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    Protein for blocking platelet adhesion
    62.
    发明授权
    Protein for blocking platelet adhesion 有权

    公开(公告)号：US07090986B2

    公开(公告)日：2006-08-15

    申请号：US11153433

    申请日：2005-06-16

    申请人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

    发明人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

    IPC分类号： G01N33/53

    CPC分类号： C07K14/43536 ,  A61K38/00

    摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

    Electrooptical system
    66.
    发明授权
    Electrooptical system 失效

    公开(公告)号：US06327010B1

    公开(公告)日：2001-12-04

    申请号：US08769517

    申请日：1996-12-19

    申请人： Bernhard Scheuble ,  Günter Baur ,  Waltraud Fehrenbach ,  Barbara Staudacher

    发明人： Bernhard Scheuble ,  Günter Baur ,  Waltraud Fehrenbach ,  Barbara Staudacher

    IPC分类号： G02F11335

    CPC分类号： G02F1/13363 ,  G02F1/1396 ,  G02F2001/133531

    摘要： An electrooptical system contains: (a) a twisted nematic liquid-crystal layer, with an input side and an output side, which is positioned between a first substrate and a second substrate, each of whose inside surface is provided with an electrode coating and an alignment layer thereon, the director of said liquid crystal layer having a parallel edge alignment and a twist angle of 0°≦&bgr;≦1000, (b) at least one compensation layer for compensating the optical path difference of the liquid-crystal layer d·&Dgr;n, and (c) at least one device for linear polarization of light in such an arrangement that light, before entering and after exiting the liquid-crystal layer, passes through a polarization device, I. wherein, in order to achieve high contrast, and/or high brightness, and/or high viewing angle independence of the contrast and/or the color values, the angle &psgr;, which the polarization device on the input side of the liquid crystal layer forms with the director of the liquid-crystal molecules on the surface of the first substrate, satisfies I.A. condition (1) or (2) &psgr;=(&bgr;+90°)/2±10°  (1) &psgr;=&bgr;/2±10°  (2) where a polarization device is present on both the light input side of the liquid crystal layer and the light output side of the liquid crystal layer, and the polarization device on the output side of the liquid crystal layer is rotated by 90°±10° with respect to the polarization device on the input side of the liquid crystal layer, and, optionally, alignment of the polarization devices on the input side and the output side of the liquid crystal layer are interchanged, or satisfies I.B. condition (3) or (4) 30°≦&psgr;≦70° for 0≦&bgr;≦45°  (3) 35°≦&psgr;≦90° for 45≦&bgr;100°  (4), where a polarization device is only present on the input side, II. wherein the compensation layer comprises a material having three optical refractive indices, of which one is less than the other two, and wherein the optical axis corresponding to this lowest refractive index is essentially parallel to the surface of said second substrate or forms an angle of 2°

    Difluorobenzonitriles and liquid-crystalline medium
    69.
    发明授权
    Difluorobenzonitriles and liquid-crystalline medium 失效
    二氟甲苯和液晶中间体

    公开(公告)号：US5204017A

    公开(公告)日：1993-04-20

    申请号：US623387

    申请日：1990-11-19

    申请人： Volker Reiffenrath ,  Hans-Adolf Kurmeier ,  Bernhard Scheuble

    发明人： Volker Reiffenrath ,  Hans-Adolf Kurmeier ,  Bernhard Scheuble

    IPC分类号： C07D213/57 ,  C07D213/65 ,  C07D239/26 ,  C07D239/34 ,  C09K19/34

    CPC分类号： C07D239/26 ,  C07D213/57 ,  C07D213/65 ,  C07D239/34 ,  C09K19/3444 ,  C09K19/3469

    摘要： Difluorobenzonitriles of the formula I ##STR1## in which Y is alkyl, alkenyl, alkoxy, oxaalkyl or alkenyloxy containing in each case 1 to 12 carbon atoms,one of the radicals A.sup.1 and A.sup.2 present in the molecule is ##STR2## where X is CH or N, and the other radical A.sup.1 or A.sup.2 is selected from the group comprising ##STR3## one of the radicals Z.sup.1 and Z.sup.2 is a single bond and the other radical Z.sup.1 or Z.sup.2 is --CH.sub.2 CH.sub.2 -- or a single bond, andm is 0 or 1, with the proviso that if m=1, Z.sup.1 =Z.sup.2 - single bond and one of the radicals A.sup.1 and A.sup.2 =2,5-pyrimidinediyl and the other radical A.sup.1 or A.sup.2 =1,4-phenylene, A.sup.1 is 2,5-pyrimidinediyl.

    摘要翻译： PCT No.PCT / EP90 / 01412 Sec。 371日期1990年11月19日 102（e）1990年11月19日日期PCT提交1990年8月24日PCT公布。 公开号WO91 / 03468 1991年3月21日。式I的二氟苯并噻吩其中Y是在每种情况下含有1至12个碳原子的烷基，烯基，烷氧基，氧杂烷基或烯氧基，分子中存在的基团A1和A2之一 其中X是CH或N，另一个基团A1或A2选自基团，其中一个基团Z 1和Z 2是单键，另一个基团Z 1或Z 2是-CH 2 CH 2 - 或 m为0或1，条件是如果m = 1，则Z1 = Z2-单键，基团A1和A2之一= 2,5-嘧啶二基，另一个基团A1或A2 = 1， 4-亚苯基，A1是2,5-嘧啶二基。