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公开(公告)号:US10673328B2
公开(公告)日:2020-06-02
申请号:US15089744
申请日:2016-04-04
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Syed Bari , Fred C. Lee , Qiang Li
Abstract: An amount of charge transferred by a power converter is estimated by developing a signal that is a combination of signals representing an output voltage of a power converter and an inductor current of the power converter, charging a capacitor with a current proportional to that signal and comparing a voltage developed across the capacitor due to that charging to develop a signal for initiating a pulse to control input of power from a voltage source to the power converter. By using a signal developed in this way, response to both step-up and step-down transients can be improved and, in multi-phase embodiments, ripple cancellation problems such as noise susceptibility and loss of pulse generation can be entirely avoided.
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公开(公告)号:US10658928B2
公开(公告)日:2020-05-19
申请号:US16372101
申请日:2019-04-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Owen Jong , Qiang Li , Fred C. Lee
Abstract: Various examples are provided related to switched-capacitor converters (SCCs) with multi resonant frequencies. In one example, a multi resonant SCC (MRSCC) includes a series of switches coupled between an input voltage and an output connection; a pair of diodes coupled across the output connection; and a resonant circuit coupled at a first end between first and second switches of the series of switches and at a second end between the pair of diodes. The resonant circuit can comprise a resonant tank including a first capacitor and a resonant inductor, and a resonant component in parallel with at least a portion of the resonant tank. The resonant component can be connected across the resonant tank or across the resonant inductor. The MRSCC topology can also be used with higher voltage conversion ratio converters.
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公开(公告)号:US10562038B2
公开(公告)日:2020-02-18
申请号:US15786079
申请日:2017-10-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Roe-Hoan Yoon , Mert Kerem Eraydin
Abstract: Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.
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公开(公告)号:US10471254B2
公开(公告)日:2019-11-12
申请号:US15310114
申请日:2015-05-12
Applicant: Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Inventor: Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号:US20190340506A1
公开(公告)日:2019-11-07
申请号:US16416921
申请日:2019-05-20
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Timothy James O`Shea
Abstract: Methods, systems, and apparatus, including computer programs encoded on a storage medium, for processing radio signals. In once aspect, a system is disclosed that includes a processor and a storage device storing computer code that includes operations. The operations may include obtaining first output data generated by a first neural network based on the first neural network processing a received radio signal, receiving, by a signal transformer, a second set of input data that includes (i) the received radio signal and (ii) the first output data, generating, by the signal transformer, data representing a transformed radio signal by applying one or more transforms to the received radio signal, providing the data representing the transformed radio signal to a second neural network, obtaining second output data generated by the second neural network, and determining based on the second output data a set of information describing the received radio signal.
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公开(公告)号:US20190334434A1
公开(公告)日:2019-10-31
申请号:US16372101
申请日:2019-04-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Owen Jong , Qiang Li , Fred C. Lee
IPC: H02M3/07
Abstract: Various examples are provided related to switched-capacitor converters (SCCs) with multi resonant frequencies. In one example, a multi resonant SCC (MRSCC) includes a series of switches coupled between an input voltage and an output connection; a pair of diodes coupled across the output connection; and a resonant circuit coupled at a first end between first and second switches of the series of switches and at a second end between the pair of diodes. The resonant circuit can comprise a resonant tank including a first capacitor and a resonant inductor, and a resonant component in parallel with at least a portion of the resonant tank. The resonant component can be connected across the resonant tank or across the resonant inductor. The MRSCC topology can also be used with higher voltage conversion ratio converters.
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公开(公告)号:US10429526B2
公开(公告)日:2019-10-01
申请号:US16320941
申请日:2016-10-21
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Patrick Huber , Jonathan M. Link , Mariani Camillo
Abstract: A radiation detector and detection method comprising one or more antineutrino capture sections having a plurality of cells. The cells including hydrogen, act as scintillators and contain a wavelength shifter. Also included are a plurality of neutron capture layers containing a neutron capture agent. The cells are disposed between said neutron capture layers. The layers act as scintillators to convert the radiation emission of a neutron capture to light for transmission to at least one of the cells and the cells and layers have different scintillation time constants.
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68.
公开(公告)号:US10406219B2
公开(公告)日:2019-09-10
申请号:US15509381
申请日:2015-09-08
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor: Sriranganathan Nammalwar , Hamzeh Al Qublan , Garrett Smith , Stephen Boyle , Gerhardt Schurig
Abstract: Provided herein is a multivalent Brucella vaccine expressing at least one heterologous M. tuberculosis antigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for protection against Brucella and Mycobacterium infections simultaneously. In particular, a multivalent vaccine comprising a Brucella strain transformed with a vector that expresses at least one M. tuberculosis antigen, where the M. tuberculosis antigen(s) is codon optimized for the Brucella strain is provided. In some aspects, the Brucella strain is B. abortus strain RB51 leuB and the M. tuberculosis antigen is one or more of Ag85B, Rv2660c, and ESAT6.
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公开(公告)号:US20190175260A1
公开(公告)日:2019-06-13
申请号:US16275429
申请日:2019-02-14
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor: Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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70.
公开(公告)号:US10291109B2
公开(公告)日:2019-05-14
申请号:US15868486
申请日:2018-01-11
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor: Zhengrong Huang , Zhengyang Liu , Fred C. Lee , Qiang Li , Furong Xiao
Abstract: Critical-mode soft-switching techniques for a power converter are described. In one example, a power converter includes a converter electrically coupled between an alternating current (AC) power system and a direct current (DC) power system, where the converter includes a number of phase legs. The power converter can also include a control system configured, during a portion of a whole line cycle of the AC power system, to clamp a first phase leg of the converter from switching and operate second and third phase legs of the converter independently in either critical conduction mode (CRM) or in discontinuous conduction mode (DCM).
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