公开(公告)号：US07989490B2

公开(公告)日：2011-08-02

申请号：US10858954

申请日：2004-06-02

Applicant: Robert Falotico ,  Jonathon Z. Zhao

Inventor： Robert Falotico ,  Jonathon Z. Zhao

IPC: A61K31/337

CPC classification number: A61K9/0019 ,  A61K9/19 ,  A61K31/337 ,  A61K47/22

Abstract: Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered for the treatment of vascular disease. In each of these instances, antioxidants are utilized to prolong product integrity.

Abstract translation: 液体制剂，包括各种药物，试剂和/或化合物的溶液和悬浮液，可局部或区域输送用于治疗血管疾病。 在每种情况下，使用抗氧化剂来延长产品的完整性。

公开(公告)号：US07939095B2

公开(公告)日：2011-05-10

申请号：US11614395

申请日：2006-12-21

Applicant: Jonathon Z. Zhao

Inventor： Jonathon Z. Zhao

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/10 ,  A61L31/12 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  C08J7/047 ,  C08J2467/00 ,  C08J2483/00 ,  C09D4/00 ,  C09D167/04 ,  Y10T29/49984 ,  Y10T428/31511 ,  Y10T428/31525 ,  Y10T428/31529 ,  Y10T428/31663 ,  C08L67/04 ,  C08L83/04 ,  C08G77/28

Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a combination ofsilane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.

Abstract translation: 提供涂层，其中可以通过将硅烷衍生物（A）的组合与金属表面共价键合来活化，通过原位开环聚合将内酯聚合物（B）共价结合到硅烷衍生物上，并沉积至少一层 粘合内酯聚合物上的聚酯（C）。 生物活性剂或治疗化合物可以沉积任何聚酯层。 这种涂覆的表面可用于医疗装置，特别是支架。

公开(公告)号：US07932265B2

公开(公告)日：2011-04-26

申请号：US12908949

申请日：2010-10-21

Applicant: Robert Falotico ,  Jonathon Z. Zhao

Inventor： Robert Falotico ,  Jonathon Z. Zhao

IPC: A61K31/44

CPC classification number: A61L31/16 ,  A61K9/0019 ,  A61K31/436 ,  A61K31/4745 ,  A61K47/10 ,  A61K47/22 ,  A61L2300/416

Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

Abstract translation: 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 治疗剂也可以递送到疾病部位的区域。 在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US20110029070A1

公开(公告)日：2011-02-03

申请号：US12906295

申请日：2010-10-18

Applicant: Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

Inventor： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

IPC: A61F2/82 ,  B05D7/00

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2250/0043 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16

Abstract: An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.

Abstract translation: 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

公开(公告)号：US07846940B2

公开(公告)日：2010-12-07

申请号：US10813965

申请日：2004-03-31

Applicant: Robert Falotico ,  Jonathon Z. Zhao

Inventor： Robert Falotico ,  Jonathon Z. Zhao

IPC: A61K31/44

CPC classification number: A61L31/16 ,  A61K9/0019 ,  A61K31/436 ,  A61K31/4745 ,  A61K47/10 ,  A61K47/22 ,  A61L2300/416

Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

Abstract translation: 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 治疗剂也可以递送到疾病部位的区域。 在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US20100280600A1

公开(公告)日：2010-11-04

申请号：US12433082

申请日：2009-04-30

Applicant: Vipul Bhupendra Dave ,  Robert Falotico ,  Chengxue li ,  Thai Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

Inventor： Vipul Bhupendra Dave ,  Robert Falotico ,  Chengxue li ,  Thai Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

IPC: A61F2/82

CPC classification number: A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/434 ,  A61L2300/45

Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue and/or the bloodstream.

Abstract translation: 可植入的医疗装置可用于局部递送一种或多种药物或治疗剂以治疗各种各样的病症，包括治疗生物体对引入可植入医疗装置的反应。 这些治疗剂可以在控制和定向条件下释放，使得一种或多种治疗剂达到正确的靶区域，例如周围组织和/或血流。

公开(公告)号：US07806924B2

公开(公告)日：2010-10-05

申请号：US10780596

申请日：2004-02-18

Applicant: Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

Inventor： Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2420/08 ,  C08L33/02 ,  C08L27/12

Abstract: Medical devices, and in particular implantable structures, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization.

Abstract translation: 可以涂覆医疗装置，特别是可植入结构，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。

公开(公告)号：US07771705B2

公开(公告)日：2010-08-10

申请号：US12412052

申请日：2009-03-26

Applicant: Jonathon Z. Zhao

Inventor： Jonathon Z. Zhao

IPC: A61K49/00 ,  A61K49/04

CPC classification number: A61K49/0438 ,  A61K49/0442 ,  A61L17/06 ,  A61L17/145 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/18 ,  C07H13/08 ,  C07H17/02

Abstract: The present invention discloses a radiographic contrasting agent containing multiple aromatic groups, each of which is substituted with at least three halogen atoms. The radiographic contrasting agent can initiate a polymerization process. The present invention also discloses a radio-opaque polymeric material that comprises a biodegradable polymer having at least one radiographic contrasting moiety covalently attached thereto. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.

Abstract translation: 本发明公开了含有多个芳族基团的放射线造影剂，每个芳族基团被至少三个卤素原子取代。 射线照相对比剂可以引发聚合过程。 本发明还公开了一种不透射线的聚合物材料，其包括具有共价连接到其上的至少一个放射照相对照部分的可生物降解的聚合物。 射线不透明聚合物材料在放射照相成像中提供增强的对比强度。 不透射线的聚合材料可以施加在医疗装置的一个表面的至少一部分上。 不透射线的聚合物材料也可用于构建医疗器械，其部件或其部件的一部分。

公开(公告)号：US20100152841A1

公开(公告)日：2010-06-17

申请号：US12335741

申请日：2008-12-16

Applicant: Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

Inventor： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2250/0043 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16

Abstract: An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.

Abstract translation: 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

公开(公告)号：US20100131050A1

公开(公告)日：2010-05-27

申请号：US12277556

申请日：2008-11-25

Applicant: Jonathon Z. Zhao

Inventor： Jonathon Z. Zhao

IPC: A61F2/82

CPC classification number: A61F2/89 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2420/00 ,  C08L67/04

Abstract: A biocompatible metallic material may be configured into any number of implantable medical devices, including intraluminal stents. The biocompatible metallic material may comprise a magnesium alloy. The magnesium alloy implantable medical device may be designed to degrade over a given period of time. In order to control the degradation time, the device may be coated or otherwise have affixed thereto one or more coatings, one of which comprises a material for controlling the degradation time and maintain a pH neutral environment proximate the device. Additionally, therapeutic agents may be incorporated into one or more of the coatings on the implantable medical device.

Abstract translation: 生物相容性金属材料可以被配置成任何数量的可植入医疗装置，包括腔内支架。 生物相容性金属材料可以包括镁合金。 镁合金可植入医疗装置可以设计成在给定的时间段内降解。 为了控制降解时间，可以将该装置涂覆或以其它方式固定到其上一个或多个涂层，其中一个涂层包括用于控制降解时间的材料，并且在该装置附近保持pH中性环境。 此外，治疗剂可以并入到可植入医疗装置上的一个或多个涂层中。