公开(公告)号：US5587507A

公开(公告)日：1996-12-24

申请号：US414339

申请日：1995-03-31

Applicant: Joachim B. Kohn ,  Kimberly A. Hooper

Inventor： Joachim B. Kohn ,  Kimberly A. Hooper

IPC: C07C231/02 ,  C07C235/34 ,  C08G63/685 ,  C08G64/12 ,  C08G69/44 ,  C07C229/28 ,  C07C229/34

CPC classification number: C08G69/44 ,  C07C231/02 ,  C07C235/34 ,  C08G63/6856 ,  C08G64/12

Abstract: A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.

Abstract translation: 一种制备二酚化合物的方法，该方法包括将羟基苯基羧酸与L-酪氨酸酯偶联在含有可形成水溶性尿素副产物的碳二亚胺的水混溶性有机反应溶剂中，由此形成 二酚反应产物; 并将反应混合物与一定量的水组合，将水作为与水不混溶的有机相沉淀，使得形成含有二酚反应产物的与水不混溶的有机相。 还公开了新的二酚单体和从其聚合的聚合物。

公开(公告)号：US5455027A

公开(公告)日：1995-10-03

申请号：US23069

申请日：1993-02-25

Applicant: Samuel Zalipsky ,  Durgadas Bolikal ,  Aruna Nathan ,  Joachim B. Kohn

Inventor： Samuel Zalipsky ,  Durgadas Bolikal ,  Aruna Nathan ,  Joachim B. Kohn

IPC: A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61L15/26 ,  A61L27/18 ,  C08G63/685 ,  C08G65/32 ,  C08G69/10 ,  C08G69/40 ,  C08G69/44 ,  C08G81/00 ,  H01M6/18 ,  A61K31/74 ,  A61K31/765 ,  A61K31/785

CPC classification number: A61K47/48315 ,  A61K47/48215 ,  A61L15/26 ,  A61L27/18 ,  C08G63/6854 ,  C08G81/00 ,  Y10S530/81

Abstract: Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.

Abstract translation: 公开了聚（环氧烷）和氨基酸或肽序列的共聚物，其中氨基酸或肽序列具有侧链官能团，其能够与用于药物递送系统的药学活性化合物缀合并交联以形成作为 水凝胶膜。 共聚物也可以形成导电材料。 还公开了制备聚合物并形成药物共轭物，水凝胶膜和导电材料的方法。

公开(公告)号：US5317077A

公开(公告)日：1994-05-31

申请号：US39929

申请日：1993-03-29

Applicant: Joachim B. Kohn ,  James J. Fiordeliso

Inventor： Joachim B. Kohn ,  James J. Fiordeliso

IPC: A61K9/20 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22 ,  C08G63/685 ,  C08G64/12 ,  C08G69/44 ,  C08G63/00 ,  C08G63/06

CPC classification number: A61K9/204 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22 ,  C08G63/6854 ,  C08G64/12 ,  C08G69/44

Abstract: Bioerodible polyarylates derived from biocompatible dicarboxylic acids and natural amino acid-derived diphenol starting materials. Molded articles and controlled drug delivery systems prepared from the polyarylates are also disclosed.

Abstract translation: 衍生自生物相容性二羧酸和天然氨基酸衍生的二酚起始原料的生物可降解聚芳酯。 还公开了由多芳基化合物制备的成型制品和受控药物递送系统。

公开(公告)号：US5219564A

公开(公告)日：1993-06-15

申请号：US726301

申请日：1991-07-05

Applicant: Samuel Zalipsky ,  Durgadas Bolikal ,  Aruna Nathan ,  Joachim B. Kohn

Inventor： Samuel Zalipsky ,  Durgadas Bolikal ,  Aruna Nathan ,  Joachim B. Kohn

IPC: A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61L15/26 ,  A61L27/18 ,  C08G63/685 ,  C08G65/32 ,  C08G69/10 ,  C08G69/40 ,  C08G69/44 ,  C08G81/00 ,  H01M6/18

CPC classification number: A61K47/48315 ,  A61K47/48215 ,  A61L15/26 ,  A61L27/18 ,  C08G63/6854 ,  C08G81/00 ,  Y10S530/81

Abstract: Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.

Abstract translation: 公开了聚（环氧烷）和氨基酸或肽序列的共聚物，其中氨基酸或肽序列具有侧链官能团，其能够与用于药物递送系统的药物活性化合物缀合并交联以形成作为 水凝胶膜。 共聚物也可以形成导电材料。 还公开了制备聚合物并形成药物共轭物，水凝胶膜和导电材料的方法。

公开(公告)号：US5216115A

公开(公告)日：1993-06-01

申请号：US930146

申请日：1992-08-13

Applicant: Joachim B. Kohn ,  James J. Fiordeliso

Inventor： Joachim B. Kohn ,  James J. Fiordeliso

IPC: A61K47/34 ,  A61K9/20 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C271/18 ,  C07C271/22 ,  C08G63/685 ,  C08G63/78 ,  C08G64/12 ,  C08G69/44 ,  C08L101/16

CPC classification number: C08G64/12 ,  A61K9/204 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22 ,  C08G63/6854 ,  C08G69/44

Abstract: Bioerodible polyarylates derived from biocompatible dicarboxylic acids and natural amino acid-derived diphenol starting materials. Molded articles and controlled drug delivery systems prepared from the polyarylates are also disclosed.

Abstract translation: 衍生自生物相容性二羧酸和天然氨基酸衍生的二酚起始原料的生物可降解聚芳酯。 还公开了由多芳基化合物制备的成型制品和受控药物递送系统。

公开(公告)号：US09605112B2

公开(公告)日：2017-03-28

申请号：US13501255

申请日：2010-10-11

Applicant: Joachim B. Kohn ,  Durgadas Bolikal

Inventor： Joachim B. Kohn ,  Durgadas Bolikal

IPC: C07C231/08 ,  C08G69/44 ,  A61L17/00 ,  A61L24/00 ,  A61L31/00 ,  C08G69/08 ,  A61L24/04 ,  A61L27/18 ,  A61L31/06

CPC classification number: C08G69/44 ,  A61L24/046 ,  A61L27/18 ,  A61L31/06 ,  C08G69/08

Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.

公开(公告)号：US09511147B2

公开(公告)日：2016-12-06

申请号：US14238605

申请日：2012-08-12

Applicant: Joachim B. Kohn ,  Carmine P. Iovine ,  Niraj Ramachandran

Inventor： Joachim B. Kohn ,  Carmine P. Iovine ,  Niraj Ramachandran

IPC: A61K9/70 ,  A61L31/16 ,  A61K33/18 ,  A61K47/36 ,  A61K45/06 ,  A61K47/32 ,  A61L31/04 ,  C08G18/83

CPC classification number: A61K47/36 ,  A61K9/7023 ,  A61K33/18 ,  A61K45/06 ,  A61K47/32 ,  A61L31/042 ,  A61L31/048 ,  A61L31/16 ,  C08G18/831

Abstract: This invention relates to compositions and applications for an mterpolymer network delivery system containing iodine.

Abstract translation: 本发明涉及包含碘的聚合物网络递送系统的组合物和应用。

公开(公告)号：US08961948B2

公开(公告)日：2015-02-24

申请号：US13352268

申请日：2012-01-17

Applicant: Jared S. Bushman ,  Jenny E. Raynor ,  Joachim B. Kohn

Inventor： Jared S. Bushman ,  Jenny E. Raynor ,  Joachim B. Kohn

IPC: A61K31/74 ,  C08G63/685 ,  C08G63/64 ,  C08G63/91 ,  C08G64/12 ,  C08G64/18 ,  C08G64/42 ,  C08G69/40 ,  C08G69/44

CPC classification number: C08G63/6856 ,  C08G63/64 ,  C08G63/916 ,  C08G64/12 ,  C08G64/183 ,  C08G64/42 ,  C08G69/40 ,  C08G69/44

Abstract: Methods for constructing tyrosine-derived biotinylated polymers. Biotinylated polymers and polymer scaffolds constructed with the biotinylated polymers are also disclosed.

Abstract translation: 构建酪氨酸衍生的生物素化聚合物的方法。 还公开了用生物素化聚合物构建的生物素化聚合物和聚合物支架。

公开(公告)号：US08765161B2

公开(公告)日：2014-07-01

申请号：US13387908

申请日：2010-07-31

Applicant: Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

Inventor： Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

IPC: A61K47/34 ,  C08G67/00 ,  C08G79/02 ,  A61K47/48

CPC classification number: C08G79/02 ,  A61K47/59 ,  A61K47/60 ,  C08G79/025

Abstract: The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure.

Abstract translation: 本发明涉及可用于制备相分离的生物相容性聚合物或聚合物组合物的式（I）的新型单体。 这些聚合物或聚合物组合物可以是生物可再吸收的和/或可生物降解的并且具有期望的机械性能，例如断裂和/或疲劳韧性，其先前尚未成为这种聚合物的主要设计标准。 聚合物或聚合物组合物可用于各种医疗应用，例如在医疗装置的制造中。 因此，本公开也包括制备这些聚合物或聚合物组合物和医疗装置的方法。

公开(公告)号：US20110269848A1

公开(公告)日：2011-11-03

申请号：US13183051

申请日：2011-07-14

Applicant: Joachim B. Kohn ,  Durgadas Bolikal ,  Jaap Schut ,  Ernest G. Baluca

Inventor： Joachim B. Kohn ,  Durgadas Bolikal ,  Jaap Schut ,  Ernest G. Baluca

IPC: A61K47/30 ,  C08G69/40 ,  C08G69/42 ,  C08G65/48 ,  C07C69/96 ,  C08G64/16 ,  C07C229/34 ,  C07C321/16 ,  C07C211/45 ,  C08G69/00 ,  C08G65/333

CPC classification number: A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/6856 ,  C08G64/045 ,  C08G64/12 ,  C08G64/183 ,  C08G64/186 ,  C08G79/04 ,  C08L85/02 ,  C08L69/00

Abstract: Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.

Abstract translation: 包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效， 与没有N-取代的相同聚合物相比。