公开(公告)号：US10662439B2

公开(公告)日：2020-05-26

申请号：US14945140

申请日：2015-11-18

Applicant: Monsanto Technology LLC

Inventor： Gregory J. Bean ,  David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jason S. Milligan ,  Yong Yin

IPC: C12N15/82 ,  C07K14/195 ,  A01N63/20

Abstract: Insecticidal proteins exhibiting toxic activity against Coleopteran and Lepidopteran pest species are disclosed, and include, but are not limited to, TIC3668, TIC3669, TIC3670, TIC4076, TIC4078, TIC4260, TIC4346, TIC4826, TIC4861, TIC4862, TIC4863, and TIC-3668-type proteins. DNA molecules and constructs are provided which contain a polynucleotide sequence encoding one or more of the disclosed TIC3668-type proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran and Coleopteran infestation are provided which contain polynucleotide sequences encoding the insecticidal proteins of the present invention. Methods for detecting the presence of the polynucleotides or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using any of the TIC3668-type insecticidal proteins are also provided.

公开(公告)号：US20190055577A1

公开(公告)日：2019-02-21

申请号：US16179385

申请日：2018-11-02

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Todd A. Ciche ,  Uma R. Kesanapalli ,  Jennifer L. Lutke

IPC: C12N15/82 ,  C07K14/32 ,  A01N37/46 ,  A01N63/02 ,  C12Q1/6895 ,  G01N33/53

Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL pesticidal proteins are also provided.

公开(公告)号：US20180002386A1

公开(公告)日：2018-01-04

申请号：US15627164

申请日：2017-06-19

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jennifer L. Lutke

IPC: C07K14/32 ,  C12N15/82 ,  A01N63/02

CPC classification number: C12N15/8286 ,  A01N37/46 ,  A01N63/02 ,  C07K14/32 ,  Y02A40/162

Abstract: Nucleotide sequences are disclosed encoding novel, insecticidal TIC4747 and related proteins exhibiting Hemipteran and Lepidopteran inhibitory activity, as well as fragments thereof. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing a polynucleotide construct encoding one or more of the toxin proteins within the TIC4747-related protein toxin class.

公开(公告)号：US20170226163A1

公开(公告)日：2017-08-10

申请号：US15486804

申请日：2017-04-13

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine Chay ,  Artem Evdokimov ,  Stanislaw Flasinski ,  Uma R. Kesanapalli ,  Megan N. Schroder ,  Rachael N. Slightom ,  Nengbing Tao ,  Andrew M. Wollacott

IPC: C07K14/32 ,  C12N15/82 ,  A01N63/02

CPC classification number: C07K14/32 ,  A01N63/02 ,  C07K14/001 ,  C12N15/8286 ,  Y02A40/162

Abstract: The present invention discloses a genus of insect inhibitory proteins that exhibit properties directed to controlling Lepidopteran and/or Hemipteran crop pests, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

公开(公告)号：US20160068858A1

公开(公告)日：2016-03-10

申请号：US14945069

申请日：2015-11-18

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine Chay ,  Artem Evdokimov ,  Megan N. Schroder ,  Rachael N. Slightom ,  Uma R. Kesanapalli ,  Nengbing Tao ,  Andrew M. Wollacott

IPC: C12N15/82 ,  C07K14/32

CPC classification number: C12N15/8286 ,  C07K14/001 ,  C07K14/32 ,  Y02A40/162

Abstract: The present invention discloses a genus of insect inhibitory proteins that exhibit properties directed to controlling Lepidopteran and/or Hemipteran crop pests, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

公开(公告)号：US20250066808A1

公开(公告)日：2025-02-27

申请号：US18885363

申请日：2024-09-13

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jennifer L. Lutke ,  Eric Van Fleet

IPC: C12N15/82 ,  A01N37/46 ,  A01N63/23 ,  C07K14/32

Abstract: Nucleotide sequences are disclosed encoding novel, insecticidal TIC4747 and related proteins exhibiting Hemipteran and Lepidopteran inhibitory activity, as well as fragments thereof. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing a polynucleotide construct encoding one or more of the toxin proteins within the TIC4747-related protein toxin class.

公开(公告)号：US12234471B2

公开(公告)日：2025-02-25

申请号：US18506855

申请日：2023-11-10

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Todd A. Ciche ,  Uma R. Kesanapalli ,  Jennifer L. Lutke

IPC: C12N15/82 ,  A01N63/50 ,  C12Q1/6895

Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL pesticidal proteins are also provided.

公开(公告)号：US20250002931A1

公开(公告)日：2025-01-02

申请号：US18793450

申请日：2024-08-02

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Kimberley M. Wegener

IPC: C12N15/82 ,  A01N63/23 ,  A01N63/50 ,  A01P7/04 ,  C07K14/32

Abstract: Pesticidal protein exhibiting toxic activity against Lepidopteran and Hemipteran pest species are disclosed, and include, but are not limited to, TIC2199. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the disclosed pesticidal protein. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran and Hemipteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the protein of the present invention in a biological sample, and methods of controlling Lepidopteran and Hemipteran species pests using TIC2199 pesticidal protein are also provided.

公开(公告)号：US20240301441A1

公开(公告)日：2024-09-12

申请号：US18635866

申请日：2024-04-15

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Todd A. Ciche ,  Stanislaw Flasinski ,  Arlene R. Howe

IPC: C12N15/82 ,  A01N63/50 ,  C07K14/24 ,  C07K14/325

CPC classification number: C12N15/8286 ,  A01N63/50 ,  C07K14/24 ,  C07K14/325

Abstract: A pesticidal protein class of PirA, PirB, and PirAB fusion proteins exhibiting toxic activity against Coleopteran, Lepidopteran, and Hemipteran pest species is disclosed. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the PirA, PirB, and PirAB fusion proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran, Lepidopteran, and Hemipteran infestation are provided which contain recombinant nucleic acid sequences encoding the PirA, PirB, and PirAB fusion proteins. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, and Hemipteran species pests using the PirA, PirB, and PirAB fusion proteins are also provided.

公开(公告)号：US11807864B2

公开(公告)日：2023-11-07

申请号：US18151119

申请日：2023-01-06

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Todd A. Ciche ,  Uma R. Kesanapalli ,  Jennifer L Lutke

IPC: C12N15/82 ,  C12Q1/6895 ,  A01N37/46 ,  A01N63/50 ,  G01N33/53

CPC classification number: C12N15/8286 ,  A01N37/46 ,  A01N63/50 ,  C12Q1/6895 ,  C12Q2600/13 ,  G01N33/5308 ,  Y02A40/146 ,  A01N63/50 ,  A01N63/25

Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL pesticidal proteins are also provided.