摘要:
Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP). In a preferred embodiment, the .beta. amyloid modulator compounds of the invention are comprised of an A.beta. aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural .beta. amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要:
An animal barrier for use in a vehicle is formed by a frame having an opening therein, and partition members mounted to the frame. First and second partition members are spaced apart to define the opening therebetween and are moveable relative to the frame so as to vary the width of the barrier and the width of the opening. A third partition member is slidably mounted to the frame so as to be moveable between a closed position in which it overlies the opening so as to substantially close the opening, and an open position in which is removed from the opening. In the open position, the third partition member may be located to one side of the opening, overlapping one of the first and second partition members or may be located above or below the opening, away from the first and second partition members.
摘要:
Improved methods, systems, graphical user interfaces and computer program code for presenting representations or information concerning digital products are disclosed. The representations of digital products can serve to promote certain digital products at an online digital product distribution site. Information concerning a particular digital product can be rapidly accessible from a displayed page at an online digital product distribution site referencing a plurality of different digital products. According to one aspect, digital product information can be presented in an overlay window that can be initiated by a user and present relevant information concerning a digital product. Advantageously, digital product information can be quickly presented to a user without having to navigate to a new page of an online distribution site.
摘要:
The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要:
In an illustrative embodiment, a computer implemented method for providing remote system recovery services is provided. The computer implemented method generates bootable system recovery images to form a set of bootable system recovery images, creates a list of authorized users from a set of subscribers, and receives a request for a bootable system recovery image, including a subscriber identifier, to form a received request. The computer implemented method further authenticates the subscriber identifier in the received request and sends the bootable system recovery image to the subscriber. Responsive to a determination that the user selected additional services, the computer implemented method performs the selected services.
摘要:
A cathodic protection system comprising remote test units for measuring various voltages and currents at remote locations on a cathodically-protected pipeline. The remote test units may comprise a processor configured to store measurements taken with the voltmeter and a wireless transceiver for communicating with other test units and/or a Web server or host computer in a daisy-chain or mesh radio configuration. The remote test units may comprise an instant-off switch which electrically connects the pipeline with a buried protected coupon of the same material as the pipeline, and a voltmeter configured to measure the instant-off potential of the protected coupon when the switch is opened. The test units may also comprise a millivoltmeter configured to measure a voltage across a critical bond current shunt resistor and an ammeter configured to measure AC and DC current flowing between the pipeline and the protected coupon with the instant-off switch is closed.
摘要:
Apparatuses, methods, and systems for increasing flexibility and/or stretching the muscles of a user generally comprise a user support set atop an enclosure. The enclosure houses mechanisms to actuate a cable system, wherein the mechanisms at least one of feed and retract a cable of the cable system. The apparatuses, methods, and systems also comprise footholds proximate to the user support to support at least the feet from a user, wherein the cable system actuates between the footholds, and wherein the footholds actuate in at least a lateral motion to further accentuate increasing flexibility and/or stretching the muscles. The apparatuses, methods, and systems also comprise a control handle coupled to the cable system for the user to grasp, wherein the cable system actuates to either one of increase and release a tension to the grasped control handle, and wherein the control handle comprises at least one control to regulate the either one of increase and release the tension.
摘要:
A database search system that retrieves multimedia information in a flexible, user friendly system. The search system uses a multimedia database consisting of text, picture, audio and animated data. That database is searched through multiple graphical and textual entry paths. Those entry paths include an idea search, a title finder search, a topic tree search, a picture explorer search, a history timeline search, a world atlas search, a researcher's assistant search, and a feature articles search.
摘要:
A mechanism is provided for scheduling and reserving virtual meeting locations in a calendaring application. Participants use a calendaring application to schedule meetings. If the meeting takes place in a location within the virtual persistent world, then the calendaring application sends the meeting information, including virtual user IDs of the invitees, meeting location, and other virtual world requirements or parameters for the meeting, to a software agent. The software agent receives the meeting information and generates a script for creating the meeting location and a script for destroying the meeting location.