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公开(公告)号：US20080274978A1
公开(公告)日：2008-11-06
申请号：US10597591
申请日：2005-02-03
申请人： Pann-Ghill Suh , Yoe-Sik Bae , Sung Ho Ryu , Tae Hoon Lee
发明人： Pann-Ghill Suh , Yoe-Sik Bae , Sung Ho Ryu , Tae Hoon Lee
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0821 , C07K5/1019 , C07K5/1024 , Y10S514/825
摘要： The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.
摘要翻译： 本申请公开了可用于抑制FPR类受体活性的富含W的肽。
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2.发明申请LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE 审中-公开调节免疫反应的配对及其在治疗免疫反应相关疾病中的应用公开(公告)号：US20100291089A1
公开(公告)日：2010-11-18
申请号：US11993655
申请日：2006-07-07
申请人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K39/395 , C07K14/435 , A61K38/08 , A61K39/10 , A61K31/5377 , A61K31/352 , A61K31/713 , A61P37/02 , A61P29/00 , A61P25/28 , A61P9/10 , A61P35/00
CPC分类号： A61K38/1796 , A61K38/08
摘要： The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA).
摘要翻译： 本发明涉及调节免疫应答的配体，即垂体腺苷酸环化酶活化多肽和血清淀粉样蛋白A（SAA）之一的PACAP27及其在治疗或预防与免疫应答有关的疾病中的新用途。 更具体地，本发明涉及具有对免疫应答的调节作用的PACAP27-FPRL1的复合物及其在调节免疫应答中的用途。 另一方面，本发明涉及SAA和FPRL1的复合物及其在抑制滑膜细胞增生和血管生成中的用途，并且治疗或预防包括类风湿性关节炎（RA）在内的炎性疾病。
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公开(公告)号：US07671028B2
公开(公告)日：2010-03-02
申请号：US10597591
申请日：2005-02-03
申请人： Pann-Ghill Suh , Yoe-Sik Bae , Sung Ho Ryu , Tae Hoon Lee , Ha Young Lee , Eun Jin Jo , Jung-Im Kim , Hyun-Kyu Kang , Richard D. Ye , Jong-Young Kwak
发明人： Pann-Ghill Suh , Yoe-Sik Bae , Sung Ho Ryu , Tae Hoon Lee , Ha Young Lee , Eun Jin Jo , Jung-Im Kim , Hyun-Kyu Kang , Richard D. Ye , Jong-Young Kwak
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0821 , C07K5/1019 , C07K5/1024 , Y10S514/825
摘要： The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.
摘要翻译： 本申请公开了可用于抑制FPR类受体活性的富含W的肽。
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公开(公告)号：US07390870B2
公开(公告)日：2008-06-24
申请号：US10186035
申请日：2002-06-28
申请人： Hyunjoo Bae , Yoe-Sik Bae , Youn-Dong Kim , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Hyunjoo Bae , Yoe-Sik Bae , Youn-Dong Kim , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
摘要： Disclosed are peptides having SEQ ID NOs: 1 to 32 that can stimulate superoxide generation in human monocytes. Superoxide is the most important armory on the primary defense line of monocytes against invading pathogens, and the identification of new stimuli and the characterization of the regulatory mechanism of superoxide generation are of paramount importance.
摘要翻译： 公开了具有可刺激人单核细胞中超氧化物产生的SEQ ID NO：1至32的肽。 超氧化物是单核细胞侵袭病原体的主要防御线上最重要的武器，新的刺激的鉴定和超氧化物产生的调节机制的表征是至关重要的。
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公开(公告)号：US07074891B2
公开(公告)日：2006-07-11
申请号：US10774147
申请日：2004-02-05
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。
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公开(公告)号：US20060166888A1
公开(公告)日：2006-07-27
申请号：US11277343
申请日：2006-03-23
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。
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公开(公告)号：US06887484B2
公开(公告)日：2005-05-03
申请号：US10209802
申请日：2002-07-31
申请人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
发明人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , C07K2319/00 , C12N2770/24222 , C12N2770/24234 , Y02A50/466
摘要： A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a peptide having the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2; and an immune activator.
摘要翻译： 具有良好疫苗接种效果的疫苗，其包含抗原; 选自具有SEQ ID NO：1的氨基酸序列的肽，具有SEQ ID NO：2的氨基酸序列的肽和源自SEQ ID NO：2的氨基酸序列的肽的肽的肽 ID NO：1或SEQ ID NO：2; 和免疫激活剂。
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公开(公告)号：US08017572B2
公开(公告)日：2011-09-13
申请号：US12246229
申请日：2008-10-06
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
摘要： Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
摘要翻译： 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1来刺激Akt磷酸化。
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公开(公告)号：US07622551B2
公开(公告)日：2009-11-24
申请号：US11277343
申请日：2006-03-23
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。 本申请还公开了使用所公开的肽的方法。
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公开(公告)号：US20090118197A1
公开(公告)日：2009-05-07
申请号：US12246229
申请日：2008-10-06
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Yoe-Sik Bae , Ji-Young Song
摘要： Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
摘要翻译： 公开了具有SEQ ID NO：1至24的肽，其诱导人单核细胞或嗜中性粒细胞产生超氧化物; 其诱导人外周血单核细胞或嗜中性粒细胞的细胞内钙增加; 结合甲酰肽受体或甲酰肽受体样1; 在体外诱导人单核细胞或嗜中性粒细胞趋化迁移; 其在表达甲酰基肽受体的细胞或甲酰肽受体样1表达细胞中诱导脱颗粒; 通过激活甲酰肽受体或甲酰肽受体样1刺激细胞外信号调节蛋白激酶磷酸化; 或通过激活甲酰肽受体或甲酰肽受体样1刺激Akt磷酸化。
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