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公开(公告)号：US11618832B2
公开(公告)日：2023-04-04
申请号：US16325991
申请日：2017-08-17
发明人： Maruti Hegde , Timothy E. Long , Viswanath Meenakshisundaram , Christopher B. Williams , Nicholas Chartrain
IPC分类号： C08F2/46 , C08F2/50 , C08G61/04 , C09D11/101 , B33Y70/00 , C09D11/102 , B33Y10/00 , B29C64/135
摘要： Polymer resins for the vat photopolymerization of thermoplastics are provided, in particular for the vat photopolymerization of thermoplastics with exception thermal stability and mechanical properties. In some aspects, the polymer resins are prepared by ring opening of an aromatic dianhydride with an alcohol containing an acrylate or methacrylate to produce a photocrosslinkable diacid monomer; conversion of the photocrosslinkable diacid monomer to a photocrosslinkable diacyl chloride; and polymerization of the photocrosslinkable diacyl chloride with an aromatic diamine to produce a photocrosslinkable precursor polymer. Upon crosslinking and drying, a thermal imidization can yield aromatic polyimide polymers with high yield and with micron-scale structural resolution.
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公开(公告)号：US11611289B2
公开(公告)日：2023-03-21
申请号：US17378941
申请日：2021-07-19
发明人： Jian Liu , Dong Dong , Rolando Burgos
摘要： Aspects are described for hybrid modular multilevel converters that include half-bridge submodules. In some embodiments, a hybrid modular multilevel converter can include a direct current (DC) bus and an alternating current (AC) node. A first arm of the hybrid modular multilevel converter includes a first submodule chain link and a first arm inductor and a second arm includes a second submodule chain link and a second arm inductor. A capacitor connects between a first side of the first arm and a first side of the second arm.
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公开(公告)号：US11607537B2
公开(公告)日：2023-03-21
申请号：US16210771
申请日：2018-12-05
发明人： Eduardo Latouche , Samuel Lesko , Lucy Epshteyn , Christopher B. Arena , John H. Rossmeisl, Jr. , Melvin Lorenzo , Rafael Davalos
摘要： This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.
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公开(公告)号：US20230050649A1
公开(公告)日：2023-02-16
申请号：US17305773
申请日：2021-07-14
IPC分类号： C07D413/14 , C07D413/04
摘要： Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds.
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公开(公告)号：US20230026670A1
公开(公告)日：2023-01-26
申请号：US17378941
申请日：2021-07-19
发明人： Jian Liu , Dong Dong , Rolando Burgos
摘要： Aspects are described for hybrid modular multilevel converters that include half-bridge submodules. In some embodiments, a hybrid modular multilevel converter can include a direct current (DC) bus and an alternating current (AC) node. A first arm of the hybrid modular multilevel converter includes a first submodule chain link and a first arm inductor and a second arm includes a second submodule chain link and a second arm inductor. A capacitor connects between a first side of the first arm and a first side of the second arm.
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公开(公告)号：US20220388617A1
公开(公告)日：2022-12-08
申请号：US17531007
申请日：2021-11-19
摘要： Various examples of a high-speed omnidirectional fully-actuated underwater propulsion mechanism are described. In one example, a propulsion system includes two decoupled counter-rotating rotors centered on a main axis, with each rotor comprising a plurality of pivotable blades projecting radially from the main axis, a servo-swashplate actuation mechanism comprising a plurality of servos and a linkage assembly connected from the servos to the pivotable blades, a blade-axis re-enforcing flap adapter comprising a plurality of stationary flaps, with the blade-axis re-enforcing flap adapter being positioned in a region between the two decoupled counter-rotating rotors centered on the main axis, and a controller. The controller can be configured to calculate control parameters, compensate a first control parameter among the control parameters to reduce cross-coupling of an unwanted force generated by drag forces on the two decoupled counter-rotating rotors, and generate a control signal for each of the servos based on the control parameters.
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公开(公告)号：US11519877B2
公开(公告)日：2022-12-06
申请号：US16058478
申请日：2018-08-08
IPC分类号： B03C5/00 , B03C5/02 , G01N27/447 , B01D57/02
摘要： Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
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公开(公告)号：US20220385193A1
公开(公告)日：2022-12-01
申请号：US17765611
申请日：2020-09-30
发明人： Jih-Sheng Lai , Chih-Shen Yeh
IPC分类号： H02M3/335 , H02M3/00 , H02M1/08 , H02M1/00 , H02M7/5387
摘要： Aspects of hybrid modulation control for DC-to-AC converters are described. In one embodiment, a hybrid modulation pattern is generated. The hybrid modulation pattern separates switch gating control into multiple control regions for a half cycle of the waveform. A first control region modulates according to a first modulation technique and a second control region modulates according to a second modulation technique. The switches of a resonant converter are controlled according to the hybrid modulation pattern to generate the waveform.
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公开(公告)号：US20220371181A1
公开(公告)日：2022-11-24
申请号：US17813772
申请日：2022-07-20
IPC分类号： B25J9/10 , B25J9/16 , B62D57/032 , B25J19/00 , B25J17/00
摘要： The present invention concerns a novel leg mechanism for quadrupedal locomotion. This design engages a linkage to couple assembly that only requires a single degree of actuation. The topological arrangement of the system produces a foot trajectory that is well-suited for dynamic gaits including trot-running, bounding, and galloping.
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公开(公告)号：US11453873B2
公开(公告)日：2022-09-27
申请号：US16535451
申请日：2019-08-08
发明人： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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