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公开(公告)号：US07129326B2
公开(公告)日：2006-10-31
申请号：US10303331
申请日：2002-11-25
CPC分类号： C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound peptide complex; separating the target-bound peptide complex from peptides which do not bind to the target, and identifying the target-bound peptides. In one embodiment the target is skin or hair. In another embodiment the anti-target is hair when the target is skin, and the anti-target is skin when the target is hair.
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公开(公告)号：USD492262S1
公开(公告)日：2004-06-29
申请号：US29191743
申请日：2003-10-14
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公开(公告)号：US09120840B2
公开(公告)日：2015-09-01
申请号：US12751794
申请日：2010-03-31
CPC分类号： C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound peptide complex; separating the target-bound peptide complex from peptides which do not bind to the target, and identifying the target-bound peptides. In one embodiment the target is skin or hair. In another embodiment the anti-target is hair when the target is skin, and the anti-target is skin when the target is hair.
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公开(公告)号：US09084734B2
公开(公告)日：2015-07-21
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/02 , A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或毛发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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公开(公告)号：US08714566B2
公开(公告)日：2014-05-06
申请号：US13224445
申请日：2011-09-02
IPC分类号： B23B31/165 , B23B31/16
CPC分类号： B23B31/16045 , B23B31/1238 , B23B2231/14 , B23B2231/38 , B23B2260/122 , Y10T279/17632 , Y10T279/21 , Y10T408/21
摘要： A power tool constructed in accordance to one example of the present teachings can include a housing having a handle and body portion. A motor can be disposed in the body portion and a drive spindle drivingly connected to the motor. A chuck can comprise a chuck spindle that supports a plurality of chuck jaws. A first sleeve can rotationally communicate with the chuck jaws to move the chuck jaws between a clamping position and a non-clamping position. An indicator mechanism can be disposed on the chuck having a first and second visual indicator. The indicator mechanism can move from a first position to a second position upon rotation of the first sleeve to a location that corresponds to a predetermined clamping force attained by the chuck jaws.
摘要翻译： 根据本教导的一个示例构造的动力工具可以包括具有手柄和主体部分的壳体。 电动机可以设置在主体部分中，驱动轴驱动地连接到电动机。 卡盘可以包括支撑多个卡盘爪的卡盘心轴。 第一套筒可以与卡盘爪旋转地连通，以使卡盘爪在夹紧位置和非夹紧位置之间移动。 可以在具有第一和第二视觉指示器的卡盘上设置指示器机构。 当第一套筒旋转到对应于由卡盘爪获得的预定夹紧力的位置时，指示器机构可以从第一位置移动到第二位置。
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66.发明授权公开(公告)号：US08519861B2
公开(公告)日：2013-08-27
申请号：US12886153
申请日：2010-09-20
IPC分类号： G08B21/00
CPC分类号： B25F1/02 , G02B6/0011
摘要： A tool system with a mount configured to be removably coupled to a surface.
摘要翻译： 具有安装件的工具系统，其被构造成可移除地联接到表面。
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公开(公告)号：USD684070S1
公开(公告)日：2013-06-11
申请号：US29415079
申请日：2012-03-07
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公开(公告)号：US20130065829A1
公开(公告)日：2013-03-14
申请号：US13609116
申请日：2012-09-10
IPC分类号： C07K14/415 , A61P17/00 , A61K38/16
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein is BBI.
摘要翻译： 本发明提供用于治疗增殖性疾病的肽和负载肽。 在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白是BBI。
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公开(公告)号：US08302320B2
公开(公告)日：2012-11-06
申请号：US13181874
申请日：2011-07-13
IPC分类号： G01C9/26
摘要： A tool assembly that includes a tool, which has a frame and a pair of suction cups. Each suction cup has a cup housing and a cup structure. The cup housing is coupled to the frame. The cup structure is at least partly received in the cup housing. At least one of the cup structures is rotatable relative to the frame. A method for releasably securing a tool assembly to a wall is also provided.
摘要翻译： 一种工具组件，其包括具有框架和一对吸盘的工具。 每个吸盘都有一个杯子外壳和一个杯子结构。 杯子壳体联接到框架。 杯结构至少部分地容纳在杯壳中。 杯结构中的至少一个可相对于框架旋转。 还提供了一种用于将工具组件可释放地固定到墙壁上的方法。
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公开(公告)号：US20120110864A1
公开(公告)日：2012-05-10
申请号：US13181874
申请日：2011-07-13
IPC分类号： G01C9/02
摘要： A tool assembly that includes a tool, which has a frame and a pair of suction cups. Each suction cup has a cup housing and a cup structure. The cup housing is coupled to the frame. The cup structure is at least partly received in the cup housing. At least one of the cup structures is rotatable relative to the frame. A method for releasably securing a tool assembly to a wall is also provided.
摘要翻译： 一种工具组件，其包括具有框架和一对吸盘的工具。 每个吸盘都有一个杯子外壳和一个杯子结构。 杯子壳体联接到框架。 杯结构至少部分地容纳在杯壳中。 杯结构中的至少一个可相对于框架旋转。 还提供了一种用于将工具组件可释放地固定到墙壁上的方法。
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