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公开(公告)号：US08263110B2
公开(公告)日：2012-09-11
申请号：US12031656
申请日：2008-02-14
申请人： Glenn T Huang , Thierry Nivaggioli
发明人： Glenn T Huang , Thierry Nivaggioli
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
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62.发明授权公开(公告)号：US08147865B2
公开(公告)日：2012-04-03
申请号：US11474149
申请日：2006-06-23
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译： 生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。 类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。 类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。 或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。
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公开(公告)号：US08048445B2
公开(公告)日：2011-11-01
申请号：US12173746
申请日：2008-07-15
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US08034370B2
公开(公告)日：2011-10-11
申请号：US11931954
申请日：2007-10-31
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US08034366B2
公开(公告)日：2011-10-11
申请号：US11932101
申请日：2007-10-31
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： A61K31/573 , A61F2/14 , A61P27/02
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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66.发明申请RETINOID-CONTAINING SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND RELATED MATTERS 审中-公开包含持续发布的人造植入物及相关事项公开(公告)号：US20110076318A1
公开(公告)日：2011-03-31
申请号：US12962427
申请日：2010-12-07
申请人： Patrick M. Hughes , Orest Olejnik , Glenn Tony Huang , Joan-En Chang-Lin , Thierry Nivaggioli , JaneGuo Shiah , Michele Boix , Christian Sarrazin
发明人： Patrick M. Hughes , Orest Olejnik , Glenn Tony Huang , Joan-En Chang-Lin , Thierry Nivaggioli , JaneGuo Shiah , Michele Boix , Christian Sarrazin
IPC分类号： A61M31/00 , A61K31/4436 , A61P27/02
CPC分类号： A61K31/07 , A61K9/0051 , A61K9/1647 , A61K31/203
摘要： Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.
摘要翻译： 生物相容性眼内植入物包括类视黄醇组分和可生物降解的聚合物，其有效促进类视黄醇组分长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。
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公开(公告)号：US20080286336A1
公开(公告)日：2008-11-20
申请号：US12173746
申请日：2008-07-15
申请人： Jane-Guo SHIAH , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo SHIAH , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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公开(公告)号：US20050244475A1
公开(公告)日：2005-11-03
申请号：US11119001
申请日：2005-04-29
申请人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
发明人： Jeffrey Edelman , Patrick Hughes , Thomas Malone , Gerald DeVries , Joan-En Chang-Lin , Jane Shiah , Thierry Nivaggioli , Lon Spada , Wendy Blanda
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/204 , A61K31/404 , A61K31/454 , A61K31/5377 , A61K47/34
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间的眼睛玻璃体。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症如眼后病症的发生。
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公开(公告)号：US20050244467A1
公开(公告)日：2005-11-03
申请号：US10837355
申请日：2004-04-30
申请人： Thierry Nivaggioli , Jane Shiah , Qing Lin
发明人： Thierry Nivaggioli , Jane Shiah , Qing Lin
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
摘要翻译： 尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。 植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。
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