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61.发明授权(Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression 失效（芳基（烷基）羰基） - 杂环化合物及其在治疗焦虑和抑郁中的应用
公开(公告)号：US5534517A
公开(公告)日：1996-07-09
申请号：US296665
申请日：1994-08-26
申请人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , A61K31/495 , A61K31/535
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base. The compounds are useful for treating or preventing anxiety and depression.
摘要翻译： 本发明涉及从式（I）的化合物中选择的化合物：其中Ar，n，B和A如说明书中所定义，与它们的光学异构体及其与 药学上可接受的酸或碱。 该化合物可用于治疗或预防焦虑和抑郁。
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公开(公告)号：US5459138A
公开(公告)日：1995-10-17
申请号：US217192
申请日：1994-03-24
申请人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
发明人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
IPC分类号： A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D513/04
CPC分类号： C07D513/04
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.4 are as defined in the description,and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of glutamatergic neurotransmission.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中A，R 1，R 2和R 4如说明书中所定义，其中含有该化合物的医药产品可用于治疗病理学 与谷氨酸能神经传递功能障碍有关。
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公开(公告)号：US5420150A
公开(公告)日：1995-05-30
申请号：US174187
申请日：1993-12-27
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。 用于治疗抑郁和焦虑的药用产品。
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公开(公告)号：US5389668A
公开(公告)日：1995-02-14
申请号：US180849
申请日：1994-01-12
申请人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
发明人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
IPC分类号： A61K31/38 , A61K31/382 , A61K31/42 , A61K31/435 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/04 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D335/06 , C07D409/12 , C07D413/12 , A61K31/40 , C07D405/00 , C07D409/00
CPC分类号： C07D335/06 , C07D409/12 , C07D413/10 , C07D413/12
摘要： The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, and medicinal products which are useful for treating Central Nervous System disorders.
摘要翻译： 本发明涉及式I化合物：其中R 1如说明书中所定义，它们的光学异构体及其与药学上可接受的酸或碱的加成盐，以及可用于治疗的药用产品 中枢神经系统疾病。
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公开(公告)号：US5382593A
公开(公告)日：1995-01-17
申请号：US94562
申请日：1993-07-20
申请人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Guillaume Le Baut , Marie-Renee Nourrisson , Jean-Francois Renaud de la Faverie , Jean-Guy Bizot Espiard , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/4427 , A61P3/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/08 , C07D209/30 , C07D209/34 , C07D401/04
CPC分类号： C07D401/04 , A61K31/40 , C07D209/30 , C07D209/34
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.
摘要翻译： 本发明涉及选自式（I）的化合物：其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义，其Z和E异构体，其旋光异构体， 其形式为混合物，其与药学上可接受的酸或碱的加成盐，以及含有该药物的药物可用于治疗由二氧化反应现象引起的或与过氧化作用有关的病症，类二十烷酸合成紊乱 ，或血小板聚集障碍。
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公开(公告)号：US5376661A
公开(公告)日：1994-12-27
申请号：US36329
申请日：1993-03-24
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00 , C07D471/20 , A61K31/44
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。 用于治疗抑郁和焦虑的药用产品。
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公开(公告)号：US5332741A
公开(公告)日：1994-07-26
申请号：US62424
申请日：1993-05-17
申请人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
发明人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
IPC分类号： A61K31/38 , A61K31/382 , A61K31/42 , A61K31/435 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/04 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D335/06 , C07D409/12 , C07D413/12 , C07D403/12
CPC分类号： C07D335/06 , C07D409/12 , C07D413/10 , C07D413/12
摘要： The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, andmedicinal products which are useful for treating Central Nervous System disorders.
摘要翻译： 本发明涉及式I化合物：其中R 1如说明书中所定义，它们的光学异构体及其与药学上可接受的酸或碱的加成盐，以及可用于治疗的药用产品 中枢神经系统疾病。
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公开(公告)号：US5242923A
公开(公告)日：1993-09-07
申请号：US839819
申请日：1992-02-21
申请人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
发明人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
IPC分类号： C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： The invention relates to the compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, Z and m are as defined in the description, their isomers, epimers and diastereoisomers,their addition salts with a pharmaceutically acceptable acid and, when R1 and R.sub.2 each represent a hydrogen atom, their addition salts with a pharmaceutically acceptable base.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1，R2，R3，R4，A，Z和m如说明书中所定义，它们的异构体，差向异构体和非对映异构体，其加成盐与 药学上可接受的酸，并且当R 1和R 2各自表示氢原子时，它们与药学上可接受的碱的加成盐。
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公开(公告)号：US5190960A
公开(公告)日：1993-03-02
申请号：US791261
申请日：1991-11-12
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description.
摘要翻译： 通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素 原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义 在说明中。
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公开(公告)号：US5155116A
公开(公告)日：1992-10-13
申请号：US711297
申请日：1991-06-06
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： A61K31/44 , A61P9/00 , A61P25/04 , A61P25/28 , C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description have medicinal properties.
摘要翻译： 通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素 原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义 在说明书中具有药用性质。
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