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公开(公告)号：US07122202B2
公开(公告)日：2006-10-17
申请号：US09876707
申请日：2001-06-07
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US06316024B1
公开(公告)日：2001-11-13
申请号：US09517224
申请日：2000-03-02
IPC分类号： A61K9127
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US6056973A
公开(公告)日：2000-05-02
申请号：US138480
申请日：1998-08-21
CPC分类号： A61K9/1271 , A61K47/48053 , A61K47/4823 , A61K47/48238 , A61K47/48561 , A61K47/48815 , A61K47/48823 , A61K51/1234 , A61K9/127 , A61K9/1272 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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公开(公告)号：US06043094A
公开(公告)日：2000-03-28
申请号：US949039
申请日：1997-10-10
IPC分类号： A61K9/127 , A61K31/715 , A61K38/00 , A61K47/30 , A61P29/00 , A61P35/00 , C12N5/02 , C12N15/64
CPC分类号： A61K9/1273 , A61K9/1271
摘要： A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.
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公开(公告)号：US5972379A
公开(公告)日：1999-10-26
申请号：US054857
申请日：1998-04-02
IPC分类号： A61K9/00 , A61K9/127 , A61K31/47 , A61K31/495 , A61K31/496 , A61K41/00 , A61K47/48 , A61P31/04
CPC分类号： A61K9/1278 , A61K41/0038 , A61K47/48038 , A61K47/48046 , A61K9/1271
摘要： A liposome composition for treating a bacterial infection is described. The composition includes liposomes having a surface coating of hydrophilic polymer chains and an entrapped drug-conjugate composed of ciprofloxacin conjugated to an amino acid.
摘要翻译： 描述了用于治疗细菌感染的脂质体组合物。 该组合物包括具有亲水性聚合物链的表面包被的脂质体和与氨基酸缀合的环丙沙星组成的截留的药物缀合物。
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公开(公告)号：US06586002B2
公开(公告)日：2003-07-01
申请号：US09877978
申请日：2001-06-08
IPC分类号： A61K9127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译： 公开了包含小的表面结合效应分子的脂质体组合物。 脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。 效应分子连接到聚合物链的末端。 在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。
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公开(公告)号：US5534259A
公开(公告)日：1996-07-09
申请号：US89086
申请日：1993-07-08
申请人： Samuel Zalipsky , Francis J. Martin
发明人： Samuel Zalipsky , Francis J. Martin
CPC分类号： A61K9/1271 , A61K9/1273
摘要： A composition of polymer-coated particles, and a polymer compound used in forming the particles are disclosed. The polymer compound is composed of a hydrophilic polymer attached to a lipophilic moiety through a linking segment which contains chemical groups through which the compound can be crosslinked to other such compounds. The particles in the composition are prepared by forming lipid structures containing ordered arrays of the polymer compounds, and crosslinking the compounds through their chemical groups. The particles are used for parenteral administration of a pharmaceutical compound which is entrapped in the particles.
摘要翻译： 公开了聚合物涂覆颗粒的组合物和用于形成颗粒的聚合物化合物。 高分子化合物由亲水性部分组成，该亲水性聚合物通过连接部分连接，该连接部分含有化学基团，通过该化学基团，化合物可以与其他这样的化合物交联。 组合物中的颗粒通过形成含有聚合物化合物的有序阵列的脂质结构并通过化学基团交联化合物来制备。 颗粒用于胃肠外给药被包埋在颗粒中的药物化合物。
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公开(公告)号：US5395619A
公开(公告)日：1995-03-07
申请号：US25602
申请日：1993-03-03
IPC分类号： A61K9/127 , A61K47/32 , A61K47/34 , A61K47/48 , C08F289/00 , C08G69/10 , C08G69/48 , C08G73/02 , C08G73/10 , C08G81/02
CPC分类号： A61K9/1271 , Y10T428/2984
摘要： A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.
摘要翻译： 公开了用于形成长循环脂质体的脂质 - 聚合物缀合物。 缀合物包括与其极性头基共价连接的囊泡形成脂质，聚合物之一：聚乙烯吡咯烷酮，聚乙烯基甲基醚，聚羟基丙基甲基丙烯酸酯，聚羟基丙基甲基丙烯酰胺，聚羟基乙基丙烯酸酯，聚甲基丙烯酰胺，聚二甲基丙烯酰胺，聚甲基恶唑啉，聚乙基恶唑啉，聚羟乙基唑啉，聚羟基丙基恶唑啉或聚天冬酰胺。 还公开了一种制备含有脂质 - 聚合物缀合物的脂质体的方法。
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公开(公告)号：US07160554B2
公开(公告)日：2007-01-09
申请号：US10438502
申请日：2003-05-14
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译： 公开了包含小的表面结合效应分子的脂质体组合物。 脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。 效应分子连接到聚合物链的末端。 在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。
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公开(公告)号：US07150882B2
公开(公告)日：2006-12-19
申请号：US10832636
申请日：2004-04-26
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
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