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公开(公告)号：US06537973B1
公开(公告)日：2003-03-25
申请号：US10025139
申请日：2001-12-18
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , A61K38/00 , C07H21/00 , C12N9/12 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q1/6876 , C12Q2600/158 , C12Y207/11013
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
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公开(公告)号：US06440739B1
公开(公告)日：2002-08-27
申请号：US09907843
申请日：2001-07-17
申请人： C. Frank Bennett , Susan M. Freier
发明人： C. Frank Bennett , Susan M. Freier
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glioma-associated oncogene-2. Methods of using these compounds for modulation of glioma-associated oncogene-2 expression and for treatment of diseases associated with expression of glioma-associated oncogene-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节胶质瘤相关致癌基因-2的表达。 组合物包含靶向编码胶质瘤相关致癌基因-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节神经胶质瘤相关致癌基因-2表达和治疗与神经胶质瘤相关致癌基因-2表达有关的疾病的方法。
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公开(公告)号：US06426220B1
公开(公告)日：2002-07-30
申请号：US09702327
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
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公开(公告)号：US06372433B1
公开(公告)日：2002-04-16
申请号：US09561497
申请日：2000-04-28
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Inhibitor of DNA binding-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Inhibitor of DNA binding-1. Methods of using these compounds for modulation of Inhibitor of DNA binding-1 expression and for treatment of diseases associated with expression of Inhibitor of DNA binding-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节DNA结合-1的抑制剂的表达。 组合物包含靶向编码DNA结合-1的抑制剂的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节DNA结合-1表达抑制剂和治疗与DNA结合-1抑制剂表达有关的疾病的方法。
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公开(公告)号：US06365354B1
公开(公告)日：2002-04-02
申请号：US09629645
申请日：2000-07-31
申请人： C. Frank Bennett , Jacqueline Wyatt
发明人： C. Frank Bennett , Jacqueline Wyatt
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01005 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Lysophospholipase I. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Lysophospholipase I. Methods of using these compounds for modulation of Lysophospholipase I expression and for treatment of diseases associated with expression of Lysophospholipase I are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节溶血磷脂酶I的表达。组合物包含靶向编码溶血磷脂酶I的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节溶血磷脂酶I表达和治疗疾病的方法 提供与溶血磷脂酶I的表达相关的。
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公开(公告)号：US06335194B1
公开(公告)日：2002-01-01
申请号：US09496694
申请日：2000-02-02
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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公开(公告)号：US06329203B1
公开(公告)日：2001-12-11
申请号：US09657042
申请日：2000-09-08
申请人： C. Frank Bennett , Jacqueline Wyatt
发明人： C. Frank Bennett , Jacqueline Wyatt
IPC分类号： C12N1511
CPC分类号： C12N15/1135 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glioma-associated oncogene-1. Methods of using these compounds for modulation of glioma-associated oncogene-1 expression and for treatment of diseases associated with expression of glioma-associated oncogene-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节胶质瘤相关致癌基因-1的表达。 组合物包含靶向编码胶质瘤相关致癌基因-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节神经胶质瘤相关致癌基因-1表达和治疗与神经胶质瘤相关致癌基因-1表达有关的疾病的方法。
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公开(公告)号：US06265216B1
公开(公告)日：2001-07-24
申请号：US09489868
申请日：2000-01-20
申请人： C. Frank Bennett , Jacqueline Wyatt
发明人： C. Frank Bennett , Jacqueline Wyatt
IPC分类号： A61K317088
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01037 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of cot oncogene. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cot oncogene. Methods of using these compounds for modulation of cot oncogene expression and for treatment of diseases associated with expression of cot oncogene are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节细胞癌基因的表达。 组合物包含靶向编码细胞癌基因的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节婴儿癌基因表达和治疗与癌基因表达相关的疾病的方法。
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公开(公告)号：US06258790B1
公开(公告)日：2001-07-10
申请号：US09377309
申请日：1999-08-19
IPC分类号： C12N500
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of integrin &agr;4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin &agr;4 are preferred. Methods of using these compounds for modulating integrin &agr;4 expression and for treatment of diseases associated with expression of integrin &agr;4 are also provided.
摘要翻译： 提供组合物和方法用于调节整联蛋白α4的表达。 优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整联蛋白α4表达和治疗与整联蛋白α4的表达相关的疾病的方法。
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公开(公告)号：US06200807B1
公开(公告)日：2001-03-13
申请号：US09358683
申请日：1999-07-21
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SHP-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-2. Methods of using these compounds for modulation of SHP-2 expression and for treatment of diseases associated with expression of SHP-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节SHP-2的表达。 组合物包含靶向编码SHP-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节SHP-2表达和治疗与SHP-2表达相关的疾病的方法。
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