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61.发明申请PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS 审中-公开吡咯并吡啶酮化合物可用于治疗钠通道介导的疾病或病症公开(公告)号：US20080194616A1
公开(公告)日：2008-08-14
申请号：US12026435
申请日：2008-02-05
申请人： Shifeng Liu , Jianmin Fu , Rajender Kamboj , Sultan Chowdhury , Qi Jia , Mark Wood , Jianyu Sun
发明人： Shifeng Liu , Jianmin Fu , Rajender Kamboj , Sultan Chowdhury , Qi Jia , Mark Wood , Jianyu Sun
IPC分类号： A61K31/444 , C07D471/02 , A61P29/00
CPC分类号： C07D471/04
摘要： This invention is directed to pyridopyrimidinone compounds of formula (I): wherein n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及式（I）的吡啶并嘧啶酮化合物：其中n，R 1，R 2和R 3如本文所定义， 作为立体异构体，其对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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62.发明申请公开(公告)号：US20100240713A1
公开(公告)日：2010-09-23
申请号：US12663104
申请日：2008-06-05
申请人： Jean-Jacques Cadieux , Mikhail Chafeev , Julia Fonarev , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Serguei Sviridov , Zaihui Zhang
发明人： Jean-Jacques Cadieux , Mikhail Chafeev , Julia Fonarev , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Serguei Sviridov , Zaihui Zhang
IPC分类号： A61K31/44 , C07C211/50 , C07C261/04 , C07C22/04 , C07C33/26 , C07D333/12 , C07D333/16 , C07D495/02 , C07D249/14 , C07D213/53 , A61K31/135 , A61K31/165 , A61K31/03 , A61K31/047 , A61K31/381 , A61K31/4196 , A61P43/00
CPC分类号： A61K31/155 , A61K31/275 , A61K31/381 , A61K31/4196 , A61K31/44 , Y02A50/411
摘要： This invention is directed to compounds of formula (I), wherein m, formula (II), R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.
摘要翻译： 本发明涉及式（I）化合物，其中m，式（II），R 1，R 2和R 3如本文所定义，为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗铁疾病。 本发明还涉及包含该化合物的药物组合物和使用该化合物治疗铁疾病的方法。
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63.发明授权公开(公告)号：US07829712B2
公开(公告)日：2010-11-09
申请号：US11575642
申请日：2005-09-20
申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Serguei Sviridov , Sultan Chowdhury , Vishnumurthy Kodumuru
发明人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Serguei Sviridov , Sultan Chowdhury , Vishnumurthy Kodumuru
IPC分类号： C07D413/00 , C07D211/30 , C07D401/00 , A61K31/50 , A61K31/497 , A61K31/41 , A61K31/415
CPC分类号： C07D401/12 , A61K31/501 , C07D237/24 , C07D403/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物，其中x，y，G，J，K， L，M，Q，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a。 还公开了包含式（I）化合物的药物组合物。
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64.发明授权Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents 有权哌嗪衍生物作为硬脂酰辅酶A去饱和酶抑制剂及其作为治疗剂的用途公开(公告)号：US08030488B2
公开(公告)日：2011-10-04
申请号：US12247792
申请日：2008-10-08
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： C07D239/02
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R2，R3，R4，R5，R6，R7，R8，R8a，R9，R9a，R10，R10a，R11和R11a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20060252767A1
公开(公告)日：2006-11-09
申请号：US10567009
申请日：2004-07-29
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael Winther , Heins Gschwend , Rajender Kamboj , Shaoyi Sun , Mark Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael Winther , Heins Gschwend , Rajender Kamboj , Shaoyi Sun , Mark Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/497 , C07D403/04
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R 2，R 3，R 4，R 5，R SUP > 6，R 7，R 8，R 8a，R 9，R SUP， > 9a，R 10，R 10a，R 11和R 11a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07456180B2
公开(公告)日：2008-11-25
申请号：US10567009
申请日：2004-07-29
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/497 , C07D241/02
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，y，W，V，R 2，R 3，R 4，R 5，R SUP > 6，R 7，R 8，R 8a，R 9，R SUP， > 9a，R 10，R 10a，R 11和R 11是本文定义的 。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20060293308A1
公开(公告)日：2006-12-28
申请号：US10566857
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A01N43/62
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R R 1，R 2，R 3，R 4，R 5，R 5，R 5， R 6，R 7，R 7，R 8，R 8，R 8， R 9，R 9，R 10和R 10 10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20100029718A1
公开(公告)日：2010-02-04
申请号：US12442279
申请日：2007-09-19
申请人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
发明人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
IPC分类号： A61K31/427 , C07D417/04 , C07D417/14 , A61K31/454 , A61K31/4545 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
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公开(公告)号：US20090030008A1
公开(公告)日：2009-01-29
申请号：US12247792
申请日：2008-10-08
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/496 , C07D403/04 , A61P3/04 , A61P3/10
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R2，R3，R4，R5，R6，R7，R8，R8a，R9，R9a，R10，R10a，R11和R11a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US08236835B2
公开(公告)日：2012-08-07
申请号：US12442279
申请日：2007-09-19
申请人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
发明人： Natalie Dales , Zaihui Zhang , Rajender Kamboj , Jianmin Fu , Shaoyi Sun , Natalia Pokrovskaia , Serguei Sviridov
IPC分类号： A61K31/426
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。
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