公开(公告)号：US20090118197A1

公开(公告)日：2009-05-07

申请号：US12246229

申请日：2008-10-06

Applicant: Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

Inventor： Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

IPC: A61K38/08 ,  C07K7/06 ,  A61P29/00

CPC classification number: A61K38/08 ,  C07K7/06

Abstract: Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

Abstract translation: 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1刺激Akt磷酸化。

公开(公告)号：US07517857B2

公开(公告)日：2009-04-14

申请号：US11317924

申请日：2005-12-23

Applicant: Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

Inventor： Sung-Ho Ryu ,  Pann-Ghill Suh ,  Yoe-Sik Bae ,  Ji-Young Song

IPC: A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  C07K5/083 ,  C07K5/107 ,  C07K5/11 ,  C07K7/06

CPC classification number: A61K38/08 ,  C07K7/06

Abstract: Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

Abstract translation: 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1刺激Akt磷酸化。

公开(公告)号：US20080274978A1

公开(公告)日：2008-11-06

申请号：US10597591

申请日：2005-02-03

Applicant: Pann-Ghill Suh ,  Yoe-Sik Bae ,  Sung Ho Ryu ,  Tae Hoon Lee

Inventor： Pann-Ghill Suh ,  Yoe-Sik Bae ,  Sung Ho Ryu ,  Tae Hoon Lee

IPC: A61K38/00 ,  C07K7/00 ,  C12N5/06 ,  G01N33/53 ,  A61P25/00

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/0821 ,  C07K5/1019 ,  C07K5/1024 ,  Y10S514/825

Abstract: The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.

Abstract translation: 本申请公开了可用于抑制FPR类受体活性的富含W的肽。

公开(公告)号：US20070053923A1

公开(公告)日：2007-03-08

申请号：US10543999

申请日：2004-01-30

Applicant: Ki-Seok Park ,  Su-Hyung Park ,  Se-Hwan Yang ,  Chang-Geun Lee ,  So-Young Choi ,  Sung-Ho Ryu ,  Youn-Dong Kim

Inventor： Ki-Seok Park ,  Su-Hyung Park ,  Se-Hwan Yang ,  Chang-Geun Lee ,  So-Young Choi ,  Sung-Ho Ryu ,  Youn-Dong Kim

IPC: A61K48/00 ,  A61K39/21

CPC classification number: C07K14/005 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55516 ,  C12N2740/16022 ,  C12N2760/16022

Abstract: Disclosed is a vaccine composition that includes a peptide adjuvant, and a DNA vaccine encoding an immunogenic protein. Also, the present invention discloses a method of enhancing immune responses, which is based on the administration of the vaccine composition.

Abstract translation: 公开了包含肽佐剂和编码免疫原性蛋白质的DNA疫苗的疫苗组合物。 此外，本发明公开了一种增强免疫应答的方法，其基于疫苗组合物的施用。