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公开(公告)号：US07421347B2
公开(公告)日：2008-09-02
申请号：US11075231
申请日：2005-03-07
申请人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
发明人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
CPC分类号： C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
摘要： “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
摘要翻译： 提供了“计算机”核酸重组方法，利用遗传算子和利用计算机混洗方法制作的图书馆的相关综合系统。
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62.发明授权公开(公告)号：US07058515B1
公开(公告)日：2006-06-06
申请号：US09539486
申请日：2000-03-30
申请人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
发明人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC分类号： C12N15/11 , B01J2219/00689 , C12N15/1031
摘要： “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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公开(公告)号：US06376246B1
公开(公告)日：2002-04-23
申请号：US09408392
申请日：1999-09-28
申请人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C12N1500
CPC分类号： C12N15/11 , A61K39/00 , B01J2219/00689 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1031 , C12N15/1034 , C12N2740/16122
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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公开(公告)号：US06368861B1
公开(公告)日：2002-04-09
申请号：US09484850
申请日：2000-01-18
申请人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C12N1500
CPC分类号： C12N15/11 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N2740/16122
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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公开(公告)号：US06319714B1
公开(公告)日：2001-11-20
申请号：US09626929
申请日：2000-07-27
申请人： Andreas Crameri , Willem P.C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P.C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C12N1500
CPC分类号： C12N15/11 , A61K39/00 , B01J2219/00689 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1031 , C12N15/1034 , C12N2740/16122
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
摘要翻译： 提供重组核酸的方法，包括同源核酸。 还提供了基因改组寡核苷酸家族及其在重组过程中的应用，以及聚合酶和连接酶介导的重组方法。
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66.发明授权Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedures 有权用于鉴定用于体外重组程序的寡核苷酸组的方法公开(公告)号：US07904249B2
公开(公告)日：2011-03-08
申请号：US11982405
申请日：2007-10-31
申请人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
发明人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
摘要： In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination. In certain embodiments, the methods involve inputting amino acid sequence character strings into a digital system and back-translating the amino acid character strings into a plurality of nucleic acid character strings. The nucleic acid character strings are then processed to define and select at least one recombinant nucleic acid for use in identifying one or more oligonucleotides for in vitro recombination.
摘要翻译： 在计算机核酸重组方法中，利用遗传算子的相关综合系统用于鉴定用于体外重组的寡核苷酸组。 在某些实施方案中，所述方法包括将氨基酸序列字符串输入到数字系统中，并将氨基酸字符串逆向翻译成多个核酸字符串。 然后处理核酸字符串以限定和选择至少一种用于鉴定用于体外重组的一种或多种寡核苷酸的重组核酸。
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67.发明授权公开(公告)号：US07024312B1
公开(公告)日：2006-04-04
申请号：US09618579
申请日：2000-07-18
申请人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
发明人： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
摘要： “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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公开(公告)号：US06479652B1
公开(公告)日：2002-11-12
申请号：US09626595
申请日：2000-07-27
申请人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C07H2102
CPC分类号： C12N15/11 , A61K39/00 , B01J2219/00689 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1031 , C12N15/1034 , C12N2740/16122
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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公开(公告)号：US06423542B1
公开(公告)日：2002-07-23
申请号：US09626930
申请日：2000-07-27
申请人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C12N1500
CPC分类号： C12N15/11 , A61K39/00 , B01J2219/00689 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1031 , C12N15/1034 , C12N2740/16122
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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70.发明申请公开(公告)号：US20060205003A1
公开(公告)日：2006-09-14
申请号：US11429628
申请日：2006-05-05
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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