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公开(公告)号：US07001759B1
公开(公告)日：2006-02-21
申请号：US09359975
申请日：1999-07-23
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
IPC: A61K31/167 , C12N15/63 , C12N15/87 , C07H21/04
CPC classification number: A61K39/21 , A61K39/00 , A61K39/0011 , A61K39/0225 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/55516 , C12N15/63 , C12N2730/10134 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/20134 , C12N2770/24234 , Y02A50/464 , Y02A90/26 , Y10S514/818
Abstract: Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Abstract translation: 公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及一种缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受病原体的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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公开(公告)号：US20060001087A1
公开(公告)日：2006-01-05
申请号：US10884236
申请日：2004-07-02
Applicant: Bin Wang
Inventor： Bin Wang
IPC: H01L29/76
CPC classification number: H01L29/4983 , H01L29/4916 , H01L29/7835
Abstract: A native high-voltage n-channel LDMOSFET includes a p− doped substrate, a first n+ doped region disposed in the p− doped substrate, a source terminal coupled to the first n+ doped region, an n− well disposed in the substrate, a second n+ doped region disposed in the n− well, a drain terminal coupled to the second n+ doped region, a p+ doped region disposed in the substrate, a body terminal coupled to the p+ doped region, a dielectric layer disposed over the p− doped substrate and a portion of the n− well, a first trench disposed in the n− well, the trench filled with a dielectric material that is in contact with the dielectric layer, a second trench disposed at least partially in the n− well, the second trench filled with a dielectric material and isolating the second n+ region from the p+ region, and a gate partially or fully reversely doped with p+ implant (or an equivalent technique) and disposed over the dielectric layer and a portion of the first trench.
Abstract translation: 原生高压n沟道LDMOSFET包括p掺杂衬底，设置在p掺杂衬底中的第一n +掺杂区，耦合到第一n +掺杂区的源极，设置在衬底中的n阱， 设置在n阱中的第二n +掺杂区域，耦合到第二n +掺杂区域的漏极端子，设置在衬底中的p +掺杂区域，耦合到p +掺杂区域的主体端子，设置在p掺杂区域上的介电层 衬底和n阱的一部分，设置在n阱中的第一沟槽，填充有与介电层接触的电介质材料的沟槽，至少部分地设置在n阱中的第二沟槽， 填充有电介质材料并且将第二n +区域与p +区域隔离的第二沟槽和部分地或完全地反向掺杂有p +注入（或等效技术）并且设置在电介质层和第一沟槽的一部分上的栅极。
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公开(公告)号：US20050236666A1
公开(公告)日：2005-10-27
申请号：US10884326
申请日：2004-07-02
Applicant: Bin Wang
Inventor： Bin Wang
IPC: H01L29/06 , H01L29/10 , H01L29/423 , H01L29/76 , H01L29/78
CPC classification number: H01L29/7835 , H01L29/0653 , H01L29/1045 , H01L29/42368
Abstract: A high-voltage graded junction LDMOSFET includes a substrate of a first conductivity type, a well of the first conductivity type disposed in the substrate, a first region of a second conductivity type disposed in the well of the first conductivity type, a source terminal coupled to the first region of the second conductivity type, a well of the second conductivity type disposed in the substrate, a second region of the second conductivity type disposed in the well of the second conductivity type, a drain terminal coupled to the second region of the second conductivity type, a region of the first conductivity type disposed in the substrate, a body terminal coupled to the region of the first conductivity type, a graded-junction region formed of material of the first conductivity type separating the well of the first conductivity type and the well of the second conductivity type, the material of the first conductivity type in the graded-junction region doped at least an order of magnitude less than the wells, a dielectric layer disposed over the well of the first conductivity type, the graded-junction region and a portion of the well of the second conductivity type, a first isolator disposed in the well of the second conductivity type, the isolator including a dielectric material that is in contact with the dielectric layer, a second isolator disposed at least partially in the well of the second conductivity type, the second isolator including a dielectric material and isolating the second region of the second conductivity type from the region of the first conductivity type, and a gate disposed over the dielectric layer and a portion of the first isolator.
Abstract translation: 高压梯度结LDMOSFET包括第一导电类型的衬底，设置在衬底中的第一导电类型的阱，设置在第一导电类型的阱中的第二导电类型的第一区域，源极端子耦合 到第二导电类型的第一区域，设置在基板中的第二导电类型的阱，设置在第二导电类型的阱中的第二导电类型的第二区域，耦合到第二导电类型的第二区域的漏极端子 第二导电类型，设置在基板中的第一导电类型的区域，耦合到第一导电类型的区域的主体端子，由第一导电类型的材料形成的分级接合区域，该第一导电类型的材料将第一导电类型的阱 和第二导电类型的阱，掺杂了至少一个数量级的渐变结区域中的第一导电类型的材料 小于所述阱的介质层，设置在所述第一导电类型的阱中的介电层，所述渐变接合区域和所述第二导电类型的阱的一部分，设置在所述第二导电类型的阱中的第一隔离器，所述隔离器 包括与电介质层接触的电介质材料，至少部分地设置在第二导电类型的阱中的第二隔离器，第二隔离器包括电介质材料，并将第二导电类型的第二区域与 第一导电类型和设置在电介质层上的栅极和第一隔离器的一部分。
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公开(公告)号：US06468982B1
公开(公告)日：2002-10-22
申请号：US08880576
申请日：1997-06-23
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
IPC: A61K4800
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A90/26 , Y10S435/975 , Y10S514/818
Abstract: Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Abstract translation: 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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公开(公告)号：US5830876A
公开(公告)日：1998-11-03
申请号：US453349
申请日：1995-05-30
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
Abstract: A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is injected with bupivacaine along with DNA in an expressible form, the DNA encoding an antigen. The encoded antigen can be from a protein from the pathogen or from a protein associated with the hyperproliferative disease.
Abstract translation: 公开了免疫个体对病原体的方法。 还公开了治疗具有过度增殖性疾病的个体或治疗被病原体感染的个体的方法。 具体地说，个体以可表达形式的DNA注射布比卡因，编码抗原的DNA。 编码的抗原可以来自病原体的蛋白质或来自与过度增殖性疾病相关的蛋白质。
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Patent Agency Ranking
公开(公告)号：US5593972A
公开(公告)日：1997-01-14
申请号：US125012
申请日：1993-09-21
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
Abstract: Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Abstract translation: 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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公开(公告)号：USD1039353S1
公开(公告)日：2024-08-20
申请号：US29782500
申请日：2021-05-07
Abstract: FIG. 1 is a perspective view of a magnet showing our new design;
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a left side elevation view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken line showing of a magnet is for the purpose of illustrating portions of the article and forms no part of the claimed design. -
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