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公开(公告)号：US08887477B2
公开(公告)日：2014-11-18
申请号：US12619118
申请日：2009-11-16
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.
摘要翻译： 本发明提供了一种用于生物活性肝素涂层在包含用于医疗装置例如导管，组织工程支架或药物递送载体材料中的肝素的材料和生物材料上的单步末端灭菌方法。 这可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的任何医疗装置或植入物。 其它相关装置实例可包括肝素或肝素衍生物涂层支架以减少凝血和再狭窄，牙科或眼科植入物。 这些材料可以包含另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。 这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生的材料的医疗装置的其它基底上。
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公开(公告)号：US20110029070A1
公开(公告)日：2011-02-03
申请号：US12906295
申请日：2010-10-18
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。
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公开(公告)号：US20100152841A1
公开(公告)日：2010-06-17
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。
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公开(公告)号：US07444560B2
公开(公告)日：2008-10-28
申请号：US10975315
申请日：2004-10-28
申请人： Thai M. Nguyen , William Shen , Cam Lu
发明人： Thai M. Nguyen , William Shen , Cam Lu
CPC分类号： G01R31/31725 , G01R31/31721 , G01R31/318575 , G01R31/318594 , G11C29/12015 , G11C29/14
摘要： A test clocking scheme that separates the clock driving the functional logic and the memory from the clock driving the test logic and the memory. In other words, the test clocking scheme separates the memory functional clock from the memory test clock into two clock paths. The test clocking scheme provides for the ability to separately shut off either the memory functional clock source or the memory test clock source, provides that less power is required during production testing, and provides that simulation time is reduced during design verification because the functional logic is not clocked.
摘要翻译： 测试时钟方案，将驱动功能逻辑和存储器的时钟与驱动测试逻辑和存储器的时钟进行分离。 换句话说，测试时钟方案将存储器功能时钟与存储器测试时钟分离成两个时钟路径。 测试时钟方案提供分开关闭存储器功能时钟源或存储器测试时钟源的能力，提供在生产测试期间需要较少的功率，并且提供在设计验证期间减少仿真时间，因为功能逻辑是 没时钟
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公开(公告)号：US06172566B2
公开(公告)日：2001-01-09
申请号：US09251698
申请日：1999-02-17
申请人： Thai M. Nguyen
发明人： Thai M. Nguyen
IPC分类号： H03F345
CPC分类号： H03G1/0023 , H03F1/22 , H03F3/72 , H03F2200/294 , H03F2200/372 , H03F2203/7221 , H03G1/0088
摘要： A low noise amplifier circuit is operable in two gain modes: high gain (approximately 15 dB) and low gain or attenuation (approximately −5 dB), with a number of gain paths. In the low gain or attenuation path, the frequency response is improved by adding a diode-connected transistor and a capacitor connected in series and operating as a filter, which effectively puts a pole (p=−1/RL Ct) in the peak of the high frequency response.
摘要翻译： 低噪声放大器电路可以以两种增益模式工作：高增益（约15dB）和低增益或衰减（约-5dB），具有多个增益路径。 在低增益或衰减路径中，通过添加二极管连接的晶体管和串联连接的电容器作为滤波器来增加频率响应，有效地将极点（p = -1 / RL Ct）置于峰值 高频响应。
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公开(公告)号：US5214317A
公开(公告)日：1993-05-25
申请号：US878134
申请日：1992-05-04
申请人： Thai M. Nguyen
发明人： Thai M. Nguyen
IPC分类号： H03K3/037 , H03K3/2885 , H03K3/356 , H03K19/0175
CPC分类号： H03K3/2885 , H03K3/356034
摘要： An electrical circuit is disclosed which implements a CMOS to ECL translator with an incorporated latch. The invention provides a circuit which uses a small number of devices, and provides fast transition times with low power consumption.
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公开(公告)号：US20110113728A1
公开(公告)日：2011-05-19
申请号：US12619118
申请日：2009-11-16
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.
摘要翻译： 本发明提供了一种用于生物活性肝素涂层在包含用于医疗装置例如导管，组织工程支架或药物递送载体材料中的肝素的材料和生物材料上的单步末端灭菌方法。 这可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的任何医疗装置或植入物。 其它相关装置实例可包括肝素或肝素衍生物涂层支架以减少凝血和再狭窄，牙科或眼科植入物。 这些材料可以包含另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。 这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生的材料的医疗装置的其它基底上。
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公开(公告)号：US07819914B2
公开(公告)日：2010-10-26
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。
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公开(公告)号：US5917349A
公开(公告)日：1999-06-29
申请号：US947780
申请日：1997-10-09
申请人： Thai M. Nguyen
发明人： Thai M. Nguyen
CPC分类号： H03F3/45085 , H03F3/50 , H03F2203/45648 , H03F2203/45722
摘要： An improved current mode driver circuit uses N-type transistors in current mirrors to achieve higher speed operation at lower cost. A pair of matched low frequency P-type transistors provide a small amount of current to each side of the differential amplifier which comprise of only N-type transistors in a current mirror connection to amplify the current supplied thereto.
摘要翻译： 改进的电流模式驱动电路使用电流镜中的N型晶体管以更低的成本实现更高速度的运行。 一对匹配的低频P型晶体管在差分放大器的每一侧提供少量的电流，该电流仅包括电流镜连接中的N型晶体管，以放大提供给它的电流。
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公开(公告)号：US20100161039A1
公开(公告)日：2010-06-24
申请号：US12342465
申请日：2008-12-23
申请人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
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