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公开(公告)号：US20060293308A1
公开(公告)日：2006-12-28
申请号：US10566857
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel Harvey , Mikhail Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Rodumuru , Michael Winther , Heinz Gschwend , Nagasres Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A01N43/62
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R R 1，R 2，R 3，R 4，R 5，R 5，R 5， R 6，R 7，R 7，R 8，R 8，R 8， R 9，R 9，R 10和R 10 10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20060199802A1
公开(公告)日：2006-09-07
申请号：US10566193
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel Harvey , Heins Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael Winther , Vishnumurthy Kodumuru , Cindy Hudson , Mikhail Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel Harvey , Heins Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael Winther , Vishnumurthy Kodumuru , Cindy Hudson , Mikhail Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/551 , A61K31/496
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (1): wherein: W is —O—, —N(R1)—, C(O), S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R1)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（1）化合物：其中：W是-O - ， - N （R 1） - ，C（O），S（O）t; （其中t为0,1或2），N（R1）S（O）2，S（O）2N（R1），C（O）N（R1）或N（R1）C（O） ）; 并且V是C（O），C（S），C（O）N（R 1） - ，C（O）O-，S（O）2 - ，S（O）2 N（R 1） - 或C ）H; 并且x，y，R1，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20050119251A1
公开(公告)日：2005-06-02
申请号：US10885901
申请日：2004-07-06
申请人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael Winther , Richard Fine , Daniel Harvey , Boris Klebansky , Mark Gray-Keller , Heinz Gschwend , Wenbao Li
发明人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael Winther , Richard Fine , Daniel Harvey , Boris Klebansky , Mark Gray-Keller , Heinz Gschwend , Wenbao Li
IPC分类号： A61K31/496 , A61K31/551
CPC分类号： A61K31/496 , A61K31/551 , Y02A50/387
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中m，n，p，V，R ，R2，R3，R4，R5和R6如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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4.发明申请公开(公告)号：US20080103304A1
公开(公告)日：2008-05-01
申请号：US11969539
申请日：2008-01-04
申请人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
发明人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
IPC分类号： C07D473/00
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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5.发明申请公开(公告)号：US20050267134A1
公开(公告)日：2005-12-01
申请号：US11124619
申请日：2005-05-05
申请人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
发明人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
IPC分类号： A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D473/12 , A61K31/52
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation, preferably in a reversible manner. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集，优选以可逆的 方式。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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6.发明申请公开(公告)号：US20050159388A1
公开(公告)日：2005-07-21
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
发明人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
IPC分类号： A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D471/04 , C07D493/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formulae I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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公开(公告)号：US20080025372A1
公开(公告)日：2008-01-31
申请号：US11767362
申请日：2007-06-22
申请人： David Culbertson , Daniel Harvey , Robert Frake
发明人： David Culbertson , Daniel Harvey , Robert Frake
摘要： A temperature sensor assembly and method of manufacturing thereof having a temperature probe, a mounting connector, a wire set, a transition component, a housing, and a circuit is provided. The temperature probe includes a probe body, a temperature sensor and at least one conductor configured for providing a temperature signal indicative of a temperature over the at least one conductor. The circuit is enclosed within the housing and configured for receiving the temperature signal from the temperature probe and generating the temperature characteristic in response to the received temperature signal.
摘要翻译： 提供一种温度传感器组件及其制造方法，其具有温度探针，安装连接器，线组，过渡部件，壳体和电路。 温度探头包括探针体，温度传感器和配置用于提供指示至少一个导体上的温度的温度信号的至少一个导体。 电路被封装在壳体内并被配置成用于接收来自温度探测器的温度信号并响应于所接收的温度信号产生温度特性。
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8.发明申请公开(公告)号：US20080026610A1
公开(公告)日：2008-01-31
申请号：US11767373
申请日：2007-06-22
申请人： Robert Frake , David Culbertson , Daniel Harvey
发明人： Robert Frake , David Culbertson , Daniel Harvey
CPC分类号： B29C43/18 , B29C45/14426 , B29C45/14639 , H01R12/58 , H01R13/502 , H01R13/6658 , H01R13/6683 , H01R2201/20
摘要： A sensor adaptor circuit housing assembly and method of manufacturing includes a circuit board, a housing, an input wire, and a connector. The circuit board includes an electrical circuit configured for receiving a sensor signal and generating a sensor characteristic in response to the received sensor signal. The housing includes a body and a cavity defined by inner surfaces of the body and adapted for receiving the circuit board, the circuit board being positioned within the cavity. The input wire is configured for receiving the signal from a sensor and can be formed with an insulated solid or stranded conductor. The connector includes a unitary body, a first end of the unitary body attached directly to an end of the input wire, a second end of the unitary body positioned within the cavity and attached directly to the circuit board and making a first electrical connection with the electrical circuit.
摘要翻译： 传感器适配器电路壳体组件及其制造方法包括电路板，壳体，输入线和连接器。 电路板包括电路，该电路被配置为响应于所接收的传感器信号而接收传感器信号并产生传感器特性。 壳体包括主体和由主体的内表面限定并适于接收电路板的空腔，电路板位于空腔内。 输入线被配置为从传感器接收信号，并且可以形成绝缘的固体或绞合的导体。 连接器包括整体，整体的第一端直接附接到输入线的端部，整体的第二端位于空腔内，并直接连接到电路板上，并与第一电连接 电路。
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公开(公告)号：US20060020496A1
公开(公告)日：2006-01-26
申请号：US11150990
申请日：2005-06-13
申请人： Michael Azzarello , Daniel Harvey , Ben Barbosa
发明人： Michael Azzarello , Daniel Harvey , Ben Barbosa
IPC分类号： G06Q10/00
摘要： In an online system a passenger enters a trip, seeking an individual seat on a charter aircraft. Available charter operators and aircraft are selected from a database using scheduling and pricing algorithms to match the passenger's request to existing flights and newly created flights. The charter operator is alerted to the passenger request and requested to confirm their acceptance of the passenger's trip. The passenger receives a confirmation and a quote for the trip. The passenger is able to realize many of the benefits of charter travel at substantially lower prices.
摘要翻译： 在一个在线系统中，乘客进行旅行，在特许飞机上寻找个人座位。 从数据库中选择可用的特许运营商和飞机，使用调度和定价算法来匹配乘客对现有航班和新建航班的请求。 特许经营者被提醒乘客要求，并要求确认他们接受乘客的旅行。 乘客收到旅行的确认和报价。 乘客能够以较低的价格实现特许旅行的许多好处。
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