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73 条记录 (耗时 0.047 秒)

    Use Of 5-Alkyl-6-Phenylalkyl-7-Aminoazolopyrimidines, Novel Azolopyrimidines, Processes For Their Preparation And Compositions Comprising Them
    61.
    发明申请
    Use Of 5-Alkyl-6-Phenylalkyl-7-Aminoazolopyrimidines, Novel Azolopyrimidines, Processes For Their Preparation And Compositions Comprising Them 审中-公开
    5-烷基-6-苯基烷基-7-氨基偶氮嘧啶，新型二唑嘧啶，其制备方法及其组合物的应用

    公开(公告)号：US20080188494A1

    公开(公告)日：2008-08-07

    申请号：US11912335

    申请日：2006-04-24

    申请人： Jochen Dietz ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bernd Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler

    发明人： Jochen Dietz ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bernd Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler

    IPC分类号： A01N43/90 ,  C07D487/04 ,  A01P3/00

    CPC分类号： A01N43/90 ,  C07D487/04

    摘要： The use of 5-alkyl-6-phenylalkyl-7-aminoazolopyrimidines of the formula I in which the variables are as defined below: Y is alkylene, alkenylene or alkynylene, optionally substituted by alkyl groups; R1 is halogen, cyano, nitro, hydroxyl, mercapto, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, alkylthio, NRARB, alkylcarbonyl, phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle which contains one to four heteroatoms from the group consisting of O, N and S; RA, RB is hydrogen, alkyl or alkylcarbonyl; n is zero, 1, 2, 3 or 4; R2 is alkyl, alkenyl, cycloalkyl, alkoxyalkyl or alkylthioalkyl; R3 is hydrogen, halogen, cyano, NRARB, hydroxyl, mercapto, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, cycloalkoxy, cycloalkylthio, carboxyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, phenyl, phenoxy, phenylthio, benzyloxy, benzylthio, alkyl-S(O)m—; m is 0, 1 or 2; A is N or C—Ra; Ra is hydrogen or alkyl; where the carbon atoms in Y, R1, R2, R3 and Ra may be substituted according to the description; for controlling phytopathogenic harmful fungi; novel 5-alkyl-6-phenylalkyl-7-amino-azolopyrimidines, processes for their preparation and compositions comprising them.

    摘要翻译： 使用式I的5-烷基-6-苯基烷基-7-氨基偶氮嘧啶，其中变量如下所定义：Y是任选被烷基取代的亚烷基，亚烯基或亚炔基; R 1是卤素，氰基，硝基，羟基，巯基，烷基，卤代烷基，烯基，环烷基，环烯基，烷氧基，卤代烷氧基，烯氧基，炔氧基，烷硫基，NR 或含有一至四个由O，N和S组成的组的杂原子的五元或六元饱和的部分不饱和或芳族杂环; R A，B B是氢，烷基或烷基羰基; n为零，1,2,3或4; R 2是烷基，烯基，环烷基，烷氧基烷基或烷硫基烷基; R 3是氢，卤素，氰基，NR B，B，羟基，巯基，烷基，卤代烷基，环烷基，烷氧基，烷硫基，环烷氧基 烷氧基羰基，烷氧羰基，烷氧基羰基，苯氧基，苯硫基，苄氧基，苄硫基，烷基-S（O）m - m为0,1或2; A是N或C-R a a R a是氢或烷基; 其中Y，R 1，R 2，R 3和R a中的碳原子可以根据 描述; 用于控制植物病原性有害真菌; 新的5-烷基-6-苯基烷基-7-氨基 - 偶氮嘧啶，其制备方法和包含它们的组合物。

    2-Substituted 7-Aminoazolopyrimidines, Processes For Their Preparation And Their Use For Controlling Harmful Fungi, And Compositions Comprising These Compounds
    69.
    发明申请
    2-Substituted 7-Aminoazolopyrimidines, Processes For Their Preparation And Their Use For Controlling Harmful Fungi, And Compositions Comprising These Compounds 审中-公开
    2-取代的7-氨基偶氮嘧啶，其制备方法及其用于控制​​有害真菌和包含这些化合物的组合物

    公开(公告)号：US20080139581A1

    公开(公告)日：2008-06-12

    申请号：US11885536

    申请日：2006-03-02

    申请人： Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bern Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Anja Schwogler ,  Michael Rack

    发明人： Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bern Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Anja Schwogler ,  Michael Rack

    IPC分类号： A01N43/90 ,  A01P3/00 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： 2-Substituted 7-aminoazolopyrimidines of the formula I in which the substituents are as defined below: R1 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkoxyalkyl, benzyloxyalkyl, alkoxyalkenyl or alkoxyalkynyl; R2 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkoxyalkyl and alkylthioalkyl, where the carbon chains in R1 and/or R2 may be substituted according to the description; R3 is halogen, cyano, NRARB, hydroxyl, mercapto, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, cycloalkoxy, cycloalkylthio, carboxyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, phenyl, phenoxy, phenylthio, benzyloxy, benzylthio, alkyl-S(O)m—; A is N and CRx; Rx is hydrogen or one of the groups mentioned under R3; processes and intermediates for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.

    摘要翻译： 2-取代的式I的7-氨基偶氮嘧啶，其中取代基如下：R 1是氢，卤素，氰基，烷基，卤代烷基，烯基，炔基，环烷基，烷氧基，烷氧基烷基，苄氧基烷基 ，烷氧基烯基或烷氧基炔基; R 2是氢，卤素，氰基，烷基，卤代烷基，烯基，炔基，环烷基，烷氧基，烷氧基烷基和烷硫基烷基，其中R 1和/或R 2可以根据描述代替; R 3是卤素，氰基，NR B，B，羟基，巯基，烷基，卤代烷基，环烷基，烷氧基，烷硫基，环烷氧基，环烷硫基 ，羧基，甲酰基，烷基羰基，烷氧基羰基，烯氧基羰基，炔氧基羰基，苯基，苯氧基，苯硫基，苄氧基，苄硫基，烷基-S（O） A是N和CR R x是氢或R 3中提到的基团之一; 制备这些化合物的方法和中间体，包含它们的组合物及其用于控制​​植物病原性有害真菌的用途。

    Substituted 5-Phenyl Pyrimidines I In Therapy
    70.
    发明申请
    Substituted 5-Phenyl Pyrimidines I In Therapy 审中-公开

    公开(公告)号：US20080146593A1

    公开(公告)日：2008-06-19

    申请号：US11815042

    申请日：2006-01-30

    申请人： Joachim Rheinheimer ,  Thomas Grote ,  Bernd Muller ,  Barbara Nave ,  Frank Schieweck ,  Anja Schwogler ,  Thorsten Jabs ,  Carsten Blettner

    发明人： Joachim Rheinheimer ,  Thomas Grote ,  Bernd Muller ,  Barbara Nave ,  Frank Schieweck ,  Anja Schwogler ,  Thorsten Jabs ,  Carsten Blettner

    IPC分类号： A61K31/505 ,  A61K31/513 ,  A61P35/00

    CPC分类号： C07D239/48 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

    摘要： The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR1R2, OR1a or SR1a, in which R1, R2, independently of each other, denote hydrogen, C1-C10-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals Ra1; or the radical NR1R2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR1R2, in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C1-C4-alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals Ra1 as defined in claim 1, R1a has one of the meanings given for R1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C3-C4-alkenyloxy, C3-C4-alkynyloxy, C1-C6-alkylthio, di-(C1-C6-alkyl)amino or C1-C6-alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C1-C2-alkoxy or C1-C4-alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.