公开(公告)号：US07946108B2

公开(公告)日：2011-05-24

申请号：US10584237

申请日：2004-12-01

申请人： Jens Franz ,  Uwe Hofmann

发明人： Jens Franz ,  Uwe Hofmann

IPC分类号： F01N3/00

CPC分类号： F02D41/028 ,  F02D41/146 ,  F02D41/1475

摘要： In a method for regenerating a nitrogen oxide storage catalytic converter arranged in an exhaust pipe of an internal combustion engine, a constant value is set in a first regeneration phase for the air/fuel ratio λM of the air/fuel mixture fed to the internal combustion engine when a predeterminable triggering threshold value for the nitrogen oxide concentration in the exhaust gas on the output side of the nitrogen oxide storage catalytic converter is exceeded. The first regeneration phase is followed by a second regeneration phase, in which the time rate of change d λM/dt of the air/fuel ratio λM is set as a function of the mass flow of the exhaust gas flowing through the nitrogen oxide storage catalytic converter or as a function of an internal combustion engine operating variable linked with the mass flow of exhaust gas.

摘要翻译： 在再生设置在内燃机的排气管中的氮氧化物存储催化转化器的方法中，在供给到内燃机的空气/燃料混合物的空燃比λM的第一再生阶段中设定恒定值 当氮氧化物存储催化转化器的输出侧的废气中的氮氧化物浓度超过预定的触发阈值时，发动机。 第一再生阶段之后是第二再生阶段，其中将空气/燃料比λM的时间变化率dλM/ dt设定为流过氮氧化物储存催化剂的废气的质量流量的函数 转换器或作为与废气质量流相关联的内燃机操作变量的函数。

公开(公告)号：US20080206800A1

公开(公告)日：2008-08-28

申请号：US11995742

申请日：2006-07-07

申请人： Tanja Henzler ,  Bjoern Hock ,  Andree Blaukat ,  Uwe Hofmann

发明人： Tanja Henzler ,  Bjoern Hock ,  Andree Blaukat ,  Uwe Hofmann

IPC分类号： C12Q1/48 ,  C07K16/18

CPC分类号： C12Q1/485

摘要： Method, kit and composition for measuring the autophosphorylation of one or more tyrosine kinases in presence of a kinase inhibitor compared to the absence of said kinase inhibitor for kinase specificity profiling of kinase inhibitors.

摘要翻译： 用于在激酶抑制剂存在下测量一种或多种酪氨酸激酶的自磷酸化的方法，试剂盒和组合物与不存在用于激酶抑制剂的激酶特异性分析的所述激酶抑制剂相比。

公开(公告)号：US20060192908A1

公开(公告)日：2006-08-31

申请号：US10532951

申请日：2004-09-02

申请人： Wolfgang Tzschoppe ,  Thomas Brueggert ,  Markus Klippstein ,  Ingo Relke ,  Uwe Hofmann

发明人： Wolfgang Tzschoppe ,  Thomas Brueggert ,  Markus Klippstein ,  Ingo Relke ,  Uwe Hofmann

IPC分类号： G02F1/1335

CPC分类号： H04N13/361 ,  H04N13/359

摘要： An arrangement for the display of images with selectable three-dimensionally visible or two-dimensional modes, including an illuminating device a filter array to impart a structure to the light a diffusing layer, and a transmissive image display device, with a variable distance a between the filter array and the diffusing layer, so that in a first position, the structure imparted by the filter array is essentially cancelled due to the light diffusion effect of the diffusing layer, and a two-dimensional image is shown, and the structure imparted by the filter array is essentially not cancelled, so that the image display device shows a three-dimensional image.

摘要翻译： 用于显示具有可选择的三维可见或二维模式的图像的装置，包括照明装置，用于向散射层赋予光的结构的滤光器阵列，以及透射图像显示装置，其间具有可变距离a 滤光器阵列和扩散层，使得在第一位置，由于扩散层的光漫射效应，由滤光器阵列施加的结构基本上被抵消，并且示出了二维图像，并且由 滤波器阵列基本上不被取消，使得图像显示装置显示三维图像。

公开(公告)号：US07049124B1

公开(公告)日：2006-05-23

申请号：US10009500

申请日：2000-06-06

申请人： Maria Kordowicz ,  Detlef Gussow ,  Uwe Hofmann ,  Tadeusz Pacuszka ,  Andrzej Gardas

发明人： Maria Kordowicz ,  Detlef Gussow ,  Uwe Hofmann ,  Tadeusz Pacuszka ,  Andrzej Gardas

IPC分类号： C12N9/26 ,  C12N9/88 ,  C12N15/56 ,  C12N15/66 ,  A61K38/47 ,  A61K38/51

CPC分类号： C12N9/2408 ,  A61K38/00

摘要： The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech Hirudinaria manillensis. Therefore, according to this invention, the enzyme was called “manillase”. The invention is furthermore concerned with the recombinant method of production of manillase which includes the disclosure of DNA and amino acid sequences as well as of expression vectors and host systems. Finally, the invention relates to the use of manillase for therapeutic purposes, for example, for the treatment of myocardial diseases, thrombotic events and tumors.

摘要翻译： 本发明涉及从热带水蛭Hirudinaria manillensis得到的透明质酸酶的分离，纯化和表征。 因此，根据本发明，酶被称为“芒硝酶”。 本发明进一步涉及重组芽胞杆菌的生产方法，其包括DNA和氨基酸序列以及表达载体和宿主系统的公开。 最后，本发明涉及用于治疗目的的芒硝酶的用途，例如用于治疗心肌疾病，血栓形成事件和肿瘤。

公开(公告)号：US06346215B1

公开(公告)日：2002-02-12

申请号：US09595289

申请日：2000-06-15

申请人： Andreas Boegel ,  Stephan Hansmann ,  Uwe Hofmann ,  Hilmar R. Mueller ,  Joachim Riedle

发明人： Andreas Boegel ,  Stephan Hansmann ,  Uwe Hofmann ,  Hilmar R. Mueller ,  Joachim Riedle

IPC分类号： C22C902

CPC分类号： B22F3/115 ,  C22C1/0425 ,  C22C9/02 ,  C22C9/04 ,  C22C9/05

摘要： A copper alloy contains from 4 to 20 wt. % tin and various other metals. The alloys can be used in the manufacture of structural parts which are joined together through the use of heat such as jewelry, clothing accessories and mechanically stressed structural parts in a general machine-building or automotive industry. Iron, titanium, zirconium, hafnium, manganese, zinc, phosphorus and lead can also be present in the alloy composition.

摘要翻译： 铜合金含有4〜20wt。 锡和各种其他金属。 该合金可用于制造通过使用诸如首饰，服装配件和机械应力结构部件的热量在通用机械制造或汽车工业中连接在一起的结构部件。 铁，钛，锆，铪，锰，锌，磷和铅也可以存在于合金组合物中。

公开(公告)号：US06979726B1

公开(公告)日：2005-12-27

申请号：US08362951

申请日：1994-12-23

申请人： Ilka von Hoegen ,  Uwe Hofmann ,  Carlota-Silvia Jaggle ,  Wolfgang Strittmatter ,  Jörg Stadlmüller ,  Siegfried Matzku

发明人： Ilka von Hoegen ,  Uwe Hofmann ,  Carlota-Silvia Jaggle ,  Wolfgang Strittmatter ,  Jörg Stadlmüller ,  Siegfried Matzku

IPC分类号： C12N15/09 ,  A61K20060101 ,  A61K38/00 ,  A61K38/16 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K39/00 ,  A61K39/295 ,  A61K39/395 ,  A61K39/44 ,  A61K47/48 ,  A61P35/00 ,  A61P35/04 ,  C07K20060101 ,  C07K14/52 ,  C07K14/525 ,  C07K14/54 ,  C07K14/55 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/42 ,  C07K16/46 ,  C07K19/00 ,  C12N20060101 ,  C12N15/13 ,  C12N15/19 ,  C12N15/55 ,  C12N15/62 ,  C12N15/64 ,  C12N15/72 ,  C12N15/79 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/5406 ,  C07K14/5418 ,  C07K14/55 ,  C07K16/2863 ,  C07K2319/00 ,  C12N2799/028

摘要： The present invention relates to new fusion proteins which consist of a tumor-associated targeting element preferentially a monoclonal antibody or a fragment thereof recognizing a molecule which is preferentially expressed on human tumor cells such as the human epidermal growth factor receptor (EGFR), and a biologically active ligand such as a growth and/or differentiation factor. The resulting fusion protein may be used to deliver the biologically active ligand to a specific target cell or tissue. The new immunoconjugates can be used in tumor therapy.

摘要翻译： 本发明涉及由肿瘤相关靶向元件优选单克隆抗体或其片段识别优先表达人肿瘤细胞如人表皮生长因子受体（EGFR）的分子组成的新融合蛋白，以及 生物活性配体如生长和/或分化因子。 所得的融合蛋白可用于将生物活性配体递送至特定的靶细胞或组织。 新的免疫缀合物可用于肿瘤治疗。

公开(公告)号：US06360936B1

公开(公告)日：2002-03-26

申请号：US09670111

申请日：2000-09-26

申请人： Christoph Dilg ,  Uwe Hofmann ,  Claus Just ,  Hans-Jürgen Rögele ,  Helmut Schönberger ,  Jürgen Vogt

发明人： Christoph Dilg ,  Uwe Hofmann ,  Claus Just ,  Hans-Jürgen Rögele ,  Helmut Schönberger ,  Jürgen Vogt

IPC分类号： B23K2008

CPC分类号： B32B15/011 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/105 ,  C22C38/12 ,  C22C38/14 ,  C22C38/16 ,  C22C38/44 ,  C22C38/50 ,  C22C38/52 ,  F41H5/045 ,  Y10T428/12653

摘要： In a method of manufacturing composite sheet steel of maraging steel, wherein the composite sheet steel comprises an outer layer and an inner layer, wherein the outer layer is harder than the inner layer and the inner layer is more tenacious than the outer layer, the steel of the inner layer is produced with a chemical composition containing in percent by weight: C≦0.01, Si≦0.1, Mn≦0.1, P≦0.005, S≦0.005, Cu≦0.1, Mo 4.80 to 5.20, Ni 17.5 to 18.5 , Cr≦0.1, Ti 0.55 to 0.70, Co 8.0 to 9.0; and the steel of the outer layer is produced with purification in a zone melting process with a chemical composition containing in percent by weight: C≦0.01, Si

摘要翻译： 在制造马氏体时效钢复合钢板的方法中，其中复合钢板包括外层和内层，其中外层比内层硬，内层比外层更坚固，钢 以含有重量百分比的化学成分制造内层：C <0.01，Si <= 0.1，Mn <= 0.1，P <= 0.005，S <0.005，Cu <= 0.1，Mo 4.80〜5.20 ，Ni 17.5〜18.5，Cr <= 0.1，Ti 0.55〜0.70，Co 8.0〜9.0; 并且外层的钢是以化学成分含量为重量百分比的区域熔融法纯化生产的：C <0.01，Si <0.1，Mn 0.02〜0.20，P <= 0.005，S <0.005， Cu 0.01〜0.20，Mo 4.80〜5.20，Ni 17.5〜18.5，Cr 0.01〜0.20，Ti 1.80〜1.95，Co 14.0〜15.5，Al：0.05〜0.15，余量分别为Fe和制造工序产生的杂质。 复合板钢被用作防止射击和爆炸物的影响。

公开(公告)号：US6136103A

公开(公告)日：2000-10-24

申请号：US212524

申请日：1998-12-16

申请人： Andreas Boegel ,  Stephan Hansmann ,  Uwe Hofmann ,  Hilmar R. Mueller ,  Joachim Riedle

发明人： Andreas Boegel ,  Stephan Hansmann ,  Uwe Hofmann ,  Hilmar R. Mueller ,  Joachim Riedle

IPC分类号： B22F3/115 ,  C22C1/04 ,  C22C9/02

CPC分类号： B22F3/115 ,  C22C1/0425 ,  C22C9/02

摘要： A copper-tin-titanium alloy which consists of 12 to 20% by weight tin, 0.002 to 1% by weight titanium, remainder copper and usual impurities. It is possible to add further elements. Semifinished products made from the copper alloy according to the invention are preferably produced by thin-strip casting or spray compacting. Due to a particularly advantageous combination of high mechanical strength properties with excellent ductility, combined with good resistance to corrosion, semifinished products made from the copper alloy according to the invention have numerous possible uses.

摘要翻译： 一种铜 - 锡 - 钛合金，其由12至20重量％的锡，0.002至1重量％的钛，余量为铜和常规杂质组成。 可以添加更多元素。 由本发明的铜合金制成的半成品优选通过薄带铸造或喷雾压制来制造。 由于具有优异的延展性的高机械强度性能和良好的耐腐蚀性的特别有利的组合，由本发明的铜合金制成的半成品具有许多可能的用途。

公开(公告)号：US6074550A

公开(公告)日：2000-06-13

申请号：US113269

申请日：1998-07-10

申请人： Uwe Hofmann ,  Knut Sauerbier

发明人： Uwe Hofmann ,  Knut Sauerbier

IPC分类号： B01J47/14 ,  C02F1/00 ,  B01D17/12 ,  B01D35/143

CPC分类号： B01J47/14 ,  C02F1/003 ,  C02F2209/445 ,  C02F2307/04

摘要： A device is described for indicating the depletion of a purifying agent contained in an insert of a water purifying apparatus (7). In order to produce such a device better, to improve it technically, to construct it so as to be user-friendly and also more moderate in price, provision is made according to the invention that an indicator apparatus (1) is arranged in order to indicate to the user the depletion of the purifying agent as a function of the quantity of water which has run through the purifying agent; or alternatively to indicate to the user the depletion as a function of the quantity of water which has run through the purifying agent and as a function of time; in which preferably the indicator apparatus is connected with an arrangement which is arranged on a part (3) movable relative to the insert and which on this movement triggers a switching process.

摘要翻译： 描述了用于指示包含在净水设备（7）的插入件中的净化剂的耗尽的装置。 为了更好地生产这样的装置，为了在技术上制造这样的装置，为了构造它以便于用户友好并且价格更温和，根据本发明提供了一种指示装置（1），以便 向使用者指示净化剂的消耗作为穿过净化剂的水的量的函数; 或者替代地向用户指示作为穿过净化剂的水的量的函数和随时间的函数的消耗; 其中优选地，指示器装置与布置在相对于插入件可移动的部件（3）上的装置连接，并且在该移动触发切换过程。

公开(公告)号：US20140199219A1

公开(公告)日：2014-07-17

申请号：US14232026

申请日：2012-06-29

申请人： Bernd Christner ,  Uwe Hofmann ,  Tobias Peters

发明人： Bernd Christner ,  Uwe Hofmann ,  Tobias Peters

IPC分类号： B01D53/94

CPC分类号： B01D53/9431 ,  F01N3/208 ,  F01N9/00 ,  F01N2610/02 ,  F01N2900/1818 ,  Y02T10/24 ,  Y02T10/47

摘要： A determination of a quality of a reducing agent solution containing ammonia used to reduce nitrogen oxides involves actuating a metering unit that delivers metered quantities of reducing agent solution into an engine's discharged exhaust gas and determining an efficiency value that is at least correlated with the efficiency of the SCR catalytic converter and comparing the efficiency value to a predefinable limit value. If an efficiency value not corresponding to proper functioning of the SCR exhaust emission control system is identified by the comparison, a switch is made to a diagnostic mode in a second method step. If a predefinable deviation of the efficiency value from a limit value is identified after expiration of the second method step time period, a third method step is performed for conditioning the SCR catalytic converter. A fourth step involves an adaptation mode in which a deviation from the efficiency value is determined.

摘要翻译： 确定含有用于还原氮氧化物的氨的还原剂溶液的质量包括启动计量单元，该计量单元将计量的还原剂溶液输送到发动机的排出的废气中，并确定至少与效率值相关的效率值 SCR催化转化器，并将效率值与预定义极限值进行比较。 如果通过比较来识别与SCR废气排放控制系统的正常功能不对应的效率值，则在第二方法步骤中进行诊断模式的切换。 如果在第二方法步骤时间段结束之后确定效率值与极限值的预定义偏差，则执行第三方法步骤以调节SCR催化转化器。 第四步涉及确定与效率值的偏差的适应模式。