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    LOCAL VASCULAR DELIVERY OF ADENOSINE A2A RECEPTOR AGONISTS TO REDUCE MYOCARDIAL INJURY
    3.
    发明申请
    LOCAL VASCULAR DELIVERY OF ADENOSINE A2A RECEPTOR AGONISTS TO REDUCE MYOCARDIAL INJURY 审中-公开
    腺苷A2A受体激动剂局部血管输送减少心肌损伤

    公开(公告)号：US20120130480A1

    公开(公告)日：2012-05-24

    申请号：US12971037

    申请日：2010-12-17

    申请人： Robert Falotico ,  Theodore L. Parker

    发明人： Robert Falotico ,  Theodore L. Parker

    IPC分类号： A61F2/82

    CPC分类号： A61L31/06 ,  A61K31/436 ,  A61K31/7076 ,  A61K31/727 ,  A61L31/16 ,  C08L67/04

    摘要： A stent or other implantable medical device for the local delivery of a selective adenosine receptor agonist may be utilized to reduce myocardial injury following an acute myocardial infarction. As soon as possible following an acute myocardial infarction a stent or other suitable device comprising and capable of delivering a selective adenosine receptor agonist is positioned in the blood vessel with the occlusion responsible for causing the infarct. Once in position , the stent or other intraluminal device is deployed to remove the occlusion and reestablish blood flow to the specific area, region or tissue volume of the heart. Over a given period of time the selective adenosine receptor agonist elutes from the stent or other device into the downstream coronary blood flow into the hypoxic cardiac tissue for a time sufficient to reduce the level of myocardial injury.

    摘要翻译： 用于局部递送选择性腺苷受体激动剂的支架或其它可植入医疗装置可用于减少急性心肌梗塞后的心肌损伤。 在急性心肌梗死后，尽快地将包含能够递送选择性腺苷受体激动剂的支架或其它合适的装置置于血管中，其中负责引起梗死的闭塞。 一旦就位，支架或其他管腔内装置被部署以去除闭塞并重新建立血液流到心脏的特定区域，区域或组织体积。 在给定的时间段内，选择性腺苷受体激动剂从支架或其他装置洗脱到进入缺氧心脏组织的下游冠状动脉血液中足以降低心肌损伤水平的时间。

    E BEAM STERILIZATION OF MEDICAL DEVICES COMPRISING BIOACTIVE COATING
    4.
    发明申请
    E BEAM STERILIZATION OF MEDICAL DEVICES COMPRISING BIOACTIVE COATING 有权
    E包含生物涂料的医疗装置的束灭菌

    公开(公告)号：US20110113728A1

    公开(公告)日：2011-05-19

    申请号：US12619118

    申请日：2009-11-16

    申请人： Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

    发明人： Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

    IPC分类号： B65B55/08 ,  B65B31/04

    CPC分类号： B65B31/00 ,  A61L2/087 ,  A61L2202/21 ,  B65B55/00 ,  B65B55/16 ,  B65D81/266

    摘要： The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.

    摘要翻译： 本发明提供了一种用于生物活性肝素涂层在包含用于医疗装置例如导管，组织工程支架或药物递送载体材料中的肝素的材料和生物材料上的单步末端灭菌方法。 这可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的任何医疗装置或植入物。 其它相关装置实例可包括肝素或肝素衍生物涂层支架以减少凝血和再狭窄，牙科或眼科植入物。 这些材料可以包含另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。 这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生的材料的医疗装置的其它基底上。

    Adhesion promoting primer for coated surfaces
    5.
    发明授权
    Adhesion promoting primer for coated surfaces 有权
    涂层表面的粘合促进底漆

    公开(公告)号：US07819914B2

    公开(公告)日：2010-10-26

    申请号：US12335741

    申请日：2008-12-16

    申请人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

    发明人： Vipul Dave ,  Robert Falotico ,  Chengxue Li ,  Thai M. Nguyen ,  Theodore L. Parker ,  Jonathon Z. Zhao

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2250/0043 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16

    摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.

    摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。 多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。 为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的药剂也可用于解决来自同一药物递送装置的不同疾病。 此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。 为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

    Strippable coating for optical fiber
    9.
    发明授权
    Strippable coating for optical fiber 失效
    光纤剥离涂层

    公开(公告)号：US5373578A

    公开(公告)日：1994-12-13

    申请号：US170885

    申请日：1993-12-21

    申请人： Theodore L. Parker ,  James R. Petisce ,  Lloyd Shepherd ,  Carl R. Taylor

    发明人： Theodore L. Parker ,  James R. Petisce ,  Lloyd Shepherd ,  Carl R. Taylor

    IPC分类号： C03C25/10 ,  C03C25/24 ,  G02B6/245 ,  G02B6/44 ,  G02B6/22

    CPC分类号： G02B6/4403 ,  C03C25/106 ,  C03C25/1065 ,  G02B6/245 ,  G02B6/443 ,  Y10T428/2933 ,  Y10T428/2964

    摘要： A coating system for individual glass fibers of a lightwave communications system has improved strippability, particularly in situations where a group of such fibers are arrayed together in what is known as a ribbon. A preferred embodiment includes two layers (primary and secondary) of polymeric materials surrounding the glass fiber. The primary layer comprises an oligomer (50-80% by weight), a diluent (15-40% by weight), and additives (5-35% by weight). The oligomer comprises polyol "A," diisocyanate "B," and a hydroxy-terminated alkyl acrylate "C" having the structure C-B-A-B-C. At least one of the additives contains a non-crosslinked hydrocarbon component (1-20% by weight) having a structure R.sub.1 --(R).sub.n --R.sub.2 ; where R.sub.1, R.sub.2 comprises an alkyl group or an OH group, and R is a combination of C, H or C, H, O. In an alternative embodiment, the need for a diluent is substantially eliminated by using an oligomer having the structure E-D-E where "D" represents a carboxy-terminated polyol, and "E" represents a glycidyl acrylate.

    摘要翻译： 用于光波通信系统的单个玻璃纤维的涂覆系统具有改善的剥离性，特别是在将一组这种纤维以所谓的带状排列在一起的情况下。 优选的实施方案包括围绕玻璃纤维的聚合材料的两层（初级和次级）。 主层包含低聚物（50-80重量％），稀释剂（15-40重量％）和添加剂（5-35重量％）。 低聚物包含多元醇“A”，二异氰酸酯“B”和具有结构C-B-A-B-C的羟基封端的丙烯酸烷基酯“C”。 至少一种添加剂含有具有结构R1-（R）n-R2的非交联烃组分（1-20重量％）; 其中R1，R2包含烷基或OH基团，R是C，H或C，H，O的组合。在一个替代实施方案中，通过使用具有结构EDE的低聚物，基本上消除了稀释剂的需要 其中“D”表示羧基封端的多元醇，“E”表示丙烯酸缩水甘油酯。

    Curing polyester or polycarbonate and polyepoxide with polyorgano phosphorous catalyst
    10.
    发明授权
    Curing polyester or polycarbonate and polyepoxide with polyorgano phosphorous catalyst 失效
    用聚有机磷催化剂固化聚酯或聚碳酸酯和聚环氧化物

    公开(公告)号：US5182344A

    公开(公告)日：1993-01-26

    申请号：US690147

    申请日：1991-04-23

    申请人： Theodore L. Parker

    发明人： Theodore L. Parker

    IPC分类号： C08G59/68 ,  C08L63/00 ,  C08L67/02 ,  C08L69/00

    CPC分类号： C08L63/00 ,  C08G59/688 ,  C08L67/02 ,  C08L69/00

    摘要： Thermoformable, thermosettable resins essentially free of secondary alcohol groups are obtained by reaction of oxiranes in active hydrogen-free polyepoxide with carboxylate and/or carbonate groups in active hydrogen-free aryl polyesters, polycarbonates or copolyestercarbonates in the presence of catalytically effective amounts of certain polyorgano phosphonium or phosphine iminium salts.

    摘要翻译： 通过在无活性氢的聚环氧化物中的环氧乙烷与活性无氢芳基聚酯，聚碳酸酯或共聚酯碳酸酯中的羧酸酯和/或碳酸酯基团在催化有效量的某些聚有机物存在下反应，可获得基本上不含仲醇基团的可热成型热固性树脂 鏻或膦亚胺盐。