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公开(公告)号：US20240257984A1
公开(公告)日：2024-08-01
申请号：US18627267
申请日：2024-04-04
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Christopher Hughes CHATHAM , Matteus Jiawei PAN , Katrin Hildegund PRELLER , Michael Anthony RABBIA , Yajing ZHU
Abstract: Methods and systems for simulating training and subpopulations and selecting training scenarios for neurodevelopmental disorders such as autism spectrum disorder (ASD) are described herein. Population data may be received. Skill data indicating skills associated with one or more behaviors exhibited by individuals with one or more neurodevelopmental disorders may be received. Behavioral goals may be identified. Scenario data indicating a plurality of different training scenarios may be generated. Efficacy data may be generated by estimating a probability that skills would be trained by a given training scenario. Estimated clinical success data may be generated by simulating, for each training scenario and for each subject subpopulation, a degree of behavioral change. A combination of a first subject subpopulation and a first training scenario may be selected. The first training scenario may be associated with training a plurality of different skills.
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公开(公告)号：US12038441B2
公开(公告)日：2024-07-16
申请号：US17061795
申请日：2020-10-02
Applicant: Hoffmann-La Roche Inc.
Inventor： Diana Darowski , Camille Loise Sophie Delon , Lydia Jasmin Hanisch , Christian Jost , Christian Klein , Ekkehard Moessner , Vesna Pulko , Wei Xu
IPC: G01N33/574
CPC classification number: G01N33/57492
Abstract: The present invention generally relates to diagnostic assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter cell assays to analyze samples, in particular patient samples, to diagnose cancer by quantifying the expression of tumor antigens and/or predicting clinical response to cancer immunotherapies. A further aspect of the present invention is to improve safety of e.g., cancer immunotherapies.
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公开(公告)号：US20240218060A1
公开(公告)日：2024-07-04
申请号：US18220623
申请日：2023-07-11
Applicant: Hoffmann-La Roche Inc.
Inventor： Tillman Schlothauer
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/92 , C07K2317/94
Abstract: Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein
i) the first and the second polypeptide comprise the mutations H310A, H433A and Y436A, or
ii) the first and the second polypeptide comprise the mutations L251D, L314D and L432D, or
iii) the first and the second polypeptide comprise the mutations L251S, L314S and L432S.-
公开(公告)号：US12026875B2
公开(公告)日：2024-07-02
申请号：US17431334
申请日：2020-03-26
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Eldad Klaiman , Jacob Gildenblat
IPC: G06T7/00 , G06N3/045 , G06V10/44 , G06V10/74 , G06V10/764 , G06V10/774 , G06V10/82 , G06V20/69 , G16H30/40
CPC classification number: G06T7/0012 , G06N3/045 , G06V10/454 , G06V10/761 , G06V10/764 , G06V10/7747 , G06V10/82 , G06V20/695 , G06V20/698 , G16H30/40 , G06T2207/30024 , G06V2201/03
Abstract: The method includes receiving a plurality of digital images each depicting a tissue sample; splitting each of the received images into a plurality of tiles; automatically generating tile pairs, each tile pair having assigned a label being indicative of the degree of similarity of two tissue patterns depicted in the two tiles of the pair, wherein the degree of similarity is computed as a function of the spatial proximity of the two tiles in the pair, wherein the distance positively correlates with dissimilarity; and training a machine learning module—MLM—using the labeled tile pairs as training data to generate a trained MLM, the trained MLM being configured for performing an image analysis of digital histopathology images.
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公开(公告)号：US20240182898A1
公开(公告)日：2024-06-06
申请号：US18540306
申请日：2023-12-14
Applicant: HOFFMANN-LA ROCHE INC.
Inventor： Erik FUNDER , Natascha HRUSCHKA , Susanne KAMMLER , Erich Koller , Brian Leonard , Souphalone LUANGSAY , Susanne MOHR , Tobias NILSSON , Søren OTTOSEN , Lykke PEDERSEN , Søren RASMUSSEN , Steffan SCHMIDT , Sabine SEWING , Daniel Turley , Johanna Marie WALTHER
IPC: C12N15/113 , A61K31/7088 , A61P31/20
CPC classification number: C12N15/113 , A61K31/7088 , A61P31/20 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/351
Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.
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Patent Agency Ranking
公开(公告)号：US11999710B2
公开(公告)日：2024-06-04
申请号：US17125655
申请日：2020-12-17
Applicant: HOFFMANN-LA ROCHE INC. , ETH ZUERICH
Inventor： Simon M. Ametamey , Luca Gobbi , Uwe Grether , Julian Kretz , Dieter Muri , Ahmed Haider Wahauib
IPC: C07D401/04 , C07B59/00
CPC classification number: C07D401/04 , C07B59/002 , C07B2200/05
Abstract: The present invention relates to a compound of formula (I)
wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.-
公开(公告)号：US11993642B2
公开(公告)日：2024-05-28
申请号：US16413469
申请日：2019-05-15
Applicant: Hoffmann-La Roche Inc.
Inventor： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
CPC classification number: C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
Abstract: The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
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公开(公告)号：US20240168036A1
公开(公告)日：2024-05-23
申请号：US18526020
申请日：2023-12-01
Applicant: GENENTECH, INC. , HOFFMANN-LA ROCHE INC.
Inventor： Jia Guo , Regina Kufer , Delia Li , Feng Yang , Inn Huam Yuk , Jinhua Zhang , Lance J. Cadang , Lu Dai
CPC classification number: G01N33/6848 , G01N1/4044 , G01N30/7233 , G01N30/88 , G01N2030/8831
Abstract: The present disclosure relates to highly sensitive methods for determining the identity and quantity of one or more proteins in a sample. For example, the present disclosure provides methods for the highly sensitive identification and quantitation of residual host cell proteins in protein samples and can be adapted to identify and quantify proteins in either a targeted or a target-agnostic manner and can be modified to achieve a range of sensitivities appropriate for distinct use cases.
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公开(公告)号：US11987632B2
公开(公告)日：2024-05-21
申请号：US17125500
申请日：2020-12-17
Applicant: Hoffmann-La Roche Inc.
Inventor： Tina Weinzierl , Lydia Jasmin Hanisch , Alexander Bujotzek , Alejandro Carpy Gutierrez Cirlos , Stefan Klostermann , Christian Klein , Simon Patrick Keiser , Tanja Fauti , Estelle Marrer-Berger , Pablo Umaña
CPC classification number: C07K16/2833 , A61P35/00 , C07K16/2809 , C07K16/30 , A61K2039/505 , C07K2317/31 , C07K2317/55 , C07K2317/73 , C07K2317/92
Abstract: The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US11981737B2
公开(公告)日：2024-05-14
申请号：US16415979
申请日：2019-05-17
Applicant: Hoffmann-La Roche Inc.
Inventor： Jens Fischer , Meher Majety , Stefan Dengl , Georg Tiefenthaler , Stefan Klostermann , Claudia Kirstenpfad , Esther Koenigsberger , Francesca Ros
IPC: C07K16/00 , C07K16/28 , G01N33/574
CPC classification number: C07K16/2833 , G01N33/57484 , C07K2317/33 , C07K2317/622 , C07K2317/76 , G01N2333/70539
Abstract: The present invention relates to anti-HLA-G antibodies and methods of using the same.
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