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公开(公告)号：US06270755B1
公开(公告)日：2001-08-07
申请号：US09541268
申请日：2000-04-03
IPC分类号： A61K3174
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K31/415 , A61K2300/00
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译： 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
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公开(公告)号：US06197513B1
公开(公告)日：2001-03-06
申请号：US09247996
申请日：1999-02-10
申请人： James Coull , Richard Fitzpatrick
发明人： James Coull , Richard Fitzpatrick
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07F9/2408 , C07K1/1077 , C07K14/003
摘要： Disclosed herein are methods for linking a protein or other biomolecule containing a carboxylic acid moiety to a PNA or DNA probe molecule. The methods disclosed herein involve activating the carboxylic acid moiety with an activating agent and reacting the activated carboxylic acid moiety with a PNA or DNA probe having an arylamine or aminooxyacetyl moiety. Conjugates produced by these methods are also disclosed.
摘要翻译： 本文公开了将含有羧酸部分的蛋白质或其它生物分子与PNA或DNA探针分子连接的方法。 本文公开的方法包括用活化剂活化羧酸部分并使活化的羧酸部分与具有芳基胺或氨氧基乙酰部分的PNA或DNA探针反应。 还公开了通过这些方法生产的缀合物。
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公开(公告)号：US20060002889A1
公开(公告)日：2006-01-05
申请号：US11132156
申请日：2005-05-18
申请人： Richard Fitzpatrick
发明人： Richard Fitzpatrick
IPC分类号： A61K31/785 , C08L61/20
CPC分类号： C08G63/6856 , A61K31/785 , A61K31/80 , C08G63/6926 , C08G79/02 , C08G79/04 , C08G79/06 , C09D185/02 , Y02A50/473 , Y02A50/481
摘要： Ionene polymers are effective antipathogenic agents and can be used as a surface treatment or as a pharmaceutical agent. Ionene polymers typically are persistent in an environment because they degrade slowly, however, it is sometimes desirable to have a polymer that degrades over time. Ionene polymers that have one or more hydrolyzable groups in the polymer backbone represent a type of ionene polymer that degrades with time, and the size of the resulting polymer fragments can be controlled by the placement of the hydrolyzable groups.
摘要翻译： 紫罗烯聚合物是有效的抗病原体，可用作表面处理剂或药剂。 紫罗烯聚合物通常在环境中是持久的，因为它们缓慢降解，然而，有时希望具有随时间降解的聚合物。 在聚合物骨架中具有一个或多个可水解基团的紫罗烯聚合物代表随着时间而降解的一类紫罗烯聚合物，并且所得聚合物片段的大小可以通过放置可水解基团来控制。
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64.发明申请公开(公告)号：US20060002888A1
公开(公告)日：2006-01-05
申请号：US11132150
申请日：2005-05-18
IPC分类号： A61K31/785
CPC分类号： A61K31/787 , A61K31/785 , A61K31/80 , Y02A50/473
摘要： A method of using ionene polymers for the treatment or prevention of infections (e.g., pulmonary infections) in cystic fibrosis patients is provided. The method comprises administering to a mammal an effective amount of an ionene polymer to prophylactically or therapeutically treat infections associated with cystic fibrosis.
摘要翻译： 提供了一种使用紫罗烯聚合物治疗或预防囊性纤维化患者感染（如肺部感染）的方法。 该方法包括向哺乳动物施用有效量的紫罗烯聚合物以预防或治疗地治疗与囊性纤维化相关的感染。
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公开(公告)号：US06890523B2
公开(公告)日：2005-05-10
申请号：US10295019
申请日：2002-11-14
IPC分类号： A61K31/78 , A61K31/00 , A61K31/74 , A61K31/795 , A61K38/14 , A61P1/00 , A61P31/00 , A61P31/04 , C08F20/06 , C08F20/54 , C08K5/00 , C08L25/18
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00 , A61K31/415
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译： 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
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公开(公告)号：US06517827B1
公开(公告)日：2003-02-11
申请号：US09901206
申请日：2001-07-09
IPC分类号： A61K3174
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00 , A61K31/415
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译： 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
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公开(公告)号：US20100172861A1
公开(公告)日：2010-07-08
申请号：US12687906
申请日：2010-01-15
IPC分类号： A61K31/795
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00 , A61K31/415
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译： 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
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公开(公告)号：US20060029568A1
公开(公告)日：2006-02-09
申请号：US11102576
申请日：2005-04-07
IPC分类号： A61K31/74
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00 , A61K31/415
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
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公开(公告)号：US20050178807A1
公开(公告)日：2005-08-18
申请号：US10906287
申请日：2005-02-11
申请人： Richard Fitzpatrick
发明人： Richard Fitzpatrick
CPC分类号： A41H31/00
摘要： The disclosed invention is a threader for use with various modular tactical vest systems. The particular modular vest systems have a weaving interface with attachable storage modules. A strap on a module is attached to the threader and the threader is woven through the support web on the vest. As the threader is pulled through the support web, the module is secured to the vest. Two embodiments for attaching the strap to the threader are disclosed.
摘要翻译： 所公开的发明是用于各种模块化战术背心系统的穿线器。 特定的模块化背心系统具有带有可连接存储模块的编织界面。 模块上的皮带连接到穿线器，并且穿线器通过背心上的支撑网被编织。 当穿线器被拉过支撑腹板时，模块固定在背心上。 公开了将带子附接到穿线器的两个实施例。
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公开(公告)号：US06419914B2
公开(公告)日：2002-07-16
申请号：US09878843
申请日：2001-06-11
IPC分类号： A61K3174
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K31/415 , A61K2300/00
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译： 本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法 通过间隔基团与聚合物主链结合。 间隔基可以具有在0至约20个原子范围内的长度。 毒素通常是由病原微生物如细菌分泌的外毒素。
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