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公开(公告)号：US11779659B2
公开(公告)日：2023-10-10
申请号：US17565842
申请日：2021-12-30
Applicant: BioNTech SE
Inventor： Ugur Sahin , Gábor Boros , Azita Josefine Mahiny , Jonas Reinholz , Katalin Karikó
IPC: A61K48/00 , A61P35/00 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K9/127 , A61K39/215 , C12N7/00 , A61P31/14 , A61K9/00 , A61K9/51 , A61K31/7105 , A61K31/7115 , A61K31/712 , B82Y5/00 , C12N15/11 , C12N15/67 , C12N15/88 , C12P19/34 , A61K31/711 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/0019 , A61K9/1271 , A61K9/5123 , A61K9/5146 , A61K31/7088 , A61K31/711 , A61K31/712 , A61K31/7105 , A61K31/7115 , A61K39/0011 , A61K39/12 , A61K39/215 , A61K48/0033 , A61P31/14 , A61P35/00 , B82Y5/00 , C12N7/00 , C12N15/11 , C12N15/67 , C12N15/88 , C12P19/34 , A61K38/00 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , C12N2770/18022 , C12N2770/18034 , C12N2770/18071 , C12N2770/20034 , C12N2840/00
Abstract: Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
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公开(公告)号：US20230226217A1
公开(公告)日：2023-07-20
申请号：US18071705
申请日：2022-11-30
Applicant: TRON-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz ad , BioNTech SE
Inventor： Ugur Sahin , Heinrich Haas , Sebastian Kreiter , Mustafa Diken , Daniel Fritz , Martin Meng , Lena Mareen Kranz , Kerstin Reuter
CPC classification number: A61K48/0033 , A61K9/1272 , A61K39/0011 , A61K48/0025 , A61K2039/53 , A61K2039/55555
Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：US20230201817A1
公开(公告)日：2023-06-29
申请号：US18085206
申请日：2022-12-20
Applicant: BioNTech Delivery Technologies GmbH , BioNTech SE
Inventor： Christian Reinsch , David Estapé Izquierdo , Sierk Poetting , Ugur Sahin , Alexander Muik , Asaf Poran , Martin Lang , Oliver Hennig , Karsten Pietron-Kattmann , Manfred Brunen , Rainer Kröner , Mario Büttner , Sven Stegmann , Kristin Hoffmann
CPC classification number: B01L1/52 , A61K39/215 , B01D61/145 , B01D61/147 , B01D61/149 , B01F25/25 , G16B20/20 , G16B30/00 , G16B50/30 , A61K2039/53
Abstract: A portable system for producing a formulation comprising lipid nanoparticle (LNP)-encapsulated RNA includes: a first sub-system comprising multiple drug substance formulation modules, the first sub-system comprising: a transcription module for forming an RNA solution via in vitro transcription; and a second sub-system operatively downstream of the first sub-system comprising multiple drug product formation modules, the second sub-system comprising: an LNP formulation module for producing a first RNA-LNP preparation from the RNA solution, wherein each of the transcription module and the LNP formulation module is contained within a separate standard shipping container.
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公开(公告)号：US11660338B2
公开(公告)日：2023-05-30
申请号：US16749012
申请日：2020-01-22
Applicant: BIONTECH SE , TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES Gutenberg-Universitat Mainz Gemeinnutzige GmbH
Inventor： Ugur Sahin , Heinrich Haas , Sebastian Kreiter , Yves Hüsemann , Mustafa Diken , Kerstin Reuter , Hossam Hefesha
CPC classification number: A61K39/39 , A61K9/1271 , A61K9/1277 , A61K9/5073 , A61K31/675 , A61K39/0011 , C12N15/88 , A61K2039/55505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/572 , C12N2810/10
Abstract: The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present invention relates to a pharmaceutical composition comprising RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes.
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公开(公告)号：US20220313811A1
公开(公告)日：2022-10-06
申请号：US17717645
申请日：2022-04-11
Applicant: BIONTECH SE , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
Inventor： Ugur Sahin , Heinrich Haas , Annette Vogel , Daniel Zucker , Stephanie Erbar , Kerstin Walzer , Anne Schlegel , Sebastian Hörner , Sebastian Kreiter , Mustafa Diken , Jorge Moreno Herrero
Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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Patent Agency Ranking
公开(公告)号：US11248264B2
公开(公告)日：2022-02-15
申请号：US16920286
申请日：2020-07-02
Applicant: TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH , BioNTech SE
Inventor： Ugur Sahin , Sebastian Kreiter , Mustafa Diken , Jan Diekmann , Michael Koslowski , Cedrik Britten , John Christopher Castle , Martin Löwer , Bernhard Renard , Tana Omokoko , Johannes Hendrikus De Graaf
IPC: A61K39/00 , C12Q1/6869 , G16B20/00 , G16B40/00 , C12Q1/6886 , G16B20/20
Abstract: The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：US20210283177A1
公开(公告)日：2021-09-16
申请号：US16478615
申请日：2018-09-17
Applicant: Biontech SE , University of Verona
Inventor： Ugur Sahin , Vincenzo Bronte , Stefano Ugel , Alessandra Fiore
IPC: A61K35/15 , C07K14/47 , C12N5/0786 , C12N5/0775 , A61P37/06
Abstract: The present invention relates to cells which are engineered so as to increase the cellular level of cellular FLICE [Fas-associated death domain (FADD)-like IL-1β-converting enzyme]—inhibitory protein (CFLAR). The engineered cells have the ability to induce tolerance. Enhanced tolerogenicity is useful for prolonging survival of a foreign transplant and for treatment of autoimmune diseases.
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公开(公告)号：US20240390524A1
公开(公告)日：2024-11-28
申请号：US18628304
申请日：2024-04-05
Applicant: BioNTech SE
Inventor： Ugur Sahin , Gábor Boros , Azita Josefine Mahiny , Jonas Reinholz , Katalin Karikó
IPC: A61K48/00 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/215 , A61P31/14 , A61P35/00 , B82Y5/00 , C12N7/00 , C12N15/11 , C12N15/67 , C12N15/88 , C12P19/34
Abstract: Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
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69.发明公开公开(公告)号：US20240158501A1
公开(公告)日：2024-05-16
申请号：US18468103
申请日：2023-09-15
Applicant: BioNTech SE , Astellas Pharma Inc.
Inventor： Ugur Sahin , Christiane Stadler , Leyla Fischer , Arne Jendretzki , Özlem Türeci , Fabrice Le Gall , Maria Kreuzberg
CPC classification number: C07K16/2809 , A61P35/00 , C07K16/28 , C12N15/86 , A61K2039/505 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73
Abstract: The present invention provides binding agents comprising at least three binding domains, wherein a first binding domain binds to a T cell-specific antigen and a second binding domain and a third binding domain bind to a claudin, and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.
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公开(公告)号：US11951185B2
公开(公告)日：2024-04-09
申请号：US17565921
申请日：2021-12-30
Applicant: BioNTech SE
Inventor： Ugur Sahin , Gábor Boros , Azita Josefine Mahiny , Jonas Reinholz , Katalin Karikó
IPC: A61K48/00 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K39/00 , A61K39/12 , A61K39/215 , A61P31/14 , A61P35/00 , B82Y5/00 , C12N7/00 , C12N15/11 , C12N15/67 , C12N15/88 , C12P19/34 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/0019 , A61K9/1271 , A61K9/5123 , A61K9/5146 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K39/0011 , A61K39/12 , A61K39/215 , A61K48/0033 , A61P31/14 , A61P35/00 , B82Y5/00 , C12N7/00 , C12N15/11 , C12N15/67 , C12N15/88 , C12P19/34 , A61K38/00 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , C12N2770/18022 , C12N2770/18034 , C12N2770/18071 , C12N2770/20034 , C12N2840/00
Abstract: Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
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