Abstract:
A circuit for sensing load current of a voltage regulator. The circuit includes a power transistor and a minor transistor. A first transistor sizing circuit is coupled to the power transistor and is operable to control size of the power transistor based on a bias voltage of the power transistor, thereby regulating a first voltage for varying load conditions. The circuit also includes a feedback amplifier coupled to the power transistor and the mirror transistor. A transistor is coupled to the feedback amplifier and the mirror transistor. An analog to digital converter (ADC) is coupled to the transistor. A second transistor sizing circuit is coupled to the mirror transistor, the transistor, and the ADC. The second transistor sizing circuit is responsive to an output voltage to control size of the minor transistor, thereby ensuring that accuracy of output voltage sensed by ADC is not limited by ADC's resolution.
Abstract:
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Abstract:
In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue.
Abstract:
A system and method for automatically upgrading/reverting of the software configurations in a storage system environment among a plurality of product release lines. A configuration upgrade/revert module of a storage system management module identifies a shortest path between an initial configuration and a desired end configuration using a transition table comprising of a plurality of transition functions. The upgrade/revert configuration module invokes the appropriate series of transition functions to modify the software configuration from the initial state to the desired end state.
Abstract:
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
Abstract:
The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
Abstract:
An embodiment of a network manager permits a resource group administrator (with resource group level permissions but without global permissions) to add a global object to his/her resource group as a managed object, without requiring the administrator to have a global permission, as discussed further below. An embodiment of the network manager permits a resource group administrator to also edit the configuration settings that are attached to his/her resource group without requiring the administrator to have a global permission.
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.