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公开(公告)号：US12044623B2
公开(公告)日：2024-07-23
申请号：US17584469
申请日：2022-01-26
Inventor： Holger Schmidt , Aaron Roe Hawkins , Joshua Wayne Parks
CPC classification number: G01N21/645 , B01L3/502715 , G02B6/12007 , G02F1/217 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , G01N2021/6417 , G01N2021/6419 , G01N2021/6484 , G01N2201/0635 , G01N2201/088 , G02B6/2813
Abstract: Systems, methods, and techniques for optofluidic analyte detection and analysis using multi-mode interference (MMI) waveguides are disclosed herein. In some embodiments, spatially and spectrally multiplexed optical detection of particles is implemented on an optofluidic platform comprising multiple analyte channels intersecting a single MMI waveguide. In some embodiments, multi-stage photonic structures including a first stage MMI waveguide for demultiplexing optical signals by spatially separating different wavelengths of light from one another may be implemented. In some embodiments, a second stage may use single-mode waveguides and/or MMI waveguides to create multi-spot patterns using the demultiplexed, spatially separated light output from the first stage. In some embodiments, liquid-core MMI (LC-MMI) waveguides that are tunable by replacing a liquid core, heating/cooling the liquid core, and/or deforming the LC-MMI to change its width may be implemented in one or more of the analyte detection/analysis systems disclosed herein.
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公开(公告)号：US11892438B2
公开(公告)日：2024-02-06
申请号：US17115792
申请日：2020-12-09
Applicant: Asahi Kasei Microdevices Corporation
Inventor： Takaaki Furuya , Tatsushi Yagi , Toshiro Sakamoto
CPC classification number: G01N33/0027 , G01N21/552 , G01N21/5907 , G02B6/122 , G02B6/12002 , G02B6/124 , G02B6/4215 , G01N2201/0635 , G01N2201/08
Abstract: Provided is an optical densitometer for measuring a density of a gas or liquid of interest, the optical densitometer comprising: a light source capable of introducing light into a core layer; a detector capable of receiving the light that has propagated through the core layer; and an optical waveguide, the optical waveguide comprising: a substrate; and the core layer comprising a light propagation portion capable of propagating the light in an extending direction of the light propagation portion, and a diffraction grating portion, the diffraction grating portion comprising a diffraction grating region and an extension region connected to the diffraction grating region, and a first optical coupling region included in the extension region and a second optical coupling region included in the light propagation portion being optically coupled with respect to the light propagating through the core layer.
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公开(公告)号：US20230204515A1
公开(公告)日：2023-06-29
申请号：US18087341
申请日：2022-12-22
Applicant: HORIBA INSTRUMENTS INCORPORATED
Inventor： Nicolas VEZARD , Beth FINAMORE , Aashish TULADHAR
CPC classification number: G01N21/65 , G01N21/6428 , G01N2201/06113 , G01N2201/0633 , G01N2201/0636 , G01N2201/08 , G01N2201/0635 , G01N2201/127
Abstract: A microplate reader simultaneously obtains Raman measurements from samples contained in non-adjacent wells. At least two Raman probes are positioned perpendicularly above or below the microplate to simultaneously acquire Raman spectra data of the non-adjacent liquid samples. Each probe is coupled to a laser and a spectrometer and includes a lens focusing laser light within the sample and collecting light from the sample for the spectrometer. The spectrometer may include a 2D imaging sensor (sCMOS or CCD) to image light from multiple probes simultaneously, spaced from one another to reduce crosstalk. A positioner moves the microplate plate or probes to acquire data from a different subset of non-adjacent samples, and may also vary laser focus within wells during data acquisition. Multiple fluorescence probes may simultaneously acquire fluorescence data from the same samples, or non-adjacent samples. Probes may be fiber-coupled and positioned within a reaction chamber of a liquid handling system.
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公开(公告)号：US11656172B1
公开(公告)日：2023-05-23
申请号：US17335921
申请日：2021-06-01
Applicant: Photonics Automation Specialties LLC
Inventor： Gerard Knight-Rubino , Xiyao Zhang
IPC: G01N21/31
CPC classification number: G01N21/31 , G01N2201/0635 , G01N2201/0638 , G01N2201/08
Abstract: A multichannel angular spectrometer includes an array of fiber pickups having an arcuate arrangement and focused about a sample volume. A broadband light source is configured to illuminate a sample within the sample volume. At least one dispersion element is in optical communication with the array of fiber pickups. An imaging sensor is in optical communication with the array of fiber pickups. The imaging sensor is configured to image the broadband light received by the array of fiber pickups and dispersed by the at least one dispersion element. A processor is in electrical communication with the imaging sensor. The processor has a power supply and computer-readable memory.
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公开(公告)号：US20180180545A1
公开(公告)日：2018-06-28
申请号：US15739435
申请日：2016-06-10
Applicant: KONICA MINOLTA, INC.
Inventor： SHINICHI MURAMATSU , KEIZOU TAKANO
IPC: G01N21/64 , G01N21/552 , G01N33/553
CPC classification number: G01N21/6428 , G01N21/554 , G01N21/64 , G01N21/645 , G01N33/543 , G01N33/553 , G01N2021/6439 , G01N2021/6463 , G01N2201/0635 , G01N2333/8139
Abstract: Provided is a measurement method with which an analyte in a sample containing a high concentration of the analyte can be measured with high accuracy without diluting the sample in multiple stages. An embodiment of the present invention relates to a measurement method for measuring an amount of an analyte in a sample, the method including: a binding step of providing the sample to a containing part of a measuring chip including the containing part for containing liquid, and a first capture body immobilized inside the containing part and having a recognition site that specifically binds to the analyte so as to bind the analyte contained in the sample to the first capture body; and a measurement step of measuring an amount of the analyte bound to the first capture body. The measurement method includes an adjustment step in which a second capture body having a recognition site that specifically binds to the analyte is bound to a part of the analyte in the sample in parallel with the binding step or before the binding step so as to reduce the amount of the analyte capable of binding to the first capture body.
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Patent Agency Ranking
公开(公告)号：US09912121B2
公开(公告)日：2018-03-06
申请号：US15149595
申请日：2016-05-09
Applicant: Palo Alto Research Center Incorporated
Inventor： Thomas Wunderer , Christopher L. Chua , Brent S. Krusor , Noble M. Johnson
CPC classification number: H01S5/18363 , B82Y20/00 , G01N21/17 , G01N21/41 , G01N2201/0635 , G01N2201/08 , G02B5/0816 , G02B5/085 , H01S5/18308 , H01S5/18341 , H01S5/18369 , H01S5/18377 , H01S5/34333 , H01S2304/04
Abstract: A device includes one or more reflector components. Each reflector component comprises layer pairs of epitaxially grown reflective layers and layers of a non-epitaxial material, such as air. Vias extend through at least some of the layers of the reflector components. The device may include a light emitting layer.
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公开(公告)号：US09823195B2
公开(公告)日：2017-11-21
申请号：US13748508
申请日：2013-01-23
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Mark F. Oldham , Eugene F. Young
CPC classification number: G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
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公开(公告)号：US20170329122A1
公开(公告)日：2017-11-16
申请号：US15666842
申请日：2017-08-02
Applicant: NIKON CORPORATION
Inventor： Hisao OSAWA
CPC classification number: G02B21/365 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N2021/6439 , G01N2021/6478 , G01N2201/0612 , G01N2201/062 , G01N2201/0635 , G02B21/06 , G02B21/10 , G02B21/125 , G02B21/16 , G02B21/367 , G02B27/58
Abstract: A structured illumination microscope includes: a first illumination optical system configured to irradiate, from a first direction, a sample with activating light for activating a fluorescent substance included in the sample; a second illumination optical system configured to irradiate, from a second direction that is different from the first direction, the sample with interference fringes of exciting light for exciting the fluorescent substance; a control unit configured to control a direction and a phase of the interference fringes; an imaging optical system configured to form an image of the sample irradiated with the interference fringes; an imaging element configured to take the image formed by the imaging optical system to generate a first image; and a demodulation unit configured to generate a second image by using a plurality of the first images generated by the imaging element.
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公开(公告)号：US20170276614A1
公开(公告)日：2017-09-28
申请号：US15082327
申请日：2016-03-28
Applicant: Saudi Arabian Oil Company
Inventor： Enrico Bovero , Abdullah S. Al-Ghamdi , Abdullah A. Al-Shahrani
CPC classification number: G01N21/8851 , G01B11/165 , G01L1/00 , G01N21/4788 , G01N2201/0635 , G02B5/1861 , G02B27/4244
Abstract: Systems and methods are disclosed relating to composite photonic materials used to design structures and detecting material deformation for the purpose of monitoring structural health of physical structures. According to one aspect, a composite structure is provided that includes a base material, an optical diffraction grating and one or more fluorophore materials constructed such that localized perturbations create a measurable change in the structure's diffraction pattern. An inspection device is also provided that is configured to detect perturbations in the composite structure. The inspection device is configured to emit an inspecting radiation into the structure and capture the refracted radiation and measure the change in the diffraction pattern and quantify the perturbation based on the wavelength and the angular information for the diffracted radiation.
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公开(公告)号：US20170146458A1
公开(公告)日：2017-05-25
申请号：US15316568
申请日：2015-06-03
Applicant: Ludwig-Maximilians-Universität München
Inventor： Robert Alexander Huber , Sebastian Karpf , Matthias Eibl
CPC classification number: G01N21/6456 , G01J3/0218 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6408 , G01N21/65 , G01N2021/6484 , G01N2201/06146 , G01N2201/0635 , G01N2201/105 , G01N2201/11 , G01N2201/12 , H01S3/06712 , H01S3/06754 , H01S3/094007 , H01S3/10015 , H01S3/1618 , H01S3/2316 , H01S3/302 , H01S2301/02
Abstract: Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.
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