日：2021-10-21

申请号：US17268951

申请日：2019-08-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Lionel NAVARRO ,  Meenu SINGLA RASTOGI

IPC分类号： C12N15/82 ,  A01N63/60

摘要： The present invention pertains to the field of agriculture. The invention relates to a method to inhibit gene expression in bacteria, which is referred to here as Antibacterial Gene Silencing (AGS). In particular embodiments, the method is used to protect plants against pathogenic bacteria by targeting pathogenicity factors and/or essential genes in a sequence-specific manner via small non-coding RNAs. The method can also be used to enhance beneficial effects and/or growth of plant-associated symbiotic or commensal bacteria. The invention involves either the generation of stable transgenic plants that constitutively express antibacterial small RNAs or, alternatively, the exogenous delivery of these small RNA entities onto plants, either in the form of RNA extracts or embedded into plant extracellular vesicles (EVs), which were found to be effective in reducing bacterial pathogenicity. The invention also describes a method to identify in a rapid, reliable and cost-effective manner, small RNAs that possess antibacterial activity and that can be further exploited for RNA-based biocontrol applications to confer plant protection against pathogenic bacteria. In addition, the latter approach is instrumental to rapidly characterize any genes from any bacterial species.

公开(公告)号：US20210283239A1

公开(公告)日：2021-09-16

申请号：US17262263

申请日：2019-07-12

申请人： UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE DE LYON ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE LAVAL

发明人： Manuel ROSA-CALATRAVA ,  Guy BOIVIN ,  Julia DUBOIS ,  Mario Andres PIZZORNO ,  Olivier TERRIER ,  Marie-Eve HAMELIN ,  Marie-Helene CAVANAGH

IPC分类号： A61K39/155 ,  C12N7/00 ,  A61P31/14

摘要： The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.

公开(公告)号：US20210234086A1

公开(公告)日：2021-07-29

申请号：US16751982

申请日：2020-01-24

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NATIONALE SUPERIEURE DES MINES DE PARIS ,  ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS-ARMINES ,  ECOLE NORMALE SUPERIEURE ,  SORBONNE UNIVERSITE ,  UNIVERSITE DE PARIS

发明人： Raphaël LESCANNE ,  Zaki LEGHTAS

IPC分类号： H01L39/22 ,  H01L39/02 ,  H03K19/195 ,  H01F6/06 ,  H01B12/02 ,  G01R33/035 ,  G06N10/00

摘要： The present invention relates to an inductive dipole element for a superconducting microwave quantum circuit. The dipole element comprises a DC-SQUID formed by a pair of Josephson junctions shunted by an inductance, wherein the Josephson junctions have equal energy, and the Josephson junctions and the inductance are arranged such that each of the junctions forms a loop with the inductance. The two loops are asymmetrically threaded with external magnetic DC fluxes φext1 and φext2, respectively, such that φext1=π and φext2=0, wherein parametric pumping is enabled by modulating the total flux φΣ=φext,1+φext,2 threading the dipole element, thereby allowing even-wave mixing between modes that participate in the dipole element with no Kerr-like interactions.

公开(公告)号：US20210189156A1

公开(公告)日：2021-06-24

申请号：US16636008

申请日：2018-07-31

申请人： ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Patrice Baldeck ,  Akos Banyasz

IPC分类号： C09D11/101 ,  C09D11/107 ,  B33Y10/00 ,  B29C64/129 ,  B29C64/371 ,  B33Y40/00 ,  B33Y70/00

摘要： A photopolymerizable composition comprises at least a polymerizable resin, a photosensitizer, an annihilator, and a photoinitiator. The photosensitizer is formulated to absorb an excitation light signal received in a first range of wavelengths. The annihilator is formulated to emit a light signal in a second range of wavelengths different from the first. During the absorption of light by the photosensitizer in the first range of wavelengths, the annihilator emits a light signal in the second range, a photon energy of the emitted light signal being greater than a photon energy of the light signal received by the photosensitizer. The annihilator is also formulated to implement an energy transfer mechanism to excite the photoinitiator for polymerization of the resin. The excited photoinitiator is formulated to generate at least one polymerizable initiator to cause the polymerization reaction. Related methods, such as three-dimensional printing methods, and materials are also disclosed.