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1.发明授权Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors 失效单结构域配体，包含所述配体的用于其生产的方法的受体，以及所述配体和受体的使用公开(公告)号：US06248516B1
公开(公告)日：2001-06-19
申请号：US08470031
申请日：1995-06-06
IPC分类号： C12Q168
CPC分类号： C07K16/461 , A61K38/00 , C07K2317/24 , C12Q1/6876
摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis and catalysis.
摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断和催化中的用途。
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2.发明授权Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors 失效单结构域配体，包含所述配体的受体，其制备方法和所述配体和受体的用途公开(公告)号：US07306907B2
公开(公告)日：2007-12-11
申请号：US10290252
申请日：2002-11-08
IPC分类号： C12Q1/68
CPC分类号： C07K16/461 , A61K38/00 , C07K2317/24 , C12Q1/6876
摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis or catalysis.
摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断或催化中的用途。
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公开(公告)号：US06774107B1
公开(公告)日：2004-08-10
申请号：US09936737
申请日：2001-09-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： A61K3817
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译： 描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。 蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。 对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。 公开了通过重组技术生产这种多肽的方法。 重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。 此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。
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4.发明授权Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors 失效单结构域配体，包含所述配体的受体，其制备方法和所述配体和受体的用途公开(公告)号：US06545142B1
公开(公告)日：2003-04-08
申请号：US09722364
申请日：2000-11-28
IPC分类号： C07H2104
CPC分类号： C07K16/461 , A61K38/00 , C07K2317/24 , C12Q1/6876
摘要： The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the production of Ig-type molecules and said ligands or receptors, and the use of said ligands or receptors in therapy, diagnosis or catalysis.
摘要翻译： 本发明涉及衍生自免疫球蛋白（Ig）超家族中的分子的单结构域配体，包含至少一种这样的配体的受体，用于克隆，扩增和表达编码这种配体的DNA序列的方法，优选使用聚合酶链式反应， 在产生Ig型分子和所述配体或受体中使用所述DNA序列，以及所述配体或受体在治疗，诊断或催化中的用途。
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公开(公告)号：US07090986B2
公开(公告)日：2006-08-15
申请号：US11153433
申请日：2005-06-16
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/53
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
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公开(公告)号：US06962801B2
公开(公告)日：2005-11-08
申请号：US10846668
申请日：2004-05-17
申请人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
发明人： Wolfgang Strittmatter , Detlef Güssow , Uwe Hofmann , Jürgen Hemberger , Zisi Fotev , Bernhard Scheuble
IPC分类号： G01N33/50 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/46 , A61L27/00 , A61P7/02 , C07K14/435 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/566 , C07H21/04 , C12N15/63
CPC分类号： C07K14/43536 , A61K38/00
摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
摘要翻译： 描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。 蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。 对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。 公开了通过重组技术生产这种多肽的方法。 重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与硬疾病和循环系统疾病有关的各种疾病。 此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并防止细胞的活化。
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