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271 条记录 (耗时 0.039 秒)

    Delayed onset transdermal delivery device
    61.
    发明授权
    Delayed onset transdermal delivery device 失效
    延迟发作透皮递送装置

    公开(公告)号：US5284660A

    公开(公告)日：1994-02-08

    申请号：US933423

    申请日：1992-08-21

    申请人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    发明人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/70 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61K9/7069 ,  A61K9/7092

    摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.

    摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。 可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

    Control membrane for electrotransport drug delivery
    64.
    发明授权
    Control membrane for electrotransport drug delivery 失效
    电转运药物控制膜

    公开(公告)号：US5169383A

    公开(公告)日：1992-12-08

    申请号：US571577

    申请日：1990-09-07

    申请人： J. Richard Gyory ,  Ronald P. Haak ,  Felix Theeuwes

    发明人： J. Richard Gyory ,  Ronald P. Haak ,  Felix Theeuwes

    IPC分类号： A61J1/20 ,  A61M37/00 ,  A61N20060101 ,  A61N1/30

    CPC分类号： A61N1/0444 ,  A61N1/044

    摘要： A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no electrical current is flowing and yet provides minimal impedance to electrically-assisted agent delivery. The membrane is useful both as a control membrane in an iontophoretic agent delivery device and as a test membrane for testing the performance characteristics of an iontophoretic agent delivery device in vitro.

    摘要翻译： PCT No.PCT / US89 / 04318 Sec。 371 1990年9月7日第 102（e）1990年9月7日PCT PCT 1989年10月2日PCT公布。 出版物WO90 / 0382500 日本1990年04月19日提供了能够控制药剂从离子电渗输送装置中释放的速率的膜。 当没有电流流动时，该膜抑制剂量从输送装置释放，并且对电辅助剂递送提供最小的阻抗。 膜可用作离子电渗剂递送装置中的对照膜以及用于在体外测试离子电渗疗法递送装置的性能特征的测试膜。

    Intravenous system for delivering a beneficial agent
    67.
    发明授权
    Intravenous system for delivering a beneficial agent 失效
    用于递送有益药物的静脉内系统

    公开(公告)号：US5045059A

    公开(公告)日：1991-09-03

    申请号：US568457

    申请日：1990-08-15

    申请人： Felix Theeuwes ,  Su I. Yum

    发明人： Felix Theeuwes ,  Su I. Yum

    IPC分类号： A61M5/14

    CPC分类号： A61M5/1407

    摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.

    摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

    Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance
    69.
    发明授权
    Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance 失效
    用于通过渗透性表面积差异递送有效药物的输送速率控制的静脉内系统

    公开(公告)号：US4969872A

    公开(公告)日：1990-11-13

    申请号：US320732

    申请日：1989-03-08

    申请人： John Urquhart ,  Felix Theeuwes

    发明人： John Urquhart ,  Felix Theeuwes

    IPC分类号： A61M39/00 ,  A61M5/14

    CPC分类号： A61M5/1409

    摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber houses a diffusional or an osmotically driven drug delivery device. The osmotically driven delivery device has a semipermeable, microporous or diffusional wall which surrounds a compartment containing the drug. Drug is delivered through an orifice in the semipermeable/microporous wall or through the diffusional wall itself, into the IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery is controlled by variably adjusting the surface area of the semipermeable/microporous/diffusional wall that is exposed to the IV fluid flowing through the drug formulation chamber.

    摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室容纳扩散或渗透驱动的药物递送装置。 渗透驱动的输送装置具有围绕包含药物的隔室的半透性，微孔或扩散壁。 药物通过半透膜/微孔壁中的孔口或通过扩散壁本身输送到IV液体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 通过可变地调节暴露于流过药物制剂室的IV液体的半透性/微孔/扩散壁的表面积来控制药物递送的速率。