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61.
公开(公告)号:US20030191059A1
公开(公告)日:2003-10-09
申请号:US10223082
申请日:2002-08-16
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Napoleone Ferrara , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Scot A. Marsters , James Pan , Jean-Philippe F. Stephan , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Weilan Ye
IPC: A61K038/17 , C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04 , C12N009/00
CPC classification number: A61K38/17 , C07H21/04 , C07K14/435 , C07K14/47 , C12N5/06 , C12N9/00 , C12P21/02
Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030187215A1
公开(公告)日:2003-10-02
申请号:US10219532
申请日:2002-08-14
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04 , C12N009/00
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030187208A1
公开(公告)日:2003-10-02
申请号:US10219475
申请日:2002-08-13
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030187205A1
公开(公告)日:2003-10-02
申请号:US10219068
申请日:2002-08-13
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030187204A1
公开(公告)日:2003-10-02
申请号:US10219067
申请日:2002-08-14
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030105291A1
公开(公告)日:2003-06-05
申请号:US10227877
申请日:2002-08-26
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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67.
公开(公告)号:US20030105012A1
公开(公告)日:2003-06-05
申请号:US10223088
申请日:2002-08-16
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Napoleone Ferrara , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Scot A. Marsters , James Pan , Jean-Philippe F. Stephan , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Weilan Ye
IPC: C12P021/02 , C12N005/06 , C07K014/435 , A61K038/17 , C07H021/04 , C12N009/00
CPC classification number: A61K38/17 , C07H21/04 , C07K14/435 , C07K14/47 , C12N5/06 , C12N9/00 , C12P21/02 , Y02A50/473
Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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68.
公开(公告)号:US20030105011A1
公开(公告)日:2003-06-05
申请号:US10223084
申请日:2002-08-16
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Napoleone Ferrara , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Scot A. Marsters , James Pan , Jean-Philippe F. Stephan , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Weilan Ye
IPC: A61K038/17 , C07K014/435 , C12P021/02 , C12N005/06 , C07H021/04 , C12N009/00
CPC classification number: A61K38/17 , C07H21/04 , C07K14/435 , C07K14/47 , C12N5/06 , C12N9/00 , C12P21/02 , Y02A50/473
Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030100730A1
公开(公告)日:2003-05-29
申请号:US10230183
申请日:2002-08-28
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号:US20030100718A1
公开(公告)日:2003-05-29
申请号:US10219467
申请日:2002-08-13
Applicant: Genentech, Inc.
Inventor: Kevin P. Baker , Luc Desnoyers , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean-Philippe F. Stephan , Colin K. Watanabe , William I. Wood
IPC: C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC classification number: C07K14/705 , C07K14/47 , G01N33/574
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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