-
公开(公告)号:US07323002B2
公开(公告)日:2008-01-29
申请号:US10603512
申请日:2003-06-25
申请人: Kirk Johnson , Patrick O'Neill
发明人: Kirk Johnson , Patrick O'Neill
IPC分类号: A61M29/00
CPC分类号: A61B17/22031 , A61F2/013
摘要: An emboli extraction catheter and vascular filter system comprising a guidewire, a vascular filter attached near the distal end of the guidewire, and an emboli extraction catheter. The vascular filter has a smaller first diameter for insertion into the lumen of a vessel, and a second larger diameter for expanding to substantially equal the diameter of the lumen and to be placed in generally sealing relationship with the lumen. The emboli extraction catheter is a flexible catheter comprising a hub attached to the proximal end of the catheter. The hub further comprises a sideport and means for maintaining a seal on the guidewire. The emboli extraction catheter can be used to aspirate embolic particulates, so as to avoid their accidental release after they are captured in a vascular filter, and can also be used to empty full vascular filters of embolic particulates which may block distal flow.
摘要翻译: 栓塞提取导管和血管过滤系统,其包括导线,附着在导丝远端附近的血管过滤器和栓塞提取导管。 血管过滤器具有较小的第一直径用于插入容器的内腔,以及第二较大的直径,用于扩张至基本上等于内腔的直径并且与管腔呈大致密封关系。 栓塞提取导管是柔性导管,其包括连接到导管近端的毂。 轮毂还包括侧台和用于在导丝上保持密封的装置。 栓塞提取导管可用于抽吸栓塞颗粒,以避免其在血管过滤器中被捕获后意外释放,也可用于清除堵塞远端血流的栓塞颗粒的全血管过滤器。
-
公开(公告)号:US20070060365A1
公开(公告)日:2007-03-15
申请号:US11225703
申请日:2005-09-12
IPC分类号: A63F9/24
CPC分类号: G07F17/3258 , G07F17/32
摘要: The system provides a control and management solution for linked gaming machines in a progressive game environment. The system can track multiple meters so that multiple progressive jackpots can be maintained for each game and/or for multiple participating business entities sharing in game revenue. Correspondingly, multiple progressive display meters can be controlled for each game machine. The system is scalable from near area progressive systems to wide area progressive systems. In the event that communication is lost with in a wide area progressive environment, one or more game machines may automatically switch to near area progressive behavior until communication is restored. The system is independent of currency and denomination limitations by employing and converting currency as units instead of particular denominations. Game machine population and participation can be remotely managed, updated, and changed from a central management location.
摘要翻译: 该系统为逐步游戏环境中的链接游戏机提供控制和管理解决方案。 该系统可以跟踪多个米,以便可以为每个游戏和/或在游戏收入中共享的多个参与商业实体维护多个累进累积奖金。 相应地,可以为每个游戏机控制多个渐进显示仪表。 该系统可从近区逐步系统扩展到广域逐步系统。 在广域逐步环境中丢失通信的情况下,一个或多个游戏机可以自动切换到近区域逐行行为,直到通信被恢复。 该制度独立于货币和面额限制,采用和转换货币为单位,而不是特定的面额。 游戏机人数和参与可以从中央管理地点进行远程管理,更新和更改。
-
公开(公告)号:US07045519B2
公开(公告)日:2006-05-16
申请号:US09949035
申请日:2001-09-06
申请人: John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
发明人: John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
IPC分类号: A61K31/506 , C07D403/04
CPC分类号: C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
-
公开(公告)号:US20060089369A1
公开(公告)日:2006-04-27
申请号:US11220400
申请日:2005-09-06
申请人: John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
发明人: John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
IPC分类号: A61K31/52 , A61K31/497 , A61K31/4439 , A61K31/506 , C07D473/12 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号: C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
-
公开(公告)号:US20060036763A1
公开(公告)日:2006-02-16
申请号:US11252480
申请日:2005-10-18
申请人: Kirk Johnson , M. Kaashoek
发明人: Kirk Johnson , M. Kaashoek
IPC分类号: G06F15/173
CPC分类号: H04L63/0209 , H04L45/04
摘要: A system and method of routing requests received from client computers. The client computer processor is redirected to a router for which the address is within the preferred coverage zone. If a router is not identified for which the address is within a preferred coverage zone, but a router other than the router that received the request is identified for which the address is within a regular coverage zone, the processor is redirected to the router for which the address is within the regular coverage zone. If a message is transmitted from a router behind a firewall to a router outside the firewall, and then a request for data is received from a processor behind the firewall, the processor is redirected to the address of the router. Routers register themselves dynamically into a hierarchy. In another alternative embodiment, a service request from a particular client computer is serviced immediately by the root router rather than redirected to another router. The root router then attempts to find the best source server for the client computer. The next service request from the client computer is dispatched directly by the root router to this best router.
-
66.
公开(公告)号:US20050282771A1
公开(公告)日:2005-12-22
申请号:US11140504
申请日:2005-05-27
申请人: Kirk Johnson
发明人: Kirk Johnson
IPC分类号: A61K31/717 , A61K31/727 , A61K31/737 , A61K38/48 , A61K45/06
CPC分类号: A61K31/727 , A61K31/731 , A61K31/737 , A61K38/36 , A61K38/37 , A61K38/4846 , A61K45/06 , Y10S514/834 , A61K2300/00
摘要: Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with one another, or with other medications (such as factors VII, VIII and IX) to promote hemostasis. In particular, the use of NASPs in treatment of bleeding disorders, including congenital coagulation disorders, acquired coagulation disorders, and trauma induced hemorrhagic conditions is described.
摘要翻译: 公开了使用非抗凝血硫酸多糖(NASP)作为促凝剂治疗出血性疾病的方法。 NASP可以作为单一药剂或彼此组合施用,或与其它药物(例如因子VII,VIII和IX)一起施用以促进止血。 特别地,描述了使用NASP治疗出血性疾病,包括先天性凝血障碍,获得性凝血障碍和创伤诱导的出血性病症。
-
公开(公告)号:US06656203B2
公开(公告)日:2003-12-02
申请号:US09907860
申请日:2001-07-18
申请人: Noah M. Roth , Kirk Johnson , David J. Wilson , Thomas Wiatrowski
发明人: Noah M. Roth , Kirk Johnson , David J. Wilson , Thomas Wiatrowski
IPC分类号: A61M2900
CPC分类号: A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2230/0093 , A61M25/09 , A61M2025/09183 , A61M2025/09191
摘要: A integral vascular filter system comprising a guidewire and an integral filter which can be used to capture embolic particulates during medical procedures, while allowing for continuous perfusion of blood, with minimal incremental blood flow turbulence. The vascular filter system addresses the clinical problem of minimizing profile or diameter, so as to enable or facilitate the crossing of a lesion or obstruction in the vessel, while also minimizing incremental blood flow turbulence which may result in thrombus formation.
摘要翻译: 整体血管过滤器系统,包括导丝和整体过滤器,其可用于在医疗过程期间捕获栓塞颗粒,同时允许以少量增加的血流湍流连续灌注血液。 血管过滤器系统解决了最小化轮廓或直径的临床问题,以便能够或促进血管中的病变或梗阻的交叉,同时还使可能导致血栓形成的增加的血流湍流最小化。
-
公开(公告)号:US06428559B1
公开(公告)日:2002-08-06
申请号:US09824975
申请日:2001-04-03
申请人: Kirk Johnson
发明人: Kirk Johnson
IPC分类号: A61M2900
CPC分类号: A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要: A removable, variable-diameter vascular filter system comprising a guidewire and a filter which can be used to capture embolic particulates during medical procedures, while allowing for continuous perfusion of blood. The removable, variable-diameter vascular filter system allows the operator to vary the diameter of the filter, so that a single device can be used to capture embolic particulates in vessels with different lumenal diameters.
摘要翻译: 一种可拆卸的可变径血管过滤器系统,包括导丝和过滤器,其可用于在医疗过程中捕获栓塞颗粒,同时允许血液的连续灌注。 可移动的可变直径血管过滤系统允许操作者改变过滤器的直径,使得可以使用单个装置来捕获具有不同管腔直径的容器中的栓塞颗粒。
-
公开(公告)号:US06319896B1
公开(公告)日:2001-11-20
申请号:US09443098
申请日:1999-11-18
申请人: Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人: Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号: A61K3816
CPC分类号: C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
-
公开(公告)号:US6019778A
公开(公告)日:2000-02-01
申请号:US42276
申请日:1998-03-13
申请人: David J. Wilson , Kirk Johnson
发明人: David J. Wilson , Kirk Johnson
摘要: In accordance with the present invention there is provided a delivery apparatus for a self-expanding stent. The apparatus includes an outer sheath, which is an elongated tubular member having distal and proximal ends. The outer sheath is made from an outer polymeric layer, an inner polymeric layer, and a braided reinforcing layer between the inner and outer layers. The reinforcing layer is more rigid than the inner and outer layers. The apparatus further includes an inner shaft located coaxially within the outer sheath. The shaft has a distal end, extending distal to the distal end of the sheath, and a proximal end, extending proximal to the proximal end of the sheath. The shaft further includes a stop attached thereto. The stop is proximal to the distal end of the sheath. Lastly, the apparatus includes a self-expanding stent located within the sheath. The stent makes frictional contact with the inner layer of the sheath. The stent is located between the stop and the distal end of the sheath, with a portion of the shaft disposed coaxially within a lumen of the stent. The stent makes contact with the stop during deployment of the stent.
摘要翻译: 根据本发明,提供了一种用于自扩张支架的输送装置。 该装置包括外护套,其为具有远端和近端的细长管状构件。 外护套由外聚合物层,内聚合物层和内层和外层之间的编织增强层制成。 增强层比内层和外层更刚性。 该装置还包括同轴地位于外护套内的内轴。 轴具有远离护套远端延伸的远端,以及近端延伸至护套近端的近端。 轴还包括附接到其上的止动件。 止挡件靠近护套的远端。 最后,该装置包括位于护套内的自扩张支架。 支架与护套的内层摩擦接触。 支架位于护套的止挡件和远端之间,其中一部分轴同轴地设置在支架的内腔内。 在支架展开期间,支架与止动器接触。
-
-
-
-
-
-
-
-
-