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61.
公开(公告)号:US20050014739A1
公开(公告)日:2005-01-20
申请号:US10847123
申请日:2004-05-17
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer
IPC分类号: C07D417/12 , A61K31/397 , C07D205/08
CPC分类号: C07D417/12
摘要: The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph.
摘要翻译: 本发明涉及氨曲南的β多晶型物,其含有小于2.5%(重量)的残留溶剂和制备所述多晶型物的方法。
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62.
公开(公告)号:US07619112B2
公开(公告)日:2009-11-17
申请号:US11893216
申请日:2007-08-14
申请人: Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人: Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号: C07C55/00
CPC分类号: C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
摘要翻译: 本发明涉及纯(R)-CMH和涉及(S)-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化(R)-CMH的方法和从母液中分离(S)-CMH的方法。
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公开(公告)号:US20090137821A1
公开(公告)日:2009-05-28
申请号:US12317438
申请日:2008-12-22
申请人: Laszlo Zsolt Kovacs , Csaba Szabo , Erika Magyar Molnarne , Adrienne Kovacsne-Mezei , Claude Singer , Judith Aronhime
发明人: Laszlo Zsolt Kovacs , Csaba Szabo , Erika Magyar Molnarne , Adrienne Kovacsne-Mezei , Claude Singer , Judith Aronhime
IPC分类号: C07D335/04
CPC分类号: C07D495/04
摘要: Processes for the preparation of dorzolamide hydrochloride and an intermediate of Formula IV, are provided.
摘要翻译: 提供了制备盐酸多佐胺和式IV中间体的方法。
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公开(公告)号:US20090042839A1
公开(公告)日:2009-02-12
申请号:US12152830
申请日:2008-05-15
IPC分类号: A61K31/663 , C07F9/28 , A61P19/00
CPC分类号: C07F9/3873
摘要: Provided are crystalline forms of ibandronate sodium, as well as processes for the preparation thereof.
摘要翻译: 提供了伊班膦酸钠的结晶形式,以及其制备方法。
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公开(公告)号:US20080139808A1
公开(公告)日:2008-06-12
申请号:US12012183
申请日:2008-01-30
申请人: Nissim Garti , Yana Berkovich , Ben-Zion Dolitzky , Judith Aronhime , Claude Singer , Anita Liebermann , Neomi Gershon
发明人: Nissim Garti , Yana Berkovich , Ben-Zion Dolitzky , Judith Aronhime , Claude Singer , Anita Liebermann , Neomi Gershon
IPC分类号: C07D253/075
CPC分类号: C07D253/075
摘要: The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.
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66.
公开(公告)号:US07358093B2
公开(公告)日:2008-04-15
申请号:US11723867
申请日:2007-03-22
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号: G01N33/15 , G01N21/94 , C07D205/085
CPC分类号: C07D417/12 , C07C229/26 , Y10T436/145555
摘要: The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译: 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
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67.Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process 失效
标题翻译: 纯化N- [3-(3-氰基吡唑并[1,5-a]嘧啶-7-基)苯基] -N-乙基乙酰胺(zaleplon)的方法和可通过该方法获得的扎来普隆的结晶形式公开(公告)号:US07348429B2
公开(公告)日:2008-03-25
申请号:US10952151
申请日:2004-09-27
申请人: Erika Feher , Ferenc Korodi , Claude Singer , Erika Magyar
发明人: Erika Feher , Ferenc Korodi , Claude Singer , Erika Magyar
IPC分类号: C07D487/04 , A61K31/519 , G01N33/15
CPC分类号: C07D487/04 , Y10T436/147777
摘要: Provided are novel Zaleplon crystalline Forms II, III, IV and V, which are useful for the treatment of insomnia. Also provided are processes for making Forms I, II, and V using precipitation methods.
摘要翻译: 提供了新颖的Zaleplon晶型II,III,IV和V,它们可用于治疗失眠。 还提供了使用沉淀法形成I,II和V的方法。
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公开(公告)号:US20070287860A1
公开(公告)日:2007-12-13
申请号:US11893300
申请日:2007-08-14
申请人: Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人: Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号: C07B57/00
CPC分类号: C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
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69.
公开(公告)号:US20070287859A1
公开(公告)日:2007-12-13
申请号:US11893235
申请日:2007-08-14
申请人: Lilach Hedvati , Dee-Noor Ziv , Claude Singer , Gideon Pilarski
发明人: Lilach Hedvati , Dee-Noor Ziv , Claude Singer , Gideon Pilarski
IPC分类号: C07B57/00
CPC分类号: C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要: The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
摘要翻译: 本发明涉及纯(R)-CMH和涉及(S)-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化(R)-CMH的方法和从母液中分离(S)-CMH的方法。
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70.Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process 审中-公开
标题翻译: 纯化N- [3-(3-氰基吡唑并[1,5-a]嘧啶-7-基)苯基] - 乙基乙酰胺(扎来普仑)的方法和可通过该方法获得的扎来普隆的结晶形式公开(公告)号:US20070238739A1
公开(公告)日:2007-10-11
申请号:US11805163
申请日:2007-05-21
申请人: Erika Feher , Ferenc Korodi , Claude Singer , Erika Magyar
发明人: Erika Feher , Ferenc Korodi , Claude Singer , Erika Magyar
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D487/04
摘要: Provided are novel Zaleplon crystalline Forms II, III, IV and V, which are useful for the treatment of insomnia.
摘要翻译: 提供了新颖的Zaleplon晶型II,III,IV和V,它们可用于治疗失眠。
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