公开(公告)号：US08927049B2

公开(公告)日：2015-01-06

申请号：US12854463

申请日：2010-08-11

申请人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

发明人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

IPC分类号： A61F2/06 ,  A61L33/00 ,  B05D3/00 ,  B05D1/32 ,  A61L31/16 ,  A61F2/91 ,  A61L31/10

CPC分类号： A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/00

摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.

摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

公开(公告)号：US20110245332A1

公开(公告)日：2011-10-06

申请号：US13158610

申请日：2011-06-13

申请人： Robert Falotico ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Jonathon Z. Zhao

IPC分类号： A61K31/337 ,  A61P9/00

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K31/337 ,  A61K47/22

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered. In each of these instances, antioxidants are utilized to prolong product integrity.

公开(公告)号：US20100304007A1

公开(公告)日：2010-12-02

申请号：US12854463

申请日：2010-08-11

申请人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

发明人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

IPC分类号： A61L33/00

CPC分类号： A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/00

摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.

摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

公开(公告)号：US20090311299A1

公开(公告)日：2009-12-17

申请号：US12334849

申请日：2008-12-15

申请人： Robert Falotico ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Jonathon Z. Zhao

IPC分类号： A61F2/06 ,  A61K47/32

CPC分类号： A61L33/0029 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

公开(公告)号：US20090281059A1

公开(公告)日：2009-11-12

申请号：US12505869

申请日：2009-07-20

申请人： Robert Falotico ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Jonathon Z. Zhao

IPC分类号： A61K31/727 ,  A61P7/02 ,  C08F251/00

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L33/0029 ,  C08L67/04

摘要： A conjugate between an anti-thrombotic agent and bioabsorbable polymer is provided. Also, a method is provided for applying a coating comprising an anti-thrombotic agent and bioabsorbable polymer conjugate to at least some of an implantable device to prevent or reduce formation of thrombosis on the surface of the device. A first or sub-layer of the coating is prepared by mixing polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprises an anti-thrombotic heparin-bioabsorbable polymer conjugate. This coating may be applied over inner drug-containing layers using, for example, dip coating or spray coating processes. After drying, the anti-thrombotic heparin bioabsorbable polymer conjugate remains in the outer layer of coating, allowing agent from the inner layer to elute there through. Also, the outmost layer prevents thrombosis, and can modulate release kinetics of agent(s) contained within inner layer(s) of the coating.

摘要翻译： 提供抗血栓形成剂和生物可吸收聚合物之间的缀合物。 而且，提供了一种方法，其用于将包含抗血栓形成剂和生物可吸收聚合物缀合物的涂层施用于至少一些可植入装置，以防止或减少装置表面上的血栓形成。 通过将聚合材料和生物活性剂与溶剂混合制备涂层的第一层或次层，从而形成均匀溶液。 第二层或外层包含抗血栓形成肝素 - 生物可吸收聚合物缀合物。 可以使用例如浸涂或喷涂方法将该涂层施加在内含药物层上。 干燥后，抗血栓形成的肝素生物可吸收聚合物缀合物保留在涂层的外层，允许来自内层的药剂在那里洗脱。 此外，最外层可防止血栓形成，并且可以调节包被在内层内的药剂的释放动力学。

公开(公告)号：US20080026034A1

公开(公告)日：2008-01-31

申请号：US11493324

申请日：2006-07-26

申请人： David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

发明人： David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

IPC分类号： A61F2/02 ,  A61K31/4745

CPC分类号： A61L31/10 ,  A61F2/07 ,  A61F2/91 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/075 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Implantable coated medical devices may be processed through annealing to better control the elution characteristics of the therapeutic agents. Furthermore, annealing leads to better therapeutic agent stability and a larger device shelf-life.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。 药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。 可以通过退火处理可植入的涂覆的医疗装置，以更好地控制治疗剂的洗脱特性。 此外，退火导致更好的治疗剂稳定性和更大的器件保质期。

公开(公告)号：US07303758B2

公开(公告)日：2007-12-04

申请号：US10761032

申请日：2004-01-20

申请人： Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

IPC分类号： A61F2/00 ,  A61F2/06

CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/21 ,  A61L2300/416 ,  A61L2420/08 ,  C08L27/16 ,  C08L27/20

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US07947302B2

公开(公告)日：2011-05-24

申请号：US12334849

申请日：2008-12-15

申请人： Robert Falotico ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Jonathon Z. Zhao

IPC分类号： A61F2/06 ,  A61K47/32

CPC分类号： A61L33/0029 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

公开(公告)号：US07695731B2

公开(公告)日：2010-04-13

申请号：US10805722

申请日：2004-03-22

申请人： Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

发明人： Robert Falotico ,  Tom Jay Parry ,  Jonathon Z. Zhao

IPC分类号： A61F2/06

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/608 ,  A61L2420/08

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US20090074831A1

公开(公告)日：2009-03-19

申请号：US11857285

申请日：2007-09-18

申请人： Robert Falotico ,  Andrew Sheung-King Luk ,  Theodore L. Parker ,  Jonathon Z. Zhao ,  Lei Zhao

发明人： Robert Falotico ,  Andrew Sheung-King Luk ,  Theodore L. Parker ,  Jonathon Z. Zhao ,  Lei Zhao

IPC分类号： A61K9/00 ,  A61K31/427 ,  A61K31/4439

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/432 ,  A61L2300/45 ,  A61L2300/602

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。 药物，药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病，包括易损斑块和动脉粥样硬化。 治疗剂也可以递送到疾病部位的区域。 在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药剂或化合物维持在医疗装置上，直到被输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。