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72 条记录 (耗时 0.027 秒)

    Method of using p-acylaminophenoxycarbamates and derivatives as analgesics
    61.
    发明授权
    Method of using p-acylaminophenoxycarbamates and derivatives as analgesics 失效
    使用对氨基苯氧基氨基甲酸酯和衍生物作为止痛剂的方法

    公开(公告)号：US5214061A

    公开(公告)日：1993-05-25

    申请号：US837190

    申请日：1992-02-18

    申请人： Richard C. Allen ,  Raymond W. Kosley, Jr. ,  Bettina Spahl

    发明人： Richard C. Allen ,  Raymond W. Kosley, Jr. ,  Bettina Spahl

    IPC分类号： C07C271/40 ,  C07C271/44 ,  C07D213/54 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07C271/40 ,  C07C271/44 ,  C07D213/54 ,  C07D233/56 ,  C07D249/08

    摘要： This invention relates to p-acylaminophenoxycarbamates having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl and arylloweralkyl; R.sub.3 is hydrogen, loweralkyl, arylloweralkyl; R.sub.4 is hydrogen, loweralkyl, formyl, alkylcarbonyl, arylloweralkyl, phenylcarbonyl, arylloweralkylcarbonyl, substituted phenylcarbonyl, pyridylcarbonyl, and substituted pyridylcarbonyl with the proviso that if R.sub.4 contains a carbonyl group directly attached to the oxygen of the N-O moiety, R.sub.3 cannot be hydrogen; or R.sub.3 and R.sub.4 taken together from a heterocyclic ring selected from the group consisting of imidazole or loweralkylimidazole; X is hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; and p is an integer selected from 0 and 1; the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics.

    摘要翻译： 本发明涉及具有式“IMAGE”的对酰氨基苯氧基氨基甲酸酯，其中R 1和R 2各自独立地为氢，低级烷基，芳基和芳基低级烷基; R3是氢，低级烷基，芳基低级烷基; R4是氢，低级烷基，甲酰基，烷基羰基，芳基低级烷基，苯基羰基，芳基低级烷基羰基，取代的苯基羰基，吡啶基羰基和取代的吡啶基羰基，条件是如果R4含有直接键合在N-O部分的氧上的羰基，则R3不能是氢; 或者R 3和R 4一起选自咪唑或低级烷基咪唑的杂环; X是氢，卤素，羟基，低级烷基，低级烷氧基，硝基，氨基或三氟甲基; 并且p是选自0和1的整数; 其药学上可接受的酸加成盐，以及适用的几何和立体异构体及其外消旋混合物。 本发明化合物显示出作为止痛剂的效用。

    Intermediates for spiro[2H-1,4 benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds
    68.
    发明授权
    Intermediates for spiro[2H-1,4 benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds 失效
    螺[2H-1,4苯并二氧杂环庚烯-3（5H）4'-哌啶和-3'-吡咯烷]化合物的中间体

    公开(公告)号：US4695637A

    公开(公告)日：1987-09-22

    申请号：US811245

    申请日：1985-12-19

    申请人： Raymond W. Kosley, Jr. ,  Robert J. Cherill

    发明人： Raymond W. Kosley, Jr. ,  Robert J. Cherill

    IPC分类号： C07D211/48 ,  C07D491/10 ,  C07D409/04

    CPC分类号： C07D491/10 ,  C07D211/48

    摘要： Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

    摘要翻译： 具有本文定义的取代基的式[IMAGE]的螺[2H-1,4-苯并二氧杂环庚烷-3（5H）4'-哌啶和-3-吡咯烷]化合物可用于治疗哺乳动物的高血压。 提供这样的化合物，它们作为抗高血压药的用途，含有化合物的药物组合物，中间体和制备化合物的方法。

    Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'piperidine and -3'-pyrrolidine] compounds
    70.
    发明授权
    Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'piperidine and -3'-pyrrolidine] compounds 失效
    螺[2H-1,4-苯并二氧杂环庚烷-3（5H）4'-哌啶和-3'-吡咯烷]化合物的中间体

    公开(公告)号：US4668791A

    公开(公告)日：1987-05-26

    申请号：US765740

    申请日：1985-08-15

    申请人： Raymond W. Kosley, Jr. ,  Robert J. Cherill

    发明人： Raymond W. Kosley, Jr. ,  Robert J. Cherill

    IPC分类号： C07D211/48 ,  C07D491/10

    CPC分类号： C07D491/10 ,  C07D211/48

    摘要： Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.

    摘要翻译： 具有本文定义的取代基的式[IMAGE]的螺[2H-1,4-苯并二氧杂环庚烷-3（5H）4'-哌啶和-3-吡咯烷]化合物可用于治疗哺乳动物的高血压。 提供这样的化合物，它们作为抗高血压药的用途，含有化合物的药物组合物，中间体和制备化合物的方法。