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61.发明申请Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权新型二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20080281092A1
公开(公告)日：2008-11-13
申请号：US12219196
申请日：2008-07-17
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
IPC分类号： C07D205/04
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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62.发明申请1,3-SUBSTITUTED CYCLOALKYL DERIVATIVES HAVING ACIDIC, MOSTLY HETEROCYCLIC GROUPS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS 有权具有酸性，多数杂环基团的1,3-取代环己基衍生物，其制备方法及其作为药物的用途公开(公告)号：US20080249126A1
公开(公告)日：2008-10-09
申请号：US11775564
申请日：2007-07-10
申请人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： A61K31/437 , C07D263/30 , A61K31/421 , A61P3/10 , A61P3/00 , C07D471/02
CPC分类号： C07D263/32 , C07D413/12 , C07D471/04 , C07F5/025
摘要： The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved.
摘要翻译： 本发明涉及具有酸性，主要是杂环基团的1,3-取代的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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63.发明授权Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权酸基取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07388004B2
公开(公告)日：2008-06-17
申请号：US11643890
申请日：2006-12-22
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07F9/568 , A61K31/397 , A61P9/10 , A61P3/06
CPC分类号： C07D205/08
摘要： One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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64.发明授权Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07335671B2
公开(公告)日：2008-02-26
申请号：US10789017
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/4439 , A61K31/422 , C07D413/02
CPC分类号： C07D263/32 , C07D413/02
摘要： Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticalsThe invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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65.发明申请NOVEL FLUOROGLYCOSIDE DERIVATIVES OF PYRAZOLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF 有权吡咯烷酮的新型荧光素衍生物，含有这些化合物的药物及其用途公开(公告)号：US20070197623A1
公开(公告)日：2007-08-23
申请号：US11567410
申请日：2006-12-06
申请人： Harm BRUMMERHOP , Wendelin Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
发明人： Harm BRUMMERHOP , Wendelin Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
IPC分类号： A61K31/4155 , C07D231/12
CPC分类号： C07H17/02
摘要： The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method for their production, and to their use as antidiabetics.
摘要翻译： 本发明涉及在说明书中进一步定义的式（I）的吡唑的取代的氟代糖苷衍生物与其生理上相容的盐，其生产方法及其作为抗糖尿病药物的用途。
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66.发明申请2-{-3,'2-(PHENYL)-OXAZOL-4-YLMETHOXYL-CYCLOHEXYL METHOXY}-PROPIONIC ACID DERIVATIVES USED AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权用于治疗高脂血症和糖尿病的过氧化物酶促反应激活受体（PPAR）配体的2-（-3 - ， - 2-（苯基） - 唑-4-基甲氧基 - 环己基甲氧基} - 丙酸衍生物公开(公告)号：US20070197613A1
公开(公告)日：2007-08-23
申请号：US11671673
申请日：2007-02-06
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： C07D263/30 , A61K31/421
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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67.发明申请2-{-3-'2-(PHENYL)-OXAZOL-4-YLMETHOXYMETHYL-CYCLOHEXYLMETHOXY}-PROPIONIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权2 - { - 3 - {2-（苯基） - 唑-4-基甲氧基甲基 - 环己基甲基}乙酸衍生物作为过氧化物酶促活化受体（PPAR）配体用于治疗高磷脂酰胆碱和糖尿病公开(公告)号：US20070197612A1
公开(公告)日：2007-08-23
申请号：US11670594
申请日：2007-02-02
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/421 , C07D263/34
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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68.发明申请ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权ARYLCYCLOAKYL-替代的酸性衍生物有效用作治疗高脂血症和糖尿病的过氧化物促进剂激活受体（PPAR）配体公开(公告)号：US20070197605A1
公开(公告)日：2007-08-23
申请号：US11672302
申请日：2007-02-07
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/4439 , A61K31/422 , C07D413/02
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with arylcycloalkyl-substituted alkanoic acid derivatives and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及含有芳基环烷基取代的链烷酸衍生物的乙酸衍生物的血液中诸如高脂血症，糖尿病，胰岛素抵抗等的胰岛素相关代谢紊乱，以及 他们的盐 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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69.发明申请Novel Thiophene Glycoside Derivatives, Processes for The Preparation, Medicaments Comprising These Compounds, and The Use Thereof 有权新型噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US20060293252A1
公开(公告)日：2006-12-28
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
IPC分类号： A61K31/7052 , C07H17/02
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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70.发明申请Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof 有权新型芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途公开(公告)号：US20050014704A1
公开(公告)日：2005-01-20
申请号：US10735179
申请日：2003-12-12
申请人： Wendelin Frick , Heiner Glombik , Werner Kramer , Hurbert Heuer , Harm Brummerhop , Oliver Plettenburg
发明人： Wendelin Frick , Heiner Glombik , Werner Kramer , Hurbert Heuer , Harm Brummerhop , Oliver Plettenburg
IPC分类号： A61K31/70 , A61K31/7048 , A61K31/7052 , A61P3/10 , C07H15/203 , C07H17/02
CPC分类号： C07H15/203
摘要： Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 新型芳香族氟代糖苷衍生物，含有这些化合物的药物及其用途。 本发明涉及其中基团具有所述含义的式I的取代芳族氟代糖苷衍生物及其生理学耐受盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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