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69 条记录 (耗时 0.049 秒)

    PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS
    63.
    发明申请
    PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS 审中-公开
    吡咯烷-2,3-二吡啶作为抗炎剂

    公开(公告)号：US20090131430A1

    公开(公告)日：2009-05-21

    申请号：US11720047

    申请日：2005-11-23

    申请人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

    发明人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

    IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61P29/00 ,  A61K31/519

    CPC分类号： C07D471/04

    摘要： The present invention relates to novel azabicyclo derivatives as anti-inflammatory agents. The compounds provided herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis. Also provided herein are pharmacological compositions containing compounds provided herein and associated methods of treating sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, and other inflammatory and/or autoimmune disorders, using the compounds.

    摘要翻译： 本发明涉及新型的氮杂二环衍生物作为抗炎剂。 本文提供的化合物可用于抑制和预防炎症和相关病理，包括炎性和自身免疫性疾病，例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣。 本文还提供含有本文提供的化合物的药物组合物和治疗败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣以及其它炎性和/或自身免疫性疾病的相关方法 ，使用该化合物。

    Substituted piperazine compounds
    66.
    发明授权
    Substituted piperazine compounds 失效
    取代的哌嗪化合物

    公开(公告)号：US06677336B2

    公开(公告)日：2004-01-13

    申请号：US09791134

    申请日：2001-02-22

    申请人： Jeff Zablocki ,  Elfatih Elzein ,  Grigory Nudelman ,  Tim Marquart ,  Brent K. Blackburn ,  Venkata P. Palle

    发明人： Jeff Zablocki ,  Elfatih Elzein ,  Grigory Nudelman ,  Tim Marquart ,  Brent K. Blackburn ,  Venkata P. Palle

    IPC分类号： A61K31495

    CPC分类号： C07D241/04 ,  C07D241/08 ,  C07D241/42 ,  C07D295/15 ,  C07D317/54 ,  C07D317/58

    摘要： Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

    摘要翻译： 新的通式化合物及其药学上可接受的酸加成盐，其中所述化合物可用于治疗以保护骨骼肌免受创伤损伤或保护肌肉或全身性疾病如间歇性跛行后的骨骼肌，以治疗休克 条件，以维持移植物中使用的供体组织和器官，治疗包括心房和室性心律失常的心血管疾病，Prinzmetal（变体）心绞痛，稳定性心绞痛和运动诱发的心绞痛，充血性心脏病和心肌梗塞。

    Aralkyl substituted piperazine compounds
    69.
    发明授权
    Aralkyl substituted piperazine compounds 失效
    芳烷基取代的哌嗪化合物

    公开(公告)号：US06552023B2

    公开(公告)日：2003-04-22

    申请号：US09791133

    申请日：2001-02-22

    申请人： Jeff Zablocki ,  Elfatih Elzein ,  Brent K. Blackburn ,  Tim Marquart ,  Prabha N. Ibrahim ,  Venkata P. Palle

    发明人： Jeff Zablocki ,  Elfatih Elzein ,  Brent K. Blackburn ,  Tim Marquart ,  Prabha N. Ibrahim ,  Venkata P. Palle

    IPC分类号： A61K31495

    CPC分类号： C07D295/15 ,  C07D241/04 ,  C07D241/08 ,  C07D241/42 ,  C07D317/54 ,  C07D317/58

    摘要： Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

    摘要翻译： 新的通式化合物及其药学上可接受的酸加成盐，其中所述化合物可用于治疗以保护骨骼肌免受创伤损伤或保护肌肉或全身性疾病如间歇性跛行后的骨骼肌，以治疗休克 条件，以维持移植中使用的供体组织和器官，治疗包括心房和室性心律失常的心血管疾病，Prinzmetal（变体）心绞痛，稳定性心绞痛和运动诱发的心绞痛，充血性心脏病和心肌梗死。