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公开(公告)号：US12173280B2
公开(公告)日：2024-12-24
申请号：US18120158
申请日：2023-03-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11737810B2
公开(公告)日：2023-08-29
申请号：US17069359
申请日：2020-10-13
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61N1/327 , C12N13/00 , A61B2018/00446 , A61B2018/00577 , A61B2018/00613 , A61B2034/104 , A61N1/05
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US20190133671A1
公开(公告)日：2019-05-09
申请号：US16232962
申请日：2018-12-26
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US20150164584A1
公开(公告)日：2015-06-18
申请号：US14627046
申请日：2015-02-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
CPC classification number: A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
Abstract translation: 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 包括用电能处理组织的方法，所述方法包括：使用包括一个或多个电极的一个或多个电穿孔装置将电能传送到组织; 以及冷却组织，周围组织，一个或多个电极或一个或多个电穿孔装置以使加热最小化。 在实施方案中，本发明可用于治疗实体瘤，例如脑肿瘤，并且在一些实施方案中，示例性方法依赖于非热不可逆电穿孔（IRE）以在治疗的肿瘤中引起细胞死亡。
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公开(公告)号：US20230212551A1
公开(公告)日：2023-07-06
申请号：US18120158
申请日：2023-03-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
IPC: A61B18/14
CPC classification number: A61B18/1477 , A61B2018/00577
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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Patent Agency Ranking
公开(公告)号：US20210186600A1
公开(公告)日：2021-06-24
申请号：US17172731
申请日：2021-02-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US10828085B2
公开(公告)日：2020-11-10
申请号：US16177745
申请日：2018-11-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US20200093541A9
公开(公告)日：2020-03-26
申请号：US14808679
申请日：2015-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US10245098B2
公开(公告)日：2019-04-02
申请号：US14017210
申请日：2013-09-03
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain.
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公开(公告)号：US20240008911A1
公开(公告)日：2024-01-11
申请号：US18348605
申请日：2023-07-07
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61N1/327 , C12N13/00 , A61B2018/00446
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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