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公开(公告)号：US06316024B1
公开(公告)日：2001-11-13
申请号：US09517224
申请日：2000-03-02
IPC分类号： A61K9127
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US6056973A
公开(公告)日：2000-05-02
申请号：US138480
申请日：1998-08-21
CPC分类号： A61K9/1271 , A61K47/48053 , A61K47/4823 , A61K47/48238 , A61K47/48561 , A61K47/48815 , A61K47/48823 , A61K51/1234 , A61K9/127 , A61K9/1272 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US5631018A
公开(公告)日：1997-05-20
申请号：US317723
申请日：1994-10-04
IPC分类号： A61K9/127 , A61K47/32 , A61K47/34 , A61K47/48 , C08F289/00 , C08G69/10 , C08G69/48 , C08G73/02 , C08G73/10 , C08G81/02
CPC分类号： A61K9/1271 , Y10T428/2984
摘要： A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.
摘要翻译： 公开了用于形成长循环脂质体的脂质 - 聚合物缀合物。 缀合物包括与其极性头基共价连接的囊泡形成脂质，聚合物之一：聚乙烯吡咯烷酮，聚乙烯基甲基醚，聚羟基丙基甲基丙烯酸酯，聚羟基丙基甲基丙烯酰胺，聚羟基乙基丙烯酸酯，聚甲基丙烯酰胺，聚二甲基丙烯酰胺，聚甲基恶唑啉，聚乙基恶唑啉，聚羟乙基唑啉，聚羟基丙基恶唑啉或聚天冬酰胺。 还公开了一种制备含有脂质 - 聚合物缀合物的脂质体的方法。
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公开(公告)号：US5545698A
公开(公告)日：1996-08-13
申请号：US150414
申请日：1993-11-10
摘要： The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.
摘要翻译： 本发明涉及聚乙二醇（PEG）衍生化的接枝载体，制备这些载体的方法以及使用载体通过固相合成技术合成肽的方法。 本发明的PEG-接枝载体包括共价连接到固体载体如聚苯乙烯的官能化PEG衍生物。
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公开(公告)号：US5235028A
公开(公告)日：1993-08-10
申请号：US760768
申请日：1991-09-16
摘要： The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.
摘要翻译： 本发明涉及聚乙二醇（PEG）衍生化的接枝载体，制备这些载体的方法以及使用载体通过固相合成技术合成肽的方法。 本发明的PEG-接枝载体包括共价连接到固体载体如聚苯乙烯的官能化PEG衍生物。
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