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    MULTI-SPOT INVESTIGATION APPARATUS
    61.
    发明申请
    MULTI-SPOT INVESTIGATION APPARATUS 审中-公开
    多点调查装置

    公开(公告)号：US20100051788A1

    公开(公告)日：2010-03-04

    申请号：US11721392

    申请日：2005-12-13

    申请人： Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Menno Prins

    发明人： Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Menno Prins

    IPC分类号： G01J1/58 ,  H01J40/02 ,  G01N21/00

    CPC分类号： G01N21/645 ,  B01L3/5085 ,  G01N21/6452 ,  G01N2201/0635

    摘要： The invention relates to a method and an apparatus for the investigation of a sample material that is stored in the sample chamber (303) of a storage unit (300). A multi-spot generator MSG (100) and a transmission section (200) generate an array of sample light spots (501) within the sample chamber. Input light (504) that leaves the storage unit (300) in forward direction is mapped onto a CCD array (401) and measured as reference. Moreover, fluorescence light (500) that is stimulated in the sample chamber (303) is measured by a second CCD array which is disposed perpendicular to the optical path of the input light (504).

    摘要翻译： 本发明涉及一种用于研究存储在存储单元（300）的样品室（303）中的样品材料的方法和装置。 多点发生器MSG（100）和透射部分（200）在样品室内产生样品光点阵列（501）。 将存储单元（300）向前移动的输入光（504）映射到CCD阵列（401）上并作为参考进行测量。 此外，通过垂直于输入光（504）的光路设置的第二CCD阵列来测量在样品室（303）中被刺激的荧光（500）。

    Imaging Apparatus for Combined Temperature and Luminescence Spatial Imaging of an Object
    62.
    发明申请
    Imaging Apparatus for Combined Temperature and Luminescence Spatial Imaging of an Object 审中-公开
    用于物体的组合温度和发光空间成像的成像装置

    公开(公告)号：US20090194693A1

    公开(公告)日：2009-08-06

    申请号：US12301642

    申请日：2007-05-14

    申请人： Derk Jan Wilfred Klunder ,  Aleksey Kolesnychenko

    发明人： Derk Jan Wilfred Klunder ,  Aleksey Kolesnychenko

    IPC分类号： G01N21/64 ,  G01N21/76

    CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/76

    摘要： An imaging apparatus is disclosed for combined temperature and luminescence spatial imaging of an object (1), such as a bio-array for detection of biological molecules. Light (5) is separated into a first (10) and a second (20) optical path, where the first optical path (10) guides infrared (IR), and the second optical path (20) guides luminescence light, preferably fluorescence light, from the object (1). Image intensifying means (30) converts infrared light (10a) in the first optical path into intensified light (10b), preferably visible light. Photo detection means (100) are arranged for spatial imaging of the object (1), the photo detection means being arranged for alternately receiving light from the first (10) and the second (20) optical path. Processing means (200) are capable of combining a temperature image (11) with a luminescence image (21) so as to obtain a combined image (25) of the object with a direct spatial correspondence between the two images. For bio-arrays this provides many advantages in relation to combined imaging of an array, whereupon numerous probe molecules are located.

    摘要翻译： 公开了用于物体（1）的组合温度和发光空间成像的成像装置，例如用于检测生物分子的生物阵列。 光（5）被分离为第一光路（10）和第二光路（20），其中第一光路（10）引导红外（IR），第二光路（20）引导发光，优选荧光 ，从对象（1）。 图像增强装置（30）将第一光路中的红外光（10a）转换成强光（10b），优选可见光。 照片检测装置（100）布置成用于物体（1）的空间成像，光检测装置被布置成交替地接收来自第一光（10）和第（20）光路的光。 处理装置（200）能够将温度图像（11）与发光图像（21）组合，从而以两个图像之间的直接空间对应来获得对象的组合图像（25）。 对于生物阵列，这提供了与阵列的组合成像相关的许多优点，因此存在许多探针分子。

    EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES
    63.
    发明申请
    EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES 审中-公开
    评估光学不均匀性的测定

    公开(公告)号：US20140051187A1

    公开(公告)日：2014-02-20

    申请号：US14113964

    申请日：2012-04-23

    申请人： Toon Hendrik Evers ,  Derk Jan Wilfred Klunder ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adianus Dionisius Van Zon

    发明人： Toon Hendrik Evers ,  Derk Jan Wilfred Klunder ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adianus Dionisius Van Zon

    IPC分类号： G01N21/00

    摘要： The invention relates to a method and a sensor device (100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest(ROI) may be rejected.

    摘要翻译： 本发明涉及用于评价样品的测定方法和传感器装置（100）。 在测定期间，在感测表面（112）处进行光学测量，并且产生感测表面（112）的至少一个“均匀性图像”。 从该图像中，对于至少一个感兴趣的区域确定“均匀度指标”，然后根据所述指标来评估光学测量。 均匀度指示符可以例如是二进制值，其指示是否检测到不均匀性。 如果检测到不均匀性，则所有光学测量可能被拒绝，只有感兴趣区域的测量可能被拒绝，或者所涉及的感兴趣区域（ROI）的选定子区域的测量可能被拒绝。

    Luminescence sensor operating in reflection mode
    65.
    发明授权
    Luminescence sensor operating in reflection mode 有权
    发光传感器以反射模式工作

    公开(公告)号：US08039814B2

    公开(公告)日：2011-10-18

    申请号：US12158451

    申请日：2006-12-19

    申请人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    发明人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  G01N21/6428

    摘要： A luminescence sensor, such as a luminescence biosensor or a luminescence chemical sensor, includes a substrate having at least one aperture filled with a medium. The aperture has a first lateral dimension larger than the diffraction limit of excitation radiation in the medium, and a second lateral dimension smaller than the diffraction limit of the excitation radiation in the medium. A method is also provided for the detection of luminescence radiation, e.g. fluorescence radiation, generated by at least one optically variable molecule, e.g. fluorophore, in the at least one aperture. Beneficially, the excitation radiation is polarized to suppress the excitation radiation in the apertures. The luminescence sensor and the method are able to detect relatively low concentrations of optically variable molecules, e.g. fluorophores.

    摘要翻译： 诸如发光生物传感器或发光化学传感器的发光传感器包括具有填充有介质的至少一个孔的基板。 该孔具有比介质中的激发辐射的衍射极限大的第一横向尺寸，以及小于介质中的激发辐射的衍射极限的第二横向尺寸。 还提供了一种用于检测发光辐射的方法，例如， 由至少一个光学可变分子产生的荧光辐射，例如。 荧光团，在至少一个孔中。 有利地，激发辐射被极化以抑制孔中的激发辐射。 发光传感器和方法能够检测相对低浓度的光学可变分子，例如， 荧光团

    Luminescence sensor using multi-layer substrate structure
    67.
    发明授权
    Luminescence sensor using multi-layer substrate structure 有权
    发光传感器采用多层衬底结构

    公开(公告)号：US07560708B2

    公开(公告)日：2009-07-14

    申请号：US11995696

    申请日：2006-07-07

    申请人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder

    发明人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder

    IPC分类号： G01J1/58

    CPC分类号： G01N21/76 ,  G01N21/648 ,  G01N33/54306 ,  G01N33/582

    摘要： The present invention provides a luminescence sensor (2), such as e.g. a luminescence biosensor, comprising a multi-layer structure. The multi-layer structure comprises at least a first layer (2a) formed of a first material and a second layer (2b) formed of a second material. The first material has a first binding capacity towards luminophores and the second material has a second binding capacity towards luminophores, the first binding capacity being different from the second binding capacity. The luminescence sensor (2) according to the present invention shows a high sensitivity because it provides preferred binding sites for luminophores at locations where the combined excitation and detection efficiency is the highest.

    摘要翻译： 本发明提供一种发光传感器（2），例如， 发光生物传感器，包括多层结构。 多层结构至少包括由第一材料形成的第一层（2a）和由第二材料形成的第二层（2b）。 第一材料具有朝向发光体的第一结合能力，第二材料具有朝向发光体的第二结合能力，第一结合能力不同于第二结合能力。 根据本发明的发光传感器（2）显示出高灵敏度，因为它在组合的激发和检测效率最高的位置处为发光体提供优选的结合位点。

    Luminescence Sensor Operating in Reflection Mode
    68.
    发明申请
    Luminescence Sensor Operating in Reflection Mode 有权
    发光传感器在反射模式下工作

    公开(公告)号：US20080272313A1

    公开(公告)日：2008-11-06

    申请号：US12158451

    申请日：2006-12-19

    申请人： Maarten Marinus Johannes Wilhemus Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    发明人： Maarten Marinus Johannes Wilhemus Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  G01N21/6428

    摘要： The present invention relates to a luminescence sensor (10), such as a luminescence biosensor or a luminescence chemical sensor, comprising at least one aperture (1) having a first lateral dimension larger than the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with and a second lateral dimension below the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with. The invention furthermore relates to a method for the detection of luminescence radiation (5), e.g. fluorescence radiation, generated by at least one optically variable molecule (2), e.g. fluorophore, in the at least one aperture (1). The excitation radiation (3) is preferably polarised to suppress the excitation radiation (3) in the apertures (1). The luminescence sensor (10) according to the present invention is able to detect relatively low concentrations of optically variable molecules (2), e.g. fluorophores.

    摘要翻译： 本发明涉及一种发光传感器（10），例如发光生物传感器或发光化学传感器，其包括至少一个孔（1），其具有比介质中的激发辐射（3）的衍射极限大的第一横向尺寸 所述至少一个孔（1）在所述至少一个孔（1）填充的介质中填充有低于激发辐射（3）的衍射极限的第二横向尺寸。 本发明还涉及用于检测发光辐射（5）的方法，例如， 由至少一个光学可变分子（2）产生的荧光辐射，例如。 在所述至少一个孔（1）中的荧光团。 激发辐射（3）优选地被极化以抑制孔（1）中的激发辐射（3）。 根据本发明的发光传感器（10）能够检测相对低浓度的光学可变分子（2），例如， 荧光团

    Optical system for mapping signal light onto a detector
    70.
    发明授权
    Optical system for mapping signal light onto a detector 失效
    用于将信号光映射到检测器上的光学系统

    公开(公告)号：US07947946B2

    公开(公告)日：2011-05-24

    申请号：US11909638

    申请日：2006-03-27

    申请人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    发明人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    IPC分类号： G01D5/36

    CPC分类号： G01N21/645 ,  G02B27/0037 ,  G02B27/4205 ,  G02B27/4277

    摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.

    摘要翻译： 本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。 通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。 为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。 光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。