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公开(公告)号：US5721276A
公开(公告)日：1998-02-24
申请号：US657972
申请日：1996-05-30
申请人： Isabelle Lesieur , Patrick Depreux , Veronique Leclerc , Philippe Delagrange , Pierre Renard , Beatrice Guardiola Lemaitre
发明人： Isabelle Lesieur , Patrick Depreux , Veronique Leclerc , Philippe Delagrange , Pierre Renard , Beatrice Guardiola Lemaitre
IPC分类号： C07D333/60 , A61K31/165 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/405 , A61P3/04 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C235/34 , C07C235/36 , C07D209/18 , C07D307/79 , C07D307/80 , C07D307/92 , C07D311/92 , C07D333/24 , C07C233/05
CPC分类号： C07D307/79 , C07C235/34 , C07C235/36 , C07D209/18 , C07D307/92 , C07D311/92 , C07D333/24 , C07C2101/02 , C07C2101/04 , C07C2101/14
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which A, B, X and R.sub.1 are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中A，B，X和R 1如说明书中所定义，其中含有相同用途的药物产品可用于治疗 褪黑激素系统。
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公开(公告)号：US5420158A
公开(公告)日：1995-05-30
申请号：US035936
申请日：1993-03-23
申请人： Said Yous , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Gerard Adam , Pierre Renard , Daniel H. Caignard
发明人： Said Yous , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Gerard Adam , Pierre Renard , Daniel H. Caignard
IPC分类号： A61K31/135 , A61K31/16 , A61K31/215 , A61P17/00 , A61P25/00 , A61P37/00 , A61P43/00 , C07C233/05 , C07C233/58 , C07C233/60 , C07C233/63 , C07C275/24 , C07D295/10 , A01N1/00 , C07C229/34
CPC分类号： C07C233/63 , C07C233/05 , C07C233/58 , C07C233/60 , C07C275/24 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要： The invention relates to a compound selected from those of general formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable base.Medicinal product which is useful in the treatment of disorders linked to abnormal melatonin activity.
摘要翻译： 本发明涉及选自通式（I）的化合物：其中R，R 1，R 2和R 3如本说明书中所定义的其中R 1，R 2和R 3如本文所定义的光学异构体及其加成盐与药学上 可接受的基地 可用于治疗与异常褪黑素活性相关的疾病的药用产品。
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公开(公告)号：US5371103A
公开(公告)日：1994-12-06
申请号：US133901
申请日：1993-10-12
申请人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
发明人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
IPC分类号： A61K31/38 , A61K31/382 , A61K31/42 , A61K31/435 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/04 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D335/06 , C07D409/12 , C07D413/12 , C07D311/04
CPC分类号： C07D335/06 , C07D409/12 , C07D413/10 , C07D413/12
摘要： The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, andmedicinal products which are useful for treating Central Nervous System disorders.
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4.发明授权
公开(公告)号：US5387586A
公开(公告)日：1995-02-07
申请号：US206451
申请日：1994-03-04
申请人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , A61K31/535 , C07D417/14
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base.Medicinal product which is useful for treating pain and treating or preventing pathologies which require psychotropic agents.
摘要翻译： 本发明涉及从式（I）的化合物中选择的化合物：其中Ar，n，B和A如说明书中所定义，与它们的光学异构体及其与 药学上可接受的酸或碱。 可用于治疗疼痛和治疗或预防需要精神药物的病理学的药用产品。
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公开(公告)号：US5385930A
公开(公告)日：1995-01-31
申请号：US181984
申请日：1994-01-14
申请人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
发明人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
IPC分类号： A61K31/38 , A61K31/382 , A61K31/42 , A61K31/435 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/04 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D335/06 , C07D409/12 , C07D413/12 , A61K31/505 , C07D335/04
CPC分类号： C07D335/06 , C07D409/12 , C07D413/10 , C07D413/12
摘要： The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, and medicinal products which are useful for treating Central Nervous System disorders.
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公开(公告)号：US5693665A
公开(公告)日：1997-12-02
申请号：US584465
申请日：1996-01-10
申请人： Daniel Lesieur , Eric Fourmaintraux , Patrick Depreux , Philippe Delagrange , Pierre Renard , Beatrice Guardiola-Lemaitre
发明人： Daniel Lesieur , Eric Fourmaintraux , Patrick Depreux , Philippe Delagrange , Pierre Renard , Beatrice Guardiola-Lemaitre
IPC分类号： A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61P3/00 , A61P3/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C233/02 , C07C233/05 , C07C233/08 , C07C233/09 , C07C233/58 , C07C273/02 , C07C275/24 , C07C275/26 , C07C303/38 , C07C311/03 , C07C311/10 , C07C311/11 , C07C327/38 , C07C335/12 , C07C335/14 , C07D209/14 , C07D307/81 , C07D333/58 , A61K31/38 , C07D335/06
CPC分类号： C07C233/08 , C07C233/05 , C07C233/58 , C07D307/81 , C07D333/58 , C07C2101/02 , C07C2101/04 , C07C2102/10
摘要： The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melatoninergic disorder.
摘要翻译： 本发明涉及选自这些式（I）的化合物：其中：R 1，R 2，R 3和A如说明书中所定义，和含有可用于治疗褪黑激素的药物 紊乱。
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7.发明授权(Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression 失效（芳基（烷基）羰基） - 杂环化合物及其在治疗焦虑和抑郁中的应用
公开(公告)号：US5534517A
公开(公告)日：1996-07-09
申请号：US296665
申请日：1994-08-26
申请人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , A61K31/495 , A61K31/535
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base. The compounds are useful for treating or preventing anxiety and depression.
摘要翻译： 本发明涉及从式（I）的化合物中选择的化合物：其中Ar，n，B和A如说明书中所定义，与它们的光学异构体及其与 药学上可接受的酸或碱。 该化合物可用于治疗或预防焦虑和抑郁。
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公开(公告)号：US5449690A
公开(公告)日：1995-09-12
申请号：US359605
申请日：1994-12-20
申请人： Daniel Lesieur , Said Yous , Patrick DePreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
发明人： Daniel Lesieur , Said Yous , Patrick DePreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
IPC分类号： A61K31/17 , A61K8/42 , A61K8/46 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P35/00 , A61Q7/00 , A61Q17/00 , A61Q19/00 , C07C273/02 , C07C275/24 , C07C335/12 , C07C335/14
CPC分类号： C07C335/12 , A61K8/42 , A61K8/46 , A61Q19/00 , C07C275/24 , A61Q17/00 , A61Q7/00 , C07C2101/02 , C07C2101/14 , Y10S514/923
摘要： A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are as defined in the specification, and medicinal products containing the same which are useful in treating or in preventing a disorder of the melatoninergic system.
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公开(公告)号：US5389683A
公开(公告)日：1995-02-14
申请号：US930285
申请日：1992-08-14
申请人： Daniel Lesieur , Said Yous , Patrick Depreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
发明人： Daniel Lesieur , Said Yous , Patrick Depreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
IPC分类号： A61K31/17 , A61K8/42 , A61K8/46 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P35/00 , A61Q7/00 , A61Q17/00 , A61Q19/00 , C07C273/02 , C07C275/24 , C07C335/12 , C07C335/14 , C07C275/06
CPC分类号： C07C335/12 , A61K8/42 , A61K8/46 , A61Q19/00 , C07C275/24 , A61Q17/00 , A61Q7/00 , C07C2101/02 , C07C2101/14 , Y10S514/923
摘要： A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are as defined in the specification, andmedicinal products containing the same which are in treating or in preventing a disorder of the melatoninergic system.
摘要翻译： 选自式（I）的化合物：其中R，R 1，R 2和X的含义如说明书中所定义的其中的化合物和含有该化合物的药物，其用于治疗或预防 褪黑激素系统紊乱。
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公开(公告)号：US5389668A
公开(公告)日：1995-02-14
申请号：US180849
申请日：1994-01-12
申请人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
发明人： Gerald Guillaumet , Gerard Coudert , Tchao Podona , Beatrice Guardiola-Lemaitre , Pierre Renard , Gerard Adam , Daniel Henri-Caignard
IPC分类号： A61K31/38 , A61K31/382 , A61K31/42 , A61K31/435 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/04 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D335/06 , C07D409/12 , C07D413/12 , A61K31/40 , C07D405/00 , C07D409/00
CPC分类号： C07D335/06 , C07D409/12 , C07D413/10 , C07D413/12
摘要： The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, and medicinal products which are useful for treating Central Nervous System disorders.
摘要翻译： 本发明涉及式I化合物：其中R 1如说明书中所定义，它们的光学异构体及其与药学上可接受的酸或碱的加成盐，以及可用于治疗的药用产品 中枢神经系统疾病。
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